Co-existence of peptide HI (PHI) and VIP in nerves regulating blood flow and bronchial smooth muscle tone in various mammals including man

Lundberg, Jan M.; Fahrenkrug, Jan; Hökfelt, Tomas; Martling, Claes‐Roland; Larsson, Olof; Tatemoto, Kazuhiko; Änggård, Anders

doi:10.1016/0196-9781(84)90090-1

Cited by 252 publications

(67 citation statements)

References 26 publications

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“…Recently, PHM, the human counterpart of PHI has been revealed to be a part of the molecule of human preprovasoactive intestinal polypeptide (VIP) by sequence analysis of the mRNA. This has been confirmed by immunocytochemical studies, demonstrating in different mammals that immunoreactive VIP and PHI were contained in the same neurons (YANAIHARA et al, 1983;LUNDBERG et al, 1984).…”

Section: Discussionsupporting

confidence: 60%

“…VIP is a 28 amino acid neuropeptide widely distributed in the nervous system in vertebrates (SAID and RoSENBERG, 1976;LARSSON et al, 1976), but its occurrence in invertebrates has been demonstrated in restricted animals. In the deuterostomian protochordate, Ciona intestinalis, it has been shown that some VIP-immunoreactive neurons occur in the cerebral ganglion (FRITScH et al, 1982).…”

Section: Discussionmentioning

confidence: 99%

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PHI-like immunoreactivity in the nervous system of the cockroach (insect) and Aplysia (Mollusc) with special reference to its relationship to VIP-like immunoreactivity.

Kuramoto

Yui

Iwanaga

et al. 1985

Arch. Histol. Jap., Arch. Histol. Jpn

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

PHI-like immunoreactivity in the nervous system of the cockroach (insect) and Aplysia (Mollusc) with special reference to its relationship to VIP-like immunoreactivity.

Kuramoto

Yui

Iwanaga

et al. 1985

Arch. Histol. Jap., Arch. Histol. Jpn

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“…[25] PHI içeren sinirlerin serömüköz bezler, trake ve ana bronşlardaki düz kaslar ile yakından ilişkisinden bahsederken, [31] solunum yollarında PHI pozitif materyalin bulunmasının izole edilen kobay trake düz kasları üzerinde gevşetici etkisi göstermesinin ve klasik nörotransmitter bloke edici ajanlardan etkilenmemesinin ilginç olduğunu bildirmektedirler. Bu konuda yapılan çalışmalarda [13], yetişkin rat, kobay, kedi ve domuzlarda [14], kobay, rat ve kedide [32] insan, yetişkin fare, rat, kobay ve kedide VIP ve PHI-pozitif fibrillerin solunum kanalında trake düz kas tabakası içinde ve çevresinde görüldüğünü bildirmişlerdir. Bu çalışmada da benzer bulgu elde edildi.…”

Section: Peptide Histidine Isoleucine (Phi)unclassified

“…PHI, VIP'e göre pulmonar genişletici olarak ciddi ölçüde daha az etkindir ve VIP gibi endotel hücrelerinden bağımsız olarak etkilerini göstermektedir [16]. VIP [17] ve PHI [18] solunum yollarındaki parasempatik perivasküler sinirlerde birlikte bulunmaktadırlar [13].…”

Section: Introductionunclassified

Koyun (Ovis aries) Trakea Mukozasındaki Bazı Peptidlerin İmmunohistokimyasal Lokalizasyonları

Nada¹,

Çınar²

2017

SDÜ Fen Bil Enst Der

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Özet: Bu çalışmada, koyun (Ovis aries), (alt ve üst) trake mukozasında GAL (Galanin), PHI (Peptit Histidin İzolösin) ve Leu-Enk (Leu-Enkefalin) peptitlerinin immunohistokimyasal lokalizasyonlarının belirlenmesi amaçlandı. Üst trake lamina epitelyalisindeki GAL, PHI ve Leu-ENK immunoreaktif hücrelerin yoğunluğunun alt trakeye göre daha fazla olduğu saptandı. PHI immunoreaktif hücrelerin ise üst trake lamina epitelyalisinde diğer peptitlere göre daha fazla sayıda bulunduğu belirlendi. GAL, PHI ve Leu-ENK immunoreaktivitesine aynı zamanda düz kas, serömuköz bez hücreleri, bu bezler ile kan damarları çevresinde ve gangliyon hücrelerinde de rastlandı. Sonuç olarak GAL, Leu-ENK ve PHI'nın geniş mukozal dağılımının, memeli solunum sistemindeki vasküler ve sekretuvar fonksiyonların düzenlemesinde etkili olabileceği düşünülmektedir. Solunum yolu epitellerinde bulunan GAL, PHI ve ENK peptidleri, düzenleyici peptid hormonların ya da nörotransmitterlerin lokal olarak harekete geçirilmesinde de etkili olabilirler. The Immunohistochemical Localization of Some Peptides in Sheep (Ovis aries) Tracheal MucosaKeywords Rachea, Mucosa, Immunohistochemistry, Galanin, Peptide Histidin Isoleucine, Leu-Enkephalin, Abstract:This study aimed to determine immunohistochemical localization of the peptides Galanin (GAL), Peptide Histidin Isoleucine (PHI) and Leu-Enkephalin (Leu-ENK) in tracheal mucosa (upper and lower) of sheep (Ovis aries). It was observed that GAL, PHI and Leu-ENK immunoreactive cells were more numerous in the upper part of trachea than in its lower part. It was found that PHI-immunoreactive cells were more than other peptides in lamina epithelialis in upper trachea. GAL, PHI and Leu-ENK immunoreactivity was detected in smooth muscles, seromucous gland cells, around blood vesels and in ganglion cells. In conclusion, it is thought that wideranging mucosal distribution of GAL, Leu-ENK and PHI may have effective in regulating the vascular and secretory functions in mammalian respiratory system. Existence of the peptides GAL, PHI and Leu-ENK in the airway epithelium suggests that they may also be effective in acting as regulatory peptides, local hormones or neurotransmitters.

