Co(III), Ni(II), Zn(II) and Cd(II) complexes with 2-acetyl-2-thiazoline thiosemicarbazone: Synthesis, characterization, X-ray structures and antibacterial activity

Viñuelas-Zahı́nos, E.; Luna‐Giles, F.; Torres-García, P.; Fernández-Calderón, María Coronada

doi:10.1016/j.ejmech.2010.10.030

Cited by 66 publications

(19 citation statements)

References 41 publications

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“…The C(1)-S(1) distance (1.6814 Å) is similar to that found in a methyl analogue of 2-acetyl-2-thiazoline thiosemicarbazone which is in the thione form as a solid. [13] AcetylethTSC adopts a syn conformation about the N1–N2 bond in a similar fashion as those thiosemicarbazones that were formed from 2-acetylthiazole as reported by Venkatraman et al . [14] The N2-H group donates an intermolecular hydrogen bond to thione S1, while forming centrosymmetric hydrogen-bonded dimers with N…S distance 3.4651(15) Å. Thiazole N atom N4 is not involved in hydrogen bonding as shown in Figure 2.…”

Section: Resultssupporting

confidence: 58%

Synthesis, Characterisation, and Preliminary In Vitro Studies of Vanadium(IV) Complexes with a Schiff Base and Thiosemicarbazones as Mixed Ligands

et al. 2011

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[VO(Sal-L-tryp)(H2O)] 1 (where sal-L-tryp = N-salicylidene-L-tryptophanate) was used as a precursor to produce the novel complexes, [VO(Sal-L-tryp)(MeATSC)].1.5C2H5OH 2 (where MeATSC = 9-Anthraldehyde-N(4)-methylthiosemicarbazone), [VO(Sal-L-tryp)(N-Ethhymethohcarbthio)].H2O 3 (where N-Ethhymethohcarbthio = (E)-N-ethyl-2-(4-hydroxy-3-methoxybenzylidene)hydrazinecarbothioamide), and [VO(Sal-L-tryp)(acetylethTSC)].C2H5OH 4 (where acetylethTSC = (E)-N-ethyl-2-(1-(thiazol-2-yl)ethylidene)hydrazinecarbothioamide), by reaction with the respective thiosemicarbazone. The chemical and structural properties of these ligands and complexes were characterised by elemental analysis, ESI MS, FT-IR, UV-visible, ESR, 1H and 13C NMR spectroscopy, and X-ray crystallography. DMSO and DMSO-d6 solutions of compounds 1-4 were oxidised in air to produce vanadium(V) species which were verified by ESI MS and 51V NMR spectroscopy. Anti-cancer properties of compounds 2-4 were examined with three colon cancer cell lines, HTC-116, Caco-2, and HT-29, and also with non-cancerous colonic myofibroblasts, CCD18-Co. Compounds 2-3 exhibited less inhibitory effects in the CCD-18Co cells, indicating a possible cytotoxic selectivity towards colon cancer cells. In general, those compounds which exhibited anti-proliferative activity on cancer cells, but did not affect non-cancerous cells, may have a potential in chemotherapy.

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Section: Resultssupporting

confidence: 58%

Synthesis, Characterisation, and Preliminary In Vitro Studies of Vanadium(IV) Complexes with a Schiff Base and Thiosemicarbazones as Mixed Ligands

et al. 2011

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“…Cadmium complexes have attracted more and more attentions because of their widely reported bioactivities, such as DNA binding affinity [17] and antibacterial activities [18]. Meanwhile, the antitumor activities of cadmium(II) complexes have been reported more frequently [19,20], despite the metal was regarded as a human carcinogen.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectral, electrochemical, crystal structure studies of two novel di-μ-halo-bis[halo(2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline)cadmium(II)] dimer complexes and their thermolysis to nanometal oxides

Warad

Abdoh

Naveen

et al. 2015

Journal of Molecular Structure

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“…12 In this context, thiazolines are a class of ligands formed by heterocyclic five-membered rings that contain nitrogen and sulfur atoms, which have a plurality of coordination modes. 13 Thiazolines are known for various biological activities such as anti-inflammatory, 14 anticancer 15 and antimicrobial, 16 which make the thiazoline-derived compounds important in medicinal chemistry studies. Therefore, compounds derived from 2-thiazolidine-2-thiol have been synthesized and used in metal complexes formation [16][17][18] such as the 2-thiazoline-2-thiol-derivative ligand 19 that is included in a class of ligands called scorpionates.…”

Section: Introductionmentioning

confidence: 99%

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NEW Cu (II), Co (II) AND Sn (II) COMPLEXES WITH THE SODIUM HYDROTRIS(2-MERCAPTOTHIAZOLYL)BORATE LIGAND

Ferreira¹,

Andrade²,

Lima³

et al. 2020

Quim. Nova

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Recebido em 27/11/2019; aceito em 05/02/2020; publicado na web em 16/04/2020 The emergence of antibiotic resistance among microbial pathogens is a serious public health problem, resulting in a constant need of discovering new antibiotics. For this purpose, we synthetized and determined the antimicrobial activity of copper (Cu), cobalt (Co), and tin (Sn) complexes coordinated with scorpionate ligand in a tridentate mode against microorganisms of clinical importance. New complexes with the sodium hydrotris(2-mercaptothiazolyl)borate ligand were characterized by physicochemical and spectroscopic techniques (UV-vis, IR, 1 H and 13 C NMR). Moreover, their antimicrobial activity was evaluated using microdilution broth method. Cytotoxicity was determined in Vero cells and the selectivity index (SI) was calculated. The coordination with metals increased the ligand antimicrobial activity, which showed no activity when evaluated alone (MIC>1,080 µM). Cu-complex (1) had activity against Candida albicans and C. krusei, with MICs of 130 and 66 µM, respectively. The compounds had low toxicity on Vero cells and chemo-informatics assays corroborated a low systemic toxic effect. The SI revealed that the compound 1 was 16 times more selective for C. krusei and 8 times more selective for C. albicans in relation to Vero cells. The Cu-complex stands out as a potential prototype for the development of new antifungal agents.

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Co(III), Ni(II), Zn(II) and Cd(II) complexes with 2-acetyl-2-thiazoline thiosemicarbazone: Synthesis, characterization, X-ray structures and antibacterial activity

Cited by 66 publications

References 41 publications

Synthesis, Characterisation, and Preliminary In Vitro Studies of Vanadium(IV) Complexes with a Schiff Base and Thiosemicarbazones as Mixed Ligands

Synthesis, Characterisation, and Preliminary In Vitro Studies of Vanadium(IV) Complexes with a Schiff Base and Thiosemicarbazones as Mixed Ligands

Synthesis, spectral, electrochemical, crystal structure studies of two novel di-μ-halo-bis[halo(2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline)cadmium(II)] dimer complexes and their thermolysis to nanometal oxides

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NEW Cu (II), Co (II) AND Sn (II) COMPLEXES WITH THE SODIUM HYDROTRIS(2-MERCAPTOTHIAZOLYL)BORATE LIGAND

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