2023
DOI: 10.3389/fpubh.2023.1265864
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Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in the striatum

Sarita Pyatha,
Haesoo Kim,
Daeun Lee
et al.

Abstract: Humans are exposed to lead (Pb), mercury (Hg), and cadmium (Cd) through various routes, including drinking water, and such exposure can lead to a range of toxicological effects. However, few studies have investigated the toxic effects of exposure to mixtures of metals, particularly in relation to neurotoxicity. In this study, 7-week-old male mice were exposed to Pb, Hg, and Cd individually or in combination through their drinking water for 28 days. The mice exposed to the metal mixture exhibited significantly … Show more

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Cited by 12 publications
(1 citation statement)
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“…Heavy metals cause neuronal damage as individual metals, but mixtures of heavy metals also are harmful. Simultaneous exposure to lead, mercury, and cadmium causes greater brain damage in mice with reduced motor coordination and impaired learning and memory abilities than exposure to individual metals [133].…”
Section: Neurological Symptomsmentioning
confidence: 99%
“…Heavy metals cause neuronal damage as individual metals, but mixtures of heavy metals also are harmful. Simultaneous exposure to lead, mercury, and cadmium causes greater brain damage in mice with reduced motor coordination and impaired learning and memory abilities than exposure to individual metals [133].…”
Section: Neurological Symptomsmentioning
confidence: 99%