Co‐Enzyme Q₁₀: A New Drug for Cardiovascular Disease

Abstract

Co-enzyme Q10 (ubiquinone) is a naturally occurring substance which has properties potentially beneficial for preventing cellular damage during myocardial ischemia and reperfusion. It plays a role in oxidative phosphorylation and has membrane stabilizing activity. The substance has been used in oral form to treat various cardiovascular disorders including angina pectoris, hypertension, and congestive heart failure. Its clinical importance is now being established in clinical trails worldwide.

Total Coenzyme Q10 Concentrations in Asian Men Following Multiple Oral 50-mg Doses Administered as Coenzyme Q10 Sustained Release Tablets or Regular Tablets.

“…After the initial dose for both formulations, the C max (1.20 mg/l vs. 1.15 mg/l) and T max (6 h vs. 6 h) were very similar. This suggests that the sustained release did not significantly delay the absorption rate, and indicated that dissolution is probably the more important factor rather than release and the absorption rate like that reported 4) seemed slow. Mean concentrations of CoQ 10 following multiple oral administration sustained release tablets are higher but not significantly, than that after regular tablets.…”

“…Total body content of CoQ 10 has been estimated to be 0.5-1.5 g. 4,10) The intracellular distribution of CoQ 10 is described as follows: nucleus 25-30%; mitochondria 40-50% (inner mitochondria membrane); microsomal 15-20%; cytosolic 5-10%. Following ingestion of 100 mg of CoQ 10 , 4) peak plasma levels occur between 5 and 10 h, indicating a slow absorption from the gastrointestinal tract due to its high molecular weight and low water solubility. After the initial dose for both formulations, the C max (1.20 mg/l vs. 1.15 mg/l) and T max (6 h vs. 6 h) were very similar.…”

“…Coenzyme Q 10 is an endogenous substance and oral CoQ 10 appears to have a low clearance rate from plasma. It has a relatively long plasma half-life of 33.9Ϯ5.32 h, and exogenously administrated CoQ 10 doses not appear to alter endogenous levels 4) but reported to be effective in the abovementioned diseases. The major portion of an exogenous dose of CoQ 10 is deposited in the liver and packaged into VLDL (Very low-density lipoprotein).…”

“…The major portion of an exogenous dose of CoQ 10 is deposited in the liver and packaged into VLDL (Very low-density lipoprotein). 4) The observation of total CoQ 10 level over a longer time period may provide a better profile of concentration after oral administration. Our purpose is to compare the total coenzyme Q 10 levels in Asian men following multiple oral 50 mg doses administered as sustained release tablets or regular tablets.…”

Relative Bioavailability of Coenzyme Q10 in Emulsion and Liposome Formulations

“…1) (Greenberg and Frishman, 1990;Tran et al, 2001). CoQ10 is found anywhere in the body, and is found in high concentration in tissues with high energy turnover such as heart, brain, liver, and kidney (Leonhauser et al, 1962;Sun et al, 1992;Bonakdar and Guarneri, 2005).…”