Co-induction of p75NTR and the associated death executor NADE in degenerating hippocampal neurons after kainate-induced seizures in the rat

Yi, Jung-Sun; Lee, Soon-Keum; Sato, Takaaki; Koh, Jae‐Young

doi:10.1016/s0304-3940(03)00656-6

Cited by 21 publications

(11 citation statements)

References 20 publications

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“…p75 has been shown to mediate a variety of neurotrophin effects including promotion of neuronal survival as well as apoptosis [3,17]. The result of this study that no significant neuronal death could be induced by axotomy, corresponding to the reexpression of p75 in PN14 and adult rats, excludes the possibility that p75 is involved in neuronal apoptosis.…”

Section: Discussionmentioning

confidence: 71%

Age-related reexpression of p75 in axotomized motoneurons

Yuan

Hu²,

So³

et al. 2006

NeuroReport

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p75 was immunohistochemically identified in spinal motoneurons in immature and adult rats after either distal peripheral axotomy or root avulsion. Few or no p75 positive motoneurons were observed after distal axotomy in animals at the age of postnatal day 1 and postnatal day 7, whereas the injury induced marked neuronal death. Motoneurons reexpressed p75 from the end of the second postnatal week to adulthood in response to distal axotomy, whereas most motoneurons survived after the injury. On the other hand, root avulsion in animals of all ages did not cause significant p75 expression in avulsed motoneurons where most motoneurons died ultimately. The potential role of such reexpression in motoneuron protection is discussed.

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Section: Discussionmentioning

confidence: 71%

Age-related reexpression of p75 in axotomized motoneurons

Yuan

Hu²,

So³

et al. 2006

NeuroReport

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“…This finding contrasts with mouse Bex3, which has five repeats and with human Bex3 which has no repeats. The ability of rat Bex3 to bind transition metals may be important since mouse Bex3 and zinc appear to play a role in cell death in animal models of seizure and ischemia (Park et al, 2000;Yi et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Characterization of the Bex gene family in humans, mice, and rats

Alvarez

Zhou

Witta

et al. 2005

Gene

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“…Other p75 NTR -interacting proteins may also be involved in p75 NTR -mediated apoptotic signaling after seizures. The adapter protