Co-existing sickle cell anaemia and inflammatory bowel disease: case report and review of the literature

Adepoju, Adedayo A.; Akere, Adegboyega; Ogun, G O; Ogunbosi, Babatunde O.; Asinobi, Adanze Onyenonachi; Bello, Oluwasomidoyin Olukemi; Orimadegun, Adebola E.; Allen, Stephen; Akinyinka, O. O.

doi:10.1080/20469047.2021.1936393

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…To date, only one concurrent case of sickle cell anemia and ulcerative colitis has been reported in sub-Saharan Africa. 3,4 The spleen is particularly vulnerable in sickle cell anemia, and evidence of hyposplenism, characterized by fibrosis and atrophy, can typically be observed within the first five years of life. In our patient, functional asplenia was present, leading to anatomical asplenia.…”

Section: Introductionmentioning

confidence: 99%

Sickle Cell Disease With Ulcerative Colitis in An Ethiopian Child

Tamire,

Million

2024

IMCRJ

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Sickle cell disease (SCD) is a hereditary blood disorder characterized by abnormal hemoglobin, resulting in various clinical manifestations. Recognizing the complex clinical picture of SCD is crucial for physicians to effectively diagnose and manage the disease. While typical presentations may be absent, it is important to consider the possibility of SCD in patients presenting with ulcerative colitis (UC). The concurrent occurrence of UC and SCD is extremely rare. Therefore, a comprehensive investigation is warranted for individuals at risk of developing SCD with UC. In this report, we presented the first documented case of a child in Ethiopia with both SCD and UC.

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Section: Introductionmentioning

confidence: 99%

Sickle Cell Disease With Ulcerative Colitis in An Ethiopian Child

Tamire,

Million

2024

IMCRJ

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“…8,9 Less common hepatobiliary and splenic complications reported include hepatic and splenic abscesses, 10 spontaneous biloma, and pneumobilia. 11 In addition to hepatosplenic complications, clinicians need to consider other GI system complications that are not unique to SCD including acute appendicitis, 12,13 inflammatory bowel disease, 14 Helicobacter pylori or NSAID-associated gastritis and/or GI bleed, 15 acute pancreatitis (AP), 16,17 endocrine system etiologies including new-onset diabetes with diabetic ketoacidosis, 18 and genitourinary system etiologies including renal abscess, 19 and bladder necrosis. 20 It is important for clinicians evaluating patients with abdominal pain to consider these other etiologies, as early diagnosis and treatment of other GI complications is critical to reducing morbidity.…”

Section: Introductionmentioning

confidence: 99%

Gastrointestinal symptoms, diagnostic evaluations, and abdominal pathology in children with sickle cell disease

Dike,

Fittro,

Oster

et al. 2023

Pediatric Blood & Cancer

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BackgroundChildren with sickle cell disease (SCD) frequently present with acute pain. The abdomen, a common site of acute SCD‐related pain, may be present in a variety of gastrointestinal (GI) pathologies. Limited data exist on prevalence and workup of abdominal pain in patients with SCD during acute pain events.ObjectivesDetermine prevalence of GI symptoms, GI‐specific evaluation and risks of hospitalization in children with SCD presenting to the emergency department (ED) or hospitalized with abdominal pain.MethodsRetrospective study of children less than 21 years presenting to the ED or hospitalized with pain in our center over 2 years. Descriptive statistics were used to report clinical characteristics, frequency of GI symptoms, workup by age (<5 vs. ≥5 years), and genotype (sickle cell anemia [SCA] vs. non‐SCA). Logistic regression models were used to identify risks associated with hospitalization.ResultsA total of 1279 encounters in 378 patients were analyzed; 23% (n = 291) encounters were associated with abdominal pain. More abdominal pain‐associated hospitalizations occurred in older children, SCA, children with lower mean hemoglobin (8.7 ± 1.9 vs. 9.6 ± 1.6 g/dL, p < .001) and higher mean white blood cell (WBC) count (14.9 ± 6.6 vs. 13.2 ± 5.3 × 103/μL, p = .02). We identified that less than 50% of patients presenting to the ED with abdominal pain received a GI‐specific evaluation.ConclusionChildren with SCD frequently present with abdominal pain and other GI symptoms, with limited GI evaluations performed. GI‐specific evaluation may increase diagnosis of GI pathologies, rule out GI pathologies, and contribute to the limited knowledge of the abdomen as a primary site of SCD pain.

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Ulcerative colitis in patients with sickle cell disease: a rare but important co-morbidity

Rankine-Mullings

2022

Paediatrics and International Child Health

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Co-existing sickle cell anaemia and inflammatory bowel disease: case report and review of the literature

Cited by 3 publications

References 33 publications

Sickle Cell Disease With Ulcerative Colitis in An Ethiopian Child

Sickle Cell Disease With Ulcerative Colitis in An Ethiopian Child

Gastrointestinal symptoms, diagnostic evaluations, and abdominal pathology in children with sickle cell disease

Ulcerative colitis in patients with sickle cell disease: a rare but important co-morbidity

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