Co-expression of Twist and Snai1: predictor of poor prognosis and biomarker of treatment resistance in untreated prostate cancer

Said, Rahma; Hernández-Losa, Javier; Moline, Teresa; de Haro, Rosa Somoza Lopez; Zouari, Skander; Blel, Ahlem; Rammeh, Soumaya; Derouiche, Amine; Ouerhani, Slah

doi:10.1007/s11033-023-09167-w

Cited by 1 publication

(1 citation statement)

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“… 13 Increasing evidence suggests that both EMT‐TFs such as Snail and Twist as well as EMT‐related signaling pathways including TGF‐β, Wnt, and Notch are correlated with the therapeutic resistance. 5 , 210 , 211 Here, we summarize the EMP‐induced resistance to chemotherapy and targeted therapy as well as the implications of EMP in immune evasion and immunotherapy resistance.…”

Section: Emp and Therapeutic Resistancementioning

confidence: 99%

Epithelial–mesenchymal plasticity in cancer: signaling pathways and therapeutic targets

Wang,

Xue,

Pang

et al. 2024

MedComm

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Currently, cancer is still a leading cause of human death globally. Tumor deterioration comprises multiple events including metastasis, therapeutic resistance and immune evasion, all of which are tightly related to the phenotypic plasticity especially epithelial–mesenchymal plasticity (EMP). Tumor cells with EMP are manifest in three states as epithelial–mesenchymal transition (EMT), partial EMT, and mesenchymal–epithelial transition, which orchestrate the phenotypic switch and heterogeneity of tumor cells via transcriptional regulation and a series of signaling pathways, including transforming growth factor‐β, Wnt/β‐catenin, and Notch. However, due to the complicated nature of EMP, the diverse process of EMP is still not fully understood. In this review, we systematically conclude the biological background, regulating mechanisms of EMP as well as the role of EMP in therapy response. We also summarize a range of small molecule inhibitors, immune‐related therapeutic approaches, and combination therapies that have been developed to target EMP for the outstanding role of EMP‐driven tumor deterioration. Additionally, we explore the potential technique for EMP‐based tumor mechanistic investigation and therapeutic research, which may burst vigorous prospects. Overall, we elucidate the multifaceted aspects of EMP in tumor progression and suggest a promising direction of cancer treatment based on targeting EMP.

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