Co-expression Analysis of Genes and Tumor-Infiltrating Immune Cells in Metastatic Uterine Carcinosarcoma

Huang, Runzhi; Sun, Hao; Yan, Gaili; Zhang, Lili; Sun, Weiwei; Zhang, Jie; Yin, Huabin; Hu, Peng; Yan, Penghui; Zhu, Xiaolong; Meng, Tong; Wang, Jun; Huang, Zongqiang

doi:10.1007/s43032-021-00584-5

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…17) leading to a AK8-DST fusion in a single European patient (ISUP GG1, 67 years). Although no associations have been made between PCa, higher expression of DST has been identi ed to promote pathogenesis and development of breast cancer, while AK8 downregulation has been found to promote migration and invasion of uterine carcinosarcoma 71 .…”

Section: Discussionmentioning

confidence: 99%

Rare pathogenic structural variants show potential to enhance prostate cancer germline testing for African men

Hayes,

Gong,

Jiang

et al. 2024

Preprint

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Prostate cancer (PCa) is highly heritable, with men of African ancestry at greatest risk and associated lethality. Lack of representation in genomic data means germline testing guidelines exclude for African men. Established that structural variations (SVs) are major contributors to human disease and prostate tumourigenesis, their role is under-appreciated in familial and therapeutic testing. Utilising a clinico-methodologically matched African (n = 113) versus European (n = 57) deep-sequenced PCa resource, we interrogated 42,966 high-quality germline SVs using a best-fit pathogenicity prediction workflow. We identified 15 potentially pathogenic SVs representing 12.4% African and 7.0% European patients, of which 72% and 86% met germline testing standard-of-care recommendations, respectively. Notable African-specific loss-of-function gene candidates include DNA damage repair MLH1 and BARD1 and tumour suppressors FOXP1, WASF1 and RB1. Representing only a fraction of the vast African diaspora, this study raises considerations with respect to the contribution of kilo-to-mega-base rare variants to PCa pathogenicity and African associated disparity.

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Section: Discussionmentioning

confidence: 99%

Rare pathogenic structural variants show potential to enhance prostate cancer germline testing for African men

Hayes,

Gong,

Jiang

et al. 2024

Preprint

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“…Huang et al demonstrated that primary tumors that had not metastasized had relatively more mast cells than metastatic tumors [ 86 ]. They analyzed metastasis-related genes such as adenylate kinase-8 (AK8) and myelin protein zero (MPZ) and found that both AK8 and MPZ were associated with activated mast cells in these samples.…”

Section: Immune Microenvironment In Carcinosarcomamentioning

confidence: 99%

Molecular Characterizations of Gynecologic Carcinosarcomas: A Focus on the Immune Microenvironment

Borrego

Lengyel

Kurnit

2022

Cancers

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Gynecologic carcinosarcomas, specifically of endometrial and ovarian origin, are aggressive and rare tumors. Treatment data are limited and are often extrapolated from other histologies and smaller retrospective studies. While the optimal therapy approach remains contentious, treatment is often multimodal and may include surgery, chemotherapy, radiation, or a combination of multiple strategies. However, despite aggressive treatment, these tumors fare worse than carcinomas of the same anatomic sites irrespective of their stage. Recent studies have described in-depth molecular characterizations of gynecologic carcinosarcomas. Although many molecular features mirror those seen in other uterine and ovarian epithelial tumors, the high prevalence of epithelial-mesenchymal transition is more unique. Recently, molecular descriptions have expanded to begin to characterize the tumor immune microenvironment. While the importance of the immune microenvironment has been well-established for other tumor types, it has been less systematically explored in gynecologic carcinosarcomas. Furthermore, the use of immunotherapy in patients with gynecologic carcinosarcomas has not been extensively evaluated. In this review, we summarize the available data surrounding gynecologic carcinosarcomas, with a focus on the immune microenvironment. We end with a discussion of potential immunotherapy uses and future directions for the field.

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Granulocytes and mast cells in AllergoOncology—Bridging allergy to cancer: An EAACI position paper

Pascal,

Bax,

Bergmann

et al. 2024

Allergy

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Derived from the myeloid lineage, granulocytes, including basophils, eosinophils, and neutrophils, along with mast cells, play important, often disparate, roles across the allergic disease spectrum. While these cells and their mediators are commonly associated with allergic inflammation, they also exhibit several functions either promoting or restricting tumor growth. In this Position Paper we discuss common granulocyte and mast cell features relating to immunomodulatory functions in allergy and in cancer. We highlight key mechanisms which may inform cancer treatment and propose pertinent areas for future research. We suggest areas where understanding the communication between granulocytes, mast cells, and the tumor microenvironment, will be crucial for identifying immune mechanisms that may be harnessed to counteract tumor development. For example, a comprehensive understanding of allergic and immune factors driving distinct neutrophil states and those mechanisms that link mast cells with immunotherapy resistance, might enable targeted manipulation of specific subpopulations, leading to precision immunotherapy in cancer. We recommend specific areas of investigation in AllergoOncology and knowledge exchange across disease contexts to uncover pertinent reciprocal functions in allergy and cancer and allow therapeutic manipulation of these powerful cell populations. These will help address the unmet needs in stratifying and managing patients with allergic diseases and cancer.

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Co-expression Analysis of Genes and Tumor-Infiltrating Immune Cells in Metastatic Uterine Carcinosarcoma

Cited by 3 publications

References 36 publications

Rare pathogenic structural variants show potential to enhance prostate cancer germline testing for African men

Rare pathogenic structural variants show potential to enhance prostate cancer germline testing for African men

Molecular Characterizations of Gynecologic Carcinosarcomas: A Focus on the Immune Microenvironment

Granulocytes and mast cells in AllergoOncology—Bridging allergy to cancer: An EAACI position paper

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