Co-existence of lepromatous leprosy and subcutaneous sarcoidosis: A rare paradoxical association?

Patil, Deena; Sharda, Tanya; Krishnappa, Rashmi; Sumathy, T K

doi:10.47276/lr.93.4.413

LEPROSY

2022

DOI: 10.47276/lr.93.4.413

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Co-existence of lepromatous leprosy and subcutaneous sarcoidosis: A rare paradoxical association?

Deena Patil

Tanya Sharda

Rashmi Krishnappa

et al.

Abstract: Lepromatous leprosy and sarcoidosis have varied clinical manifestations. These two diseases are sometimes mistaken for each other in their clinical, histopathological and laboratory parameters, but their coexistence is seemingly quite rare and paradoxical. We present a 40-year-old female with newly diagnosed lepromatous leprosy and subcutaneous sarcoidosis.

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Cited by 2 publications

References 7 publications

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An Unusual Presentation of Sarcoidosis: The Great Mimicker

Kumar,

Garg,

Taneja

et al. 2023

Journal of Advanced Lung Health

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Sarcoidosis is a very well-known disease for its variable clinical and radiological presentation. Thoracic involvement is the commonest manifestation of sarcoidosis followed by skin. We present here an interesting case report of an old-age patient with an unusual presentation of sarcoidosis. He was previously treated for leprosy based on skin biopsy with partial relief only. The unusual things in this patient were clinical and radiological findings. Clinically, he had only complaints of weight loss which had not been reported earlier; second, the skin lesions were not typical. The unusual radiological things were a disproportionate distribution of radiological lesions and predominant consolidation. Lower lobe consolidation in sarcoidosis is rarely reported, which was present in this patient. The perilymphatic micronodules were more concentrated on the right upper lobe as compared to the left upper lobes. Based on this case report we cannot deny the wrong diagnosis of leprosy because both diseases share common clinical and histopathological features.

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An Unusual Presentation of Sarcoidosis: The Great Mimicker

Kumar,

Garg,

Taneja

et al. 2023

Journal of Advanced Lung Health

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Darier-Roussy Subcutaneous Sarcoidosis: A Case-Based Review

Alnaimat,

AbuHelal,

Alshamaileh

2024

AAEE

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Sarcoidosis is a systemic granulomatous inflammatory condition characterized by varied clinical manifestations, with a higher prevalence observed in individuals aged 25 to 40 and women over 50. Typical presentations involve symmetric involvement of hilar and mediastinal lymph nodes, followed by lung involvement. While initial stages are often asymptomatic, the disease can impact various organs. Cutaneous involvement, observed in up to a quarter of patients, includes lupus pernio, papules, plaques, erythema nodosum, and occasionally subcutaneous nodules. Subcutaneous sarcoidosis, once considered rare, is now increasingly recognized. We present a case of Darier-Roussy sarcoidosis in a middle-aged man, demonstrating multiple painless subcutaneous nodules confirmed through biopsy. Our findings suggest that Darier-Roussy sarcoidosis typically manifests early in the disease course, indicating non-severe systemic involvement. Additionally, our patient responded well to hydroxychloroquine treatment, suggesting a positive outcome.

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Co-existence of lepromatous leprosy and subcutaneous sarcoidosis: A rare paradoxical association?

Cited by 2 publications

References 7 publications

An Unusual Presentation of Sarcoidosis: The Great Mimicker

An Unusual Presentation of Sarcoidosis: The Great Mimicker

Darier-Roussy Subcutaneous Sarcoidosis: A Case-Based Review

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