2024
DOI: 10.1021/acs.orglett.4c01686
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Co(III)-Catalyzed Regioselective Functionalization of Isoquinolones with Naphthoquinones

Tamanna Sharma,
Sumit,
Sachin
et al.

Abstract: A strategy for Co(III)-catalyzed C(sp2)–H alkenylation of N-protected isoquinolones with 1,4-naphthoquinones has been disclosed. The developed protocol was efficiently applied for diversely substituted isoquinolones. Preliminary mechanistic experiments revealed the involvement of a five-membered cobaltacycle as an intermediate. Deuterium labeling experiments suggested the reversible nature of the C–H activation step. The scale-up reaction was also carried out, and the product was utilized as a chemosensor to d… Show more

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