2016
DOI: 10.1016/j.ijpharm.2016.09.001
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Co-encapsulation of paclitaxel and baicalein in nanoemulsions to overcome multidrug resistance via oxidative stress augmentation and P-glycoprotein inhibition

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Cited by 85 publications
(44 citation statements)
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“…The GSH/GSSG ratio is widely used as an important indicator to evaluate the cellular redox system . As shown in Figure A, the GSH/GSSG ratios were significantly reduced in both BZML‐treated A549 and A549/Taxol cells.…”
Section: Resultsmentioning
confidence: 98%
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“…The GSH/GSSG ratio is widely used as an important indicator to evaluate the cellular redox system . As shown in Figure A, the GSH/GSSG ratios were significantly reduced in both BZML‐treated A549 and A549/Taxol cells.…”
Section: Resultsmentioning
confidence: 98%
“…However, ROS had no influence on the proportion of multi‐nucleated cells in BZML‐treated A549/Taxol cells. Meanwhile, GSH acts as a free radical scavenger and plays a protective role against ROS‐mediated anti‐cancer effects . Importantly, the overexpression of GSH has been associated with chemo‐ and radio‐resistance in cancer cells .…”
Section: Discussionmentioning
confidence: 99%
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“…15 Intracellular trafficking 16 MCF-7/ADR cells were seeded in confocal dishes with 5×10 5 cells/well density and cultured at 37°C for 24 h. The culture was then replaced by 400 μL of DOX-VRP-PENPs (diluted by RPMI 1640 cell culture medium without serum) and incubated for 4 h. The cells were washed thrice with icecold PBS, and Hoechst 33342 was used to dye the nucleus for 30 min. After, cells were washed thrice by PBS, and 0.5 mL paraformaldehyde (3.7% w/v) was added for 15 min to fix the cells.…”
mentioning
confidence: 99%