Co-expression profiling of plasma miRNAs and long noncoding RNAs in gastric cancer patients

Ghaedi, Hamid; Mozaffari, Mohammad Amin Nazer; Salehi, Zaker; Ghasemi, Hassan; Zadian, Seyed Sajjad; Alipoor, Sadegh; Hadianpour, Shiva; Alipoor, Behnam

doi:10.1016/j.gene.2018.11.034

Cited by 32 publications

(22 citation statements)

References 33 publications

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“…CeRNA functions as a vital regulatory mechanism in DN [19,20]. StarBase v2.0 (http://starbase.sysu.edu.cn/index.php) was used to predict the potential target miRNA of MEG3.…”

Section: Resultsmentioning

confidence: 99%

Long non-coding RNA MEG3 promotes fibrosis and inflammatory response in diabetic nephropathy via miR-181a/Egr-1/TLR4 axis

Zhang

Tang

et al. 2019

Aging

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Long non-coding RNAs (lncRNAs) play vital roles in diabetic nephropathy (DN). This research aimed to study the potential role and underlying molecular mechanisms of long non-coding RNA MEG3 in DN. We found that MEG3 was upregulated in DN in vivo and in vitro and could enhance cell fibrosis and inflammatory response in DN. MEG3 functioned as an endogenous sponge for miR-181a in mesangial cells (MCs) via direct targeting and in an Ago2-dependent manner. MiR-181a inhibition promoted MC fibrosis and inflammatory response. In addition, Egr-1 was confirmed as a target gene of miR-181a. Further investigations verified that MEG3 promotes fibrosis and inflammatory response via the miR-181a/Egr-1/TLR4 axis in vitro and in vivo. These results provide new insights into the regulation between MEG3 and the miR-181a/Egr-1/TLR4 signaling pathway during DN progression.

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“…CeRNA functions as a vital regulatory mechanism in DN [19,20]. StarBase v2.0 (http://starbase.sysu.edu.cn/index.php) was used to predict the potential target miRNA of MEG3.…”

Section: Resultsmentioning

confidence: 99%

Long non-coding RNA MEG3 promotes fibrosis and inflammatory response in diabetic nephropathy via miR-181a/Egr-1/TLR4 axis

Zhang

Tang

et al. 2019

Aging

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“…We also report a correlation between serum H19 and AMH, a marker of follicular response during IVF 23 . Circulating H19 has been explored as a diagnostic and prognostic biomarker for other conditions including coronary artery disease [43], multiple myeloma [44], and cancers including bladder and gastric cancer [22,40,41,45,46]. In the reproductive tract, circulating H19 is higher in women with polycystic ovary syndrome (PCOS) compared to controls [47], and H19 has been identified as a potential diagnostic and prognostic marker for epithelial ovarian [48] and cervical cancer [49].…”

Section: Discussionmentioning

confidence: 99%

The relationship between H19 and parameters of ovarian reserve

Xia

Burn

Chen

et al. 2020

Reprod Biol Endocrinol

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Context: The H19 long noncoding RNA (lncRNA) belongs to a highly conserved, imprinted gene cluster involved in embryonic development and growth control. We previously described a novel mechanism whereby the Antimullerian hormone (Amh) appears to be regulated by H19. However, the relationship between circulating H19 and markers of ovarian reserve including AMH not been investigated. Objective: To determine whether H19 expression is altered in women with decreased ovarian reserve.

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“…MicroRNAs (miRNAs), are a member of noncoding RNAs, that are highly conservative small RNAs with about 20–22 nucleotides. miRNAs widely exist in multiple cellular organisms and involve in almost all processes of vital activities (Yan et al, ) Numerous studies on the relationship between miRNAs and tumors conducted by scientists have indicated that miRNAs are important in many tumors such as GC, lung cancer, colon cancer, prostatic cancer, thyroid cancer, breast cancer (Ghaedi et al, ; Qi et al, ). For LncRNAs, the modes of action include binding to proteins, chromosome and other macromolecules and involvement in the regulatory network of competing endogenous RNA (ceRNA) (Salmena, Poliseno, Tay, Kats, & Pandolfi, ).…”

Section: Discussionmentioning

confidence: 99%

Lnc‐GIHCG promotes cell proliferation and migration in gastric cancer through miR‐ 1281 adsorption

Liu

Jiang

Qiao

et al. 2019

Molec Gen & Gen Med

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Background Long noncoding RNAs (lncRNAs) are from the family of noncoding RNAs. Existing studies have shown that lncRNAs are involved in many biological processes and are strongly related to the occurrence and development of tumors. Recent studies have indicated that lncRNA GIHCG participates in the progression of many cancers by adjusting cell proliferation and migration. Gastric cancer (GC) is a prevalent malignant tumor that arises from gastric epithelium. This study mainly explored the influence of GIHCG on GC and its underlying mechanism. Methods GIHCG expression was detected in GC through quantitative real‐time polymerase chain reaction while the relationship of GIHCG with miR‐1281 and miR‐1281 with TLE1 was verified using dual luciferase reporter gene assay. The influence of GIHCG, miR‐1281 and TLE1 on cell function was verified using cell counting Kit‐8 (CCK‐8) and Transwell experiment. Results In GC, GIHCG was significantly overexpressed and significantly increased cell proliferation and migration, with the possible mechanism of upregulatingTLE1 expression through adsorption of miR‐1281. Conclusion Taken together, we revealed the role of GIHCG/miR‐1281/TLE1 in GC and provided a new perspective.

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Co-expression profiling of plasma miRNAs and long noncoding RNAs in gastric cancer patients

Cited by 32 publications

References 33 publications

Long non-coding RNA MEG3 promotes fibrosis and inflammatory response in diabetic nephropathy via miR-181a/Egr-1/TLR4 axis

Long non-coding RNA MEG3 promotes fibrosis and inflammatory response in diabetic nephropathy via miR-181a/Egr-1/TLR4 axis

The relationship between H19 and parameters of ovarian reserve

Lnc‐GIHCG promotes cell proliferation and migration in gastric cancer through miR‐ 1281 adsorption

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