Co-encapsulation of quercetin and resveratrol in zein/carboxymethyl cellulose nanoparticles: characterization, stability and <i>in vitro</i> digestion

Yang, Zhongyu; McClements, David Julian; Peng, Xinwen; Qiu, Chao; Long, Jie; Zhao, Jianwei; Xu, Zhenlin; Meng, Man; Chen, Long; Jin, Zhengyu

doi:10.1039/d2fo02718f

Cited by 13 publications

(1 citation statement)

References 52 publications

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“…This may be due to the presence of hydroxyl groups on Cur [38], allowing polyphenols to form hydrogen bonds with proteins, which is consistent with previous research results [11]. Proteins and polyphenols form covalent bonds (hydrogen bonds and hydrophobic interactions) [39]. When Dio and Cur were co-encapsulated into zein-SPI NPs, it could be seen that the intensity of their amide II bond peaks became lower, which also indicated that Cur was more hydrophobic than Dio, and the co-loading drug caused Cur to enter into a more hydrophobic microenvironment.…”

Section: Ftirsupporting

confidence: 90%

Co-Encapsulation of Curcumin and Diosmetin in Nanoparticles Formed by Plant-Food-Protein Interaction Using a pH-Driven Method

Shan

et al. 2023

Foods

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In this work, a pH-driven method was used to prepare zein–soy protein isolate (SPI) composite nanoparticles (NPs). The mass ratio of SPI to zein influenced the Z-average size (Z-ave). Once the zeta potential stabilized, SPI was completely coated on the periphery of the zein NPs. The optimal mass ratio of zein:SPI was found to be 2:3. After determining the structure using TEM, curcumin (Cur) and/or diosmetin (Dio) were loaded into zein–SPI NPs for co-encapsulation or individual delivery. The co-encapsulation of Cur and Dio altered their protein conformations, and both Cur and Dio transformed from a crystalline structure to an amorphous form. The protein conformation change increased the number of binding sites between Dio and zein NPs. As a result, the encapsulation efficiency (EE%) of Dio improved from 43.07% to 73.41%, and thereby increased the loading efficiency (LE%) of zein-SPI NPs to 16.54%. Compared to Dio-loaded zein–SPI NPs, Cur/Dio-loaded zein–SPI NPs improved the storage stability of Dio from 61.96% to 82.41% within four weeks. The extended release of bioactive substances in the intestine during simulated gastrointestinal digestion improved the bioavailability. When exposed to a concentration of 0–800 µg/mL blank-loaded zein–SPI NPs, the viability of HepG2 and LO-2 cells was more than 90%, as shown in MTT assay tests. The zein–SPI NPs are non-toxic, biocompatible, and have potential applications in the food industry.

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Section: Ftirsupporting

confidence: 90%

Co-Encapsulation of Curcumin and Diosmetin in Nanoparticles Formed by Plant-Food-Protein Interaction Using a pH-Driven Method

Shan

et al. 2023

Foods

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R-Q@P-D nanoparticle for improving the oral bioavailability and therapeutic efficacy: A novel reversible dual-target-mild-inhibition intestinal metabolic enzymes strategy for resveratrol delivery

Cui,

Li,

Zhou

et al. 2024

Chemical Engineering Journal

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Pterostilbene binding to whey protein: Multi-spectroscopy and the antioxidant activity

Liang,

Chen,

Zhang

et al. 2024

Food Hydrocolloids

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Co-encapsulation of quercetin and resveratrol in zein/carboxymethyl cellulose nanoparticles: characterization, stability and in vitro digestion

Abstract: Oral administration of combinations of specific nutrients and nutraceuticals can provide synergistic health benefits to humans. In this work, zein/carboxymethyl cellulose composite nanoparticles were successfully prepared using antisolvent precipitation methods....

Cited by 13 publications

References 52 publications

Co-Encapsulation of Curcumin and Diosmetin in Nanoparticles Formed by Plant-Food-Protein Interaction Using a pH-Driven Method

Co-Encapsulation of Curcumin and Diosmetin in Nanoparticles Formed by Plant-Food-Protein Interaction Using a pH-Driven Method

R-Q@P-D nanoparticle for improving the oral bioavailability and therapeutic efficacy: A novel reversible dual-target-mild-inhibition intestinal metabolic enzymes strategy for resveratrol delivery

Pterostilbene binding to whey protein: Multi-spectroscopy and the antioxidant activity

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