Co-existence of typhoid fever and hepatitis A

Zaki, Syed Ahmed; Shanbag, Preeti

doi:10.4103/1755-6783.105163

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…2,3 There are also case reports of coexistence of enteric fever with Viral hepatitis A, but have ALT: LDH ratio more than 9, but in our case ALT: LDH ratio <9 and IgM HAV negative. 8,9 Salmonella pancreatitis is also a rarely reported complication with incidence not clearly reported in literature. Our patient had amylase lipase >3times ULN with abdominal pain suggestive of pancreatitis and CT scan abdomen showing acute interstitial pancreatitis.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2015

MOJCR

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Enteric fever is predominantly a tropical disease caused by Salmonella typhi and paratyphi. Enteric fever commonly presents with altered liver function tests, but Salmonella is a rare cause for acute hepatitis presentation. Also Salmonella lead to acute pancreatitis with rhabdomyolysis leading to renal failure. We report an otherwise immunocompetent adult male who presented with acute hepatitis with coagulopathy, acute pancreatitis along with rhabdomyolysis, renal failure and delirium which finally turned out to be a case of Salmonella typhi causing enteric fever.

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Section: Discussionmentioning

confidence: 99%

Untitled

2015

MOJCR

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“…Poor sanitation and contaminated food and water aid the feco-oral spread of these diseases given that humans are the only reservoir for both. In few cases, enteric fever and hepatitis A coexist and cause diagnostic ambiguity, thereby leading to delayed diagnosis and treatment 1. This case report is about a 35-year-old man, who had concurrent infection with Salmonella typhi and hepatitis A.…”

Section: Introductionmentioning

confidence: 97%

Coinfection of enteric fever and hepatitis A

Oomen

Pillai

2022

BMJ Case Rep

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Poor sanitation and contaminated food and water are major risk factors for several infectious diseases like enteric fever and hepatitis A, but their coinfection is uncommon. Although the liver is frequently affected in typhoid fever, substantial hepatic dysfunction in an appropriately treated patient is uncommon. Our patient had high-grade fever with mild transaminitis and blood culture that grew Salmonella typhi. Despite being treated with culture-sensitive antibiotic at adequate dosage, he developed jaundice and had worsening transaminitis (>1000 IU/L) which was suggestive of hepatotropic virus infection. Hepatitis A IgM was positive. He was treated appropriately with which clinical and laboratory parameters resolved.

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“…There have been case reports on HAV and S. Typhi coinfection in children from other Indian settings, but not with S. Poona. 9,10 The child coinfected with S. Typhi and HAV presented with inflammatory changes in the gall bladder, and it is unclear whether inflammation of the gallbladder in HAV infection favors the persistence of S. Typhi, predisposing them to the carrier state. [11][12][13] This is the first report from India reporting a coinfection of HAV and S. Poona in a child.…”

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confidence: 99%

Hepatitis A Outbreak with the Concurrence of Salmonella Typhi and Salmonella Poona Infection in Children of Urban Vellore, South India

Srinivasan

Sindhu

Kumar

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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We investigated an outbreak of hepatitis A infection among children in an urban settlement of Vellore, South India. A total of 58 cases of jaundice were reported between April and August 2019. Sera from children who presented with jaundice were tested for hepatitis A virus (HAV) IgM. HAV IgM was positive in 18 (94.7%) of the 19 cases tested. These children also received a blood culture at the same time, as a part of the ongoing Surveillance for Enteric Fever in India (SEFI). Blood cultures from three children with confirmed hepatitis A infection grew Salmonella sp.: two with Salmonella Typhi and one with Salmonella Poona. Salmonella Poona is being reported for the first time from India. The overall hospitalization rate during the outbreak was 21%. Outbreaks of hepatitis A continue to occur with substantial morbidity in children from endemic settings, with notable emergence of other concurrent enteric infections, thereby warranting continued surveillance.

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Co-existence of typhoid fever and hepatitis A

Cited by 5 publications

References 5 publications

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Coinfection of enteric fever and hepatitis A

Hepatitis A Outbreak with the Concurrence of Salmonella Typhi and Salmonella Poona Infection in Children of Urban Vellore, South India

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