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“…Immunohistochemical studies have localized immunoreactive VIP in nerve fibres within airway smooth muscle, surrounding tracheobronchial mucous and serous glands, in the walls of airway blood vessels and in microganglia within the lungs (Dey et al, 1981;Laitinen et al, 1985;Lundberg et al, 1984;Polak et al, 1986;Said, 1988). Moreover, specific, high affinity receptors for VIP have been identified in membrane preparations of rat, mouse, guinea-pig and human lungs (Said, 1987) and on airway glands, epithelium and vascular smooth muscle of human and guineapig lung (Carstairs & Uddman & Sundler, 1987).…”

Section: Introductionmentioning

confidence: 99%

Effects of vasoactive intestinal polypeptide on antigen‐induced bronchoconstriction and thromboxane release in guinea‐pig lung

Ciabattoni

Montuschi

Currò

et al. 1993

British J Pharmacology

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1 Exogenous vasoactive intestinal polypeptide (VIP) infused into the pulmonary artery of isolated and ventilated lungs of guinea-pigs decreased, in a dose-dependent fashion (1.0-10.0 nmol), airway resistance and thromboxane B2 (TXB2, the stable hydrolysis product of TXA2) release in the perfusion medium. Prostacyclin (PGI2) synthesis, as reflected by the release of its stable hydrolysis product 6-oxo-PGFI,,, was unaffected. Pretreatment with the 5-lipoxygenase inhibitor BWA4c (3.5 x 10-' M) did not modify the bronchodilatory effect of VIP or its inhibitory action on TXB2 release. 2 Basal release of immunoreactive VIP from perfused lungs decreased from an initial value of 0.96 ± 0.10 ng min-' (mean ± s.e.mean) in the first 2 min to an average of 0.58 ± 0.10 ng min-' in the following 15-20 min. 3 Antigen challenge with ovalbumin (0.1%) in sensitized lungs caused an anaphylactic reaction in 45% of tested lungs, concomitant with a 5 fold increase in both VIP and TXB2 release. Tetrodotoxin pretreatment (10-6 M) reduced basal VIP release by >80% and abolished the VIP increase observed during anaphylaxis, without modifying TXB2 release or the bronchoconstrictor response. 4 Indomethacin (10-6 M) inhibited TXB2 synthesis and release by > 90%, delayed the bronchoconstrictor response and blunted the increased VIP release during lung anaphylaxis, without influencing basal VIP release. 5 The 5-lipoxygenase inhibitor BWA4c (3.5 x 10-5 M) blunted the increase of TXB2 and VIP release from guinea-pig lung and attenuated the bronchoconstrictor response following ovalbumin challenge. 6 The administration of exogenous VIP as a continuous infusion (10-8 M) attenuated the bronchoconstriction and the release of cyclo-oxygenase metabolites following antigen challenge.7 Acetylcholine (10-6-Il-5 M) infused into the pulmonary artery induced a dose-dependent bronchoconstriction not associated with enhanced VIP or TXB2 release.8 The TXA2 mimetic U-46619 (0.1-1.0 nmol) caused dose-dependent increases in airway resistance, concomitant with an up to 10 fold increase in VIP release. VIP inhibited arachidonate-induced in vitro aggregation of washed rabbit platelets in a dose-dependent manner over a dose range 10-8 10-6 M. Despite the antiaggregatory effect of VIP, TXB2 and PGE2 synthesis was reduced only to a minor extent, and there was no redirection of arachidonate metabolism from TXA2 to PGE2, indicating that VIP does not act as a TX synthase inhibitor in vitro. 9 We conclude that VIP may play a role in regulating bronchial smooth muscle reactivity in lung anaphylaxis by inhibiting the synthesis and release of TXA2, a potent vasoactive and bronchoconstrictor agent. TXA2, on the other hand, strongly enhances neuronal VIP release.

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Co-existence of peptide HI (PHI) and VIP in nerves regulating blood flow and bronchial smooth muscle tone in various mammals including man

Cited by 252 publications

References 26 publications

PHI-like immunoreactivity in the nervous system of the cockroach (insect) and Aplysia (Mollusc) with special reference to its relationship to VIP-like immunoreactivity.

PHI-like immunoreactivity in the nervous system of the cockroach (insect) and Aplysia (Mollusc) with special reference to its relationship to VIP-like immunoreactivity.

Koyun (Ovis aries) Trakea Mukozasındaki Bazı Peptidlerin İmmunohistokimyasal Lokalizasyonları

Effects of vasoactive intestinal polypeptide on antigen‐induced bronchoconstriction and thromboxane release in guinea‐pig lung

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