Co-existing autosomal dominant polycystic kidney disease and nephrotic syndrome in a Nigerian patient with lupus nephritis

Akinbodewa, Akinwumi Ayodeji; Adejumo, Oluseyi Ademola; Ogunsemoyin, A; Osasan, Stephen; Adefolalu, O A

doi:10.4103/1596-3519.179735

Cited by 2 publications

(1 citation statement)

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“…This has hampered knowledge about the disease in our setting as demonstrated by the few studies and case reports that have been published on ADPKD in Nigeria to date. [7][8][9] We therefore set out to determine the pattern of clinical presentation and outcome of ADPKD among patients who presented to our renal unit.…”

Section: Introductionmentioning

confidence: 99%

Clinical presentation and outcome of autosomal dominant polycystic kidney disease in Nigeria

Arogundade¹,

Akinbodewa²,

Sanusi³

et al. 2018

Afr H. Sci.

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Abstract:Introduction: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is presumably rare in Africa. Knowledge about the disease in Nigeria is limited as demonstrated by scanty articles on the subject. Objectives: To determine the pattern of clinical presentation and outcome of ADPKD among ADPKD patients. Method: ADPKD subjects were prospectively studied between January 1996 and December 2010. Their demographics, clinical and investigation parameters were documented. Dependency on dialysis, renal transplant and death were the final outcomes. Results: Forty one patients (M:F=1.3:1) with mean age of 48.6±4.6 years were studied. ADPKD was diagnosed at 2.73 cases per annum. Family history of ADPKD and hypertension were present in 56.1% and 82.9% respectively. Their mean systolic and diastolic blood pressures were 166.9 ±23.6 and 104 ±21.2 respectively. Nocturia (78.0%) and loin pain (68.3%) were the most common presenting symptoms. Liver cysts (31.7%) and aortic regurgitation (22.0%) were the predominant extra-renal manifestations. Twenty three (56.1%) received haemodialysis; no renal transplantation. Death rate was 51.2%. Presence of uraemia and intra-cerebral aneurysm contributed significantly to mortality. Conclusion: ADPKD may not be so rare in Nigeria. Awareness campaign to change attitude of family members to screening and further studies using newer criteria for diagnosis of ADPKD should be conducted.

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Section: Introductionmentioning

confidence: 99%

Clinical presentation and outcome of autosomal dominant polycystic kidney disease in Nigeria

Arogundade¹,

Akinbodewa²,

Sanusi³

et al. 2018

Afr H. Sci.

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New treatment paradigms for ADPKD: moving towards precision medicine

Lanktree

Chapman

2017

Nat Rev Nephrol

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The natural history of autosomal dominant polycystic kidney disease (ADPKD) is characterized by a variable rate of cyst development and increase in total kidney volume (TKV), variable kidney function decline and age of onset of end-stage renal disease (ESRD), and variable presentation of renal and extrarenal manifestations. Precision medicine is proposed to improve patient outcomes by tailoring therapy to the specific genetic background, pathophysiology, disease burden, prognosis and status of each individual. This approach to the management of patients with ADPKD is nearing clinical implementation owing to advances in genetics, imaging, biomarker development and therapeutics. In this Review, we discuss pharmacological and non-pharmacological interventions for the treatment of hypertension and proteinuria, and for slowing the rate of cyst growth in patients with ADPKD before the development of ESRD. We provide recommendations for the management of renal complications, including cyst infection, nephrolithiasis, haematuria and chronic pain. The early treatment of patients with ADPKD who are largely asymptomatic is associated with a therapeutic burden but slows cyst growth and delays subsequent loss of kidney function, which ultimately delays the need for renal replacement therapy and has a positive effect on the quality of life of patients.

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Co-existing autosomal dominant polycystic kidney disease and nephrotic syndrome in a Nigerian patient with lupus nephritis

Cited by 2 publications

References 6 publications

Clinical presentation and outcome of autosomal dominant polycystic kidney disease in Nigeria

Clinical presentation and outcome of autosomal dominant polycystic kidney disease in Nigeria

New treatment paradigms for ADPKD: moving towards precision medicine

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