Co‐existence of Philadelphia chromosome positive acute megakaryoblastic and B‐lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia

Abstract

In this study, we describe an extremely rare case of co-existence of a Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia. A morphological, immunophenotypical and cytogenetic study has been performed to characterize the case and in order to identify the origin of two disorders. After the failure of the conventional therapy, the patient was treated with Imatinib with a complete hematological and cytogenetic response and a marked reduction of bone marrow fibrosis.

In vitro effects of imatinib on CD34+ cells of patients with chronic myeloid leukemia in the megakaryocytic crisis phase

“…Megakaryocytic blast crisis as the presenting manifestation of CML is rare. Previous studies (11,12,19), with the exception of a study by Westfall et al (20), have shown that imatinib has good effects on patients with a megakaryocytic blast crisis of CML. However, the in vitro effect of exposure to imatinib on the proliferation or apoptosis of CD34 + cells from patients with CML in the megakaryocytic crisis phase has not been described.…”

Identification of an Acute Basophilic Leukaemia Carrying a Rare e6a2 BCR-ABL Transcript

“…On clinical examination, there was no hepatosplenomegaly or cutaneous lesions or symptoms related to hyperhistaminaemia. Pe-revealed the following karyotype: 46,XY [2]/46,XY,t(9; 22)(q34;q11) [4]. FISH analysis with dual colour probes for BCR and ABL genes [LSI bcr/abl Dual Colour Translocation Probe (VYSIS)] confirmed BCR/ABL fusion associated with 5 ABL deletion.…”