Co(II) complexes derived from (1-methyl-1H-imidazol-2-yl)methanol: Synthesis, characterization, spectroscopic study, DFT/TD-DFT calculations and biological evaluation

Benhassine, Anfel; Boulebd, Houssem; Anak, Barkahem; Ali, Mounira Kara; Bouraiou, Abdelmalek; Mérazig, Hocine; Kacem-Chaouche, Noureddine; Belfaitah, Ali

doi:10.1016/j.ica.2019.119073

Cited by 9 publications

(2 citation statements)

References 44 publications

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“…The iiα-glucosidase iiinhibitory iiefficiency iiwas performed iiusing iimodified iimethodology iiof iiPistia Brueggeman iiand Hollingsworth ii [Benhassine A, Boulebd H, Anak B, Ali MK and Belfaitah A, 2019]. iiHere, iithe prepared metal iicomplexes were prepared iiat iivarious concentrations ii(20 iito ii400μg/mL), ii100μL iiphosphate buffer iiand ii10 iiμL iienzyme iiwere iimixed thoroughly and incubated iiat iiRT iifor ii20min.…”

Section: α -Glucosidase Iiinhibitory Iiassaymentioning

confidence: 99%

Synthesis, Structural Characterization, Catalytic, Biological and α-Glucosidase Inhibitory Studies of Metal Complexes with Flavone Derivatives

Jyothi¹,

Vincent²,

Joseph³

2021

alinteri

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Heterocyclic compounds, in particular oxygen-containing heterocyclic compounds, are of special interest to medicinal chemists because of their unusual biological properties. In the present study, the highly conjugated nitrogen heterocyclic scaffold comprised of flavone derivative with metal acetates to form metal chelates of the type [MIIL(OAc)2], flavone analogues (L); M=Co2+, Zn2+, Cu2+ and Ni2+. The above title compounds were characterized using composition analysis o fCHN and spectroscopic techniques. Based on spectroscopic and analytical measurements confirmed that square planar arrangements for the Co2+, Zn2+, Cu2+ and Ni2+ complexes. Antimicrobial efficacy of prepared complexes were assessed against A.flavus, A.niger, B.subtilis, E. coli, C. albicans and S.aureus. The anti-mycobacterial (H37Rv) efficacy of flavone analogues and its complexes were screened using MABA approach and compared with standard. The acetylcholinesterase (AChE) inhibitory effect of the ligand was examined to find out the therapeutic efficiency of compound in the treatment of neurodegenerative disorders. The synthesized ligand exhibited selective inhibition (AChE & BuChe) values (IC50:0.20(flavone analogue), 2.41 (Rivastigmine) and 3.01 µM (Galantamine), respectively. Further, the in vitro ant-inflammatory efficiency of metal chelates were performed with the help of egg albumin method. The α-glucosidase inhibition activity was also carried out for the prepared metal complexes.

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Section: α -Glucosidase Iiinhibitory Iiassaymentioning

confidence: 99%

Synthesis, Structural Characterization, Catalytic, Biological and α-Glucosidase Inhibitory Studies of Metal Complexes with Flavone Derivatives

Jyothi¹,

Vincent²,

Joseph³

2021

alinteri

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“…Fluorescent Behavior: Photochromism defines that in the presence of light, the molecules exhibit different absorption spectra with different colors [27][28][29][30][31][32] . This phenomenon attributes different sensing applications [33][34][35][36] .…”

Section: Absorption Spectral Titrationsmentioning

confidence: 99%

Untitled

2020

IJPSR

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Novel metal complexes of ligands of pyrazoline derivatives were synthesized by the condensation of 1-acetyl-2hydroxynapthalene and indole-3-carboxaldehyde followed by the condensation of substituted phenylhydrazine. They were characterized by elemental analysis, IR, 1H-NMR, UV-Vis., molar conductance, magnetic susceptibility measurements and electrochemical studies. Based on the magnetic moment and electronic spectral data, square planar geometry has been suggested for metal complexes. The binding behavior of the complexes with calf thymus DNA has been investigated by electronic absorption spectra and cyclic voltammetry techniques. The DNA binding constants reveal that all these complexes interact with DNA through intercalation binding mode. Superoxide dismutase and antioxidant activities of the copper complexes have also been studied. The antioxidant activities of the complexes showed higher activities. Fluorescent studies reveal that the absorption band is shifted towards visible region indicates that the pyrazoline derivatives of metal complexes may exhibit different emission with respect to suitable substituent present in the pyrazoline structural core. Naphthyl group is responsible for the green colour emission due to its conjugation and electronic delocalization within the molecule and leads to longer wavelength. INTRODUCTION: Metal-containing compounds/ complexes offer many distinct advantages over traditional organic i.e., carbon-based compounds in the development of new medicinal lead molecules due to their capability to coordinate ligands/organic molecules 1-6 .

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Combined experimental and theoretical studies of the structure-antiradical activity relationship of heterocyclic hydrazone compounds

Khodja

Bensouici²,

Boulebd

2020

Journal of Molecular Structure

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Co(II) complexes derived from (1-methyl-1H-imidazol-2-yl)methanol: Synthesis, characterization, spectroscopic study, DFT/TD-DFT calculations and biological evaluation

Cited by 9 publications

References 44 publications

Synthesis, Structural Characterization, Catalytic, Biological and α-Glucosidase Inhibitory Studies of Metal Complexes with Flavone Derivatives

Synthesis, Structural Characterization, Catalytic, Biological and α-Glucosidase Inhibitory Studies of Metal Complexes with Flavone Derivatives

Untitled

Combined experimental and theoretical studies of the structure-antiradical activity relationship of heterocyclic hydrazone compounds

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