Co-expression of Ki-67 and p53 protein in ameloblastoma and keratocystic odontogenic tumor

Gadbail, Amol R.; Patil, Rahul; Chaudhary, Minal

doi:10.3109/00016357.2011.600714

Cited by 34 publications

(32 citation statements)

References 34 publications

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“…Studies comparing the proliferation rate between dentigerous cysts and ameloblastomas have generated conflicted results, which may reflect differences in the markers and criteria used for the cellular proliferation assessment. Gadbail et al found a significantly higher Ki-67 labeling index in ameloblastomas than in dentigerous cysts (46). Also, in another study, Ki-67 expression was observed to be higher in ameloblastomas that arise from dentigerous cysts than in the dentigerous cysts (47).…”

Section: A B C D E F G Hmentioning

confidence: 87%

Odontogenic epithelial proliferation is correlated with COX-2 expression in dentigerous cyst and ameloblastoma

Alsaegh

Matsumoto

Taniguchi

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Investigation of cyclooxygenase (COX)-2 in dentigerous cyst and ameloblastoma may help to improve understanding of the nature and behavior of odontogenic cysts and tumors, and in addition may eventually represent a definitive target for a pharmacological approach in the management of these lesions. The aim of this study was to evaluate COX-2 expression and its correlation with the proliferation of odontogenic epithelium in these lesions. Dentigerous cysts (n=16) and ameloblastomas (n=17) were evaluated. Detection of Ki-67 and COX-2 protein expression was conducted by immunohistochemistry. Data were statistically analyzed using Mann-Whitney U test and Spearman's rank correlation coefficient. No significant differences were found in the expression of Ki-67 and COX-2 between dentigerous cysts and ameloblastomas (P>0.05). A significant positive correlation (P= 0.018) and highly significant positive correlation (P=0.004) were found between Ki-67 and COX-2 expression in the odontogenic epithelium of dentigerous cyst and ameloblastoma, respectively. COX-2 was expressed in the odontogenic epithelium of dentigerous cyst and ameloblastoma. It may contribute to local extension of these lesions by increasing the proliferation of their odontogenic epithelial cells.

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Section: A B C D E F G Hmentioning

confidence: 87%

Odontogenic epithelial proliferation is correlated with COX-2 expression in dentigerous cyst and ameloblastoma

Alsaegh

Matsumoto

Taniguchi

et al. 2016

Experimental and Therapeutic Medicine

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“…However, not all cells containing the Ki-67 antigen are actively proliferating cells, and the use of Ki-67 to assess proliferative activity is not advised in tissues over expressing p53 or p21 [28]. It should further be noted that correlation between mitotic and Ki-67 labeling indices is variable [29][30][31][32][33][34].…”

Section: Discussionmentioning

confidence: 99%

Ki-67 immunohistochemical expression in mandibular ameloblastoma: A prognostic indicator for local recurrence

Hegab¹,

Shuman²,

El-Akher³

et al. 2013

OJST

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Objective: This study used Ki-67 to evaluate the proliferative activity of ameloblastoma in an attempt to provide a scientific basis for any differences in the biologic behaviour that exists between the different types of ameloblastoma and correlate the results with the recurrence rate. Study design: We assessed Ki-67 expression by immunohistochemistry in 32 cases of mandibular ameloblastoma. Formalin-fixed, paraffinembedded blocks were sectioned and used for Haematoxylin & Eosin (H&E) staining. H&E slides were used to re-evaluate the histological types of the ameloblastoma. Immunohistochemical analysis for Ki-67 with a labelled streptavidin-biotin-peroxidase complex technique was performed on tumour sections using Monoclonal Mouse Anti-Human Ki-67 Antigen (clones MIB1, code M7240, Dako Corporation). Lymph nodes (lymphoma) were used as positive control for Ki-67. Results: The specimens comprised 18 cases of Follicular ameloblastoma, 7 cases of Cystic ameloblastoma, 4 cases of plexiform ameloblastoma, and 3 cases of Acanthotic ameloblastoma. The results showed that cellular proliferative activity varied within the ameloblastoma types. There was no statistically significant difference in the Ki-67 Acanthotic, cystic and follicular types of ameloblastoma, while plexiform type showed statistically significantly higher levels than the other 3 types. The mean Ki-67 labelling index of plexiform ameloblastoma ranged from 13 to 30 with a mean of 19.75. The mean values of Ki-67 were statistically significantly higher in recurrent than non-recurrent cases. Conclusion: The significant expression of Ki-67 could provide useful prognostic markers for proliferative activity and good prognostic indicators for recurrence rate of mandibular ameloblastoma.

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“…Os autores concluíram que é possível que o comportamento biológico do TOC pode estar relacionado com a região suprabasal proliferativa no epitélio cístico, observado pelos altos níveis de Ki-67 e p53. Por outro lado, Gadbail et al (12) verificaram uma maior positividade do Ki-67 e do p53 em ameloblastomas do que em TOC. Esses resultados sugerem que o aumento da expressão do p53 não necessariamente implicaria associação apenas com lesões odontogênicas malignas (23) , mas uma tendência de ser expressa em lesões císticas e TOs mais agressivos, podendo promover a proliferação celular nessas lesões (12) .…”

Section: Proliferação Celularunclassified

“…A atividade proliferativa dessas células também tem sido relatada como importante marcador prognóstico e indicador de agressividade biológica. A atividade proliferativa de uma neoplasia vem sendo normalmente avaliada por meio da mensuração da proporção de células comprometidas com o ciclo celular, de modo a avaliar o potencial de crescimento intrínseco da lesão (12) . Em TOs, têm-se investigado a imunolocalização de proteínas do ciclo celular associadas a essas lesões.…”

Section: Introductionunclassified

Expressão de MMPs, marcadores angiogênicos e proliferação celular em tumores odontogênicos

Matos¹,

Vasconcelos²,

Queiroz³

et al. 2012

J. Bras. Patol. Med. Lab.

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Introdução e objetivo: O conhecimento do comportamento biológico de lesões de natureza odontogênica é essencial para tornar a abordagem terapêutica adequada e estabelecer um prognóstico. A produção de metaloproteinases da matriz extracelular (MMPs), a angiogênese e a proliferação celular fornecem subsídios para o crescimento tumoral. O presente artigo tem como objetivo fazer uma revisão de literatura de pesquisas em tumores odontogênicos (TOs) selecionados a partir da nova classificação da Organização Mundial da Saúde (OMS) de 2005 sobre a expressão de MMPs, marcadores angiogênicos e proliferação celular e verificar, nestes estudos, a relação desses marcadores quanto ao comportamento biológico dessas lesões. Resultados: Nota-se que as MMPs -1, -2, -7, -9 e -26 encontram-se mais expressas no componente epitelial e estroma e, particularmente, a -13 em estroma. Uma maior angiogênese é observada em TOs mais agressivos. CD 105 foi mais expresso no TO ceratocístico (TOC) e CD34 em ameloblastomas sólidos (ASs). Relata-se elevada expressão do Ki-67 e p53 no TOC e no AS e baixo índice de proliferação celular no TO adenomatoide (TOA). Conclusão: Esses resultados mostram que as MMPs participam no processo de invasão e recorrência de algumas lesões odontogênicas, estando associadas ao comportamento biológico desses tumores. A angiogênese é fundamental para fornecer suporte à proliferação celular e esses dois eventos em conjunto estão correlacionados com diferentes níveis de comportamento biológico nos TOs, quando comparados com cistos de natureza odontogênica, o que pode sugerir o uso de inibidores angiogênicos como provável abordagem terapêutica nessas lesões. (WHO-2005) by evaluating the expression of MMPs, angiogenic and cell proliferation. Furthermore, it aims to verify the relation between these markers and the biological behavior of these lesions. Results: it was found that Introduction and objective: The study of biological behavior of odontogenic lesions is essential to the establishment of appropriate therapeutic approach and prognosis. The production of extracellular matrix metalloproteinases (MMPs), angiogenesis and cell proliferation contribute to tumor growth. This paper aims to review the literature on odontogenic tumors (OT) selected according to the new World Health Organization classification

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Co-expression of Ki-67 and p53 protein in ameloblastoma and keratocystic odontogenic tumor

Cited by 34 publications

References 34 publications

Odontogenic epithelial proliferation is correlated with COX-2 expression in dentigerous cyst and ameloblastoma

Odontogenic epithelial proliferation is correlated with COX-2 expression in dentigerous cyst and ameloblastoma

Ki-67 immunohistochemical expression in mandibular ameloblastoma: A prognostic indicator for local recurrence

Expressão de MMPs, marcadores angiogênicos e proliferação celular em tumores odontogênicos

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