Co-exposure to internal and external radiation alters cesium biokinetics and retention in mice

Bertho, Jean-Marc; Bo, Raphaël; Magneron, Victor; Legendre, Audrey; Cochard, M.; Broggio, David; Tack, Karine

doi:10.1088/1361-6498/ab7b43

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…137 Cs in particular is the most common fission product with a half-life of ~30 years, emitting γ radiation. Variable dose rates, generally below 1 Gy/day, depend on the amount of ingested radionuclides or groundshine [ 5 ] and have the potential to lead to variable effective doses and consequent biological effects, especially when external and internal exposures are combined [ 6 ], unless mitigated by administration of chelating drugs, such as Prussian blue [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Serum Metabolomic Alterations Associated with Cesium-137 Internal Emitter Delivered in Various Dose Rates

Lin

Laiakis

et al. 2020

Metabolites

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Our laboratory and others have use radiation metabolomics to assess responses in order to develop biomarkers reflecting exposure and level of injury. To expand the types of exposure and compare to previously published results, metabolomic analysis has been carried out using serum samples from mice exposed to 137Cs internal emitters. Animals were injected intraperitoneally with 137CsCl solutions of varying radioactivity, and the absorbed doses were calculated. To determine the dose rate effect, serum samples were collected at 2, 3, 5, 7, and 14 days after injection. Based on the time for each group receiving the cumulative dose of 4 Gy, the dose rate for each group was determined. The dose rates analyzed were 0.16 Gy/day (low), 0.69 Gy/day (medium), and 1.25 Gy/day (high). The results indicated that at a cumulative dose of 4 Gy, the low dose rate group had the least number of statistically significantly differential spectral features. Some identified metabolites showed common changes for different dose rates. For example, significantly altered levels of oleamide and sphingosine 1-phosphate were seen in all three groups. On the other hand, the intensity of three amino acids, Isoleucine, Phenylalanine and Arginine, significantly decreased only in the medium dose rate group. These findings have the potential to be used in assessing the exposure and the biological effects of internal emitters.

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Section: Introductionmentioning

confidence: 99%

Serum Metabolomic Alterations Associated with Cesium-137 Internal Emitter Delivered in Various Dose Rates

Lin

Laiakis

et al. 2020

Metabolites

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Bisphosphonate Liposomes for Cobalt and Strontium Decorporation?

Landon,

Phan,

Fay

et al. 2024

Health Physics

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During a nuclear/radiological incident or an accident involving internal intakes with radioactive cobalt or strontium, the recommended treatments, consisting of the administration of diethylenetriaminepentaacetic acid for 60Co and calcium gluconate for 90Sr, are of low specificity, and their effectiveness can be enhanced. In this manuscript, a liposomal formulation was developed to deliver potential chelating agents to the main retention organs of both radionuclides. A bisphosphonate, etidronate, has been selected as a possible candidate due to its satisfying decorporation activity for uranium, bone tropism, and potential affinity with cobalt. Pre-clinical studies have been carried out on rats using radionuclide contamination and treatment administration by the intravenous route. The effectiveness of free or liposomal etidronate was evaluated, with an administration at 30 min, 48 h post-contamination with 60Co. Regarding 85Sr, a more extended experiment with etidronate liposomes was performed over 6 d. The results were compared to those performed with reference treatments, diethylenetriaminepentaacetic acid for cobalt and calcium gluconate for strontium. Unexpected results were found for the reference treatments that were significantly less effective than previously reported or showed no effectiveness. Free etidronate revealed no significant efficacy after 48 h, but the liposomal form suggested an interaction with radionuclides, not sufficient to change the biokinetics. This study emphasizes the need for early treatment administration and further research to provide a more effective medical countermeasure.

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Sexual dimorphism in 137Cs accumulation after chronic low dose exposure in mice

Quelquejay,

Brizais,

Bachelot

et al. 2024

Preprint

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The presence of Cesium-137 (137Cs) in the environment after nuclear accidents at Chernobyl and Fukushima Daiichi raises many health issues for the surrounding populations chronically exposed through the food chain. Unlike previous in vivo studies that focused solely on male exposures, this experimental research aims to assess the biodistribution and dosimetry of low-dose 137Cs internal exposure in both male and female C57BL/6 mice. This study uses a previously established model for chronic ingestion of 137Cs, simulating various exposure scenarios. Male and female C57BL/6 mice were exposed to concentrations resembling those ingested daily by residents in contaminated areas (20 kBq/L), as well as 5- and 10-times higher concentrations, for either 6 or 24 weeks. Throughout this period, the animals were closely monitored to determine and quantify the 137Cs content and to calculate absorbed doses. After 6 or 24 weeks exposure to chronic 137Cs in drinking water at 500 kBq/L, 137Cs concentration varied according to the organs and the sex of the animals. Males showed a higher body burden of 137Cs compared to females, with significant differences observed as soon as day 11. As well, the organs showing the highest 137Cs concentrations were skeletal muscle in males and in females, with significant differences between males and females. Regarding excretion, it appears that the elimination of 137Cs through feces was similar in males and females. By contrast, female mice showed a higher rate of 137Cs urine excretion than males, thus explaining the lower body burden in females. The resulting absorbed doses, calculated using dose conversion factors provided by ICRP publication 108, showed that the absorbed dose is 1.85 times less in female mice compared to male mice. 36.1 mGy in females and 66.9 mGy in males after 6 weeks exposure. 182.0 mGy in females and 310.0 mGy in males after 24 weeks exposure. This study demonstrates for the first time, sexual dimorphism in 137Cs biokinetics between males and females. These findings could refine biokinetic models of cesium and absorbed dose estimations in case of internal contamination, especially in post-accidental situations.

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Co-exposure to internal and external radiation alters cesium biokinetics and retention in mice

Abstract: Exposures in post-accidental situations are complex and include both external exposure and internai 1 4 11 12 13 14 17 18 19 41 42 43 44 45 46 48

Cited by 3 publications

References 39 publications

Serum Metabolomic Alterations Associated with Cesium-137 Internal Emitter Delivered in Various Dose Rates

Serum Metabolomic Alterations Associated with Cesium-137 Internal Emitter Delivered in Various Dose Rates

Bisphosphonate Liposomes for Cobalt and Strontium Decorporation?

Sexual dimorphism in 137Cs accumulation after chronic low dose exposure in mice

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