Background: Little is known about the relationship of active travel to school (ATS) with physical activity (PA) and screen time (ST) by individual and parental characteristics among adolescents, especially in China. To address the research gap, this study aimed to explore the difference of sex, age, geographical location, parental occupation and education level in the relationship of ATS with PA and ST among students of grades 7-12 using cross-sectional data.Methods: In 13 cities of Hubei province, China, students from 39 public schools were recruited to engage in the survey. In total, 5898 students (response rate = 89.6%) were invited into this study. Participants were required to report their ATS (including its types), PA and ST as well as sociodemographic information using validated questionnaire. Descriptive analyses were used to report the information of all variables. Regression models were used to analyze the relationships of ATS and its types with PA and ST.Results: In a total of 4128 participants (boy: 50.9%; younger adolescents: 61.9%) included in the final analysis, the proportion of those with ATS was 47.3%. Regarding the types of ATS, walking accounted for over 30%, while cycling was 13.2%. Participants with ATS were more likely to have sufficient PA (OR = 1.26, 95% CI: 1.14-1.39), especially among boys, younger adolescents and those with lower parental education level. However, ATS was not associated with ST (OR = 0.94, 95% CI: 0.86-1.01). Participants with cycling had higher odds ratio of being physically active (OR for cycling = 1.47, 95% CI: 1.27-1.70; OR for walking = 1.18, 95% CI: 1.06-1.32). The association of ATS types with PA and ST differed by gender, age, geographical location and parental educational level as well as occupations.Conclusions: ATS may be a useful approach to increase PA among adolescents, but this should be explained by individual and parental characteristics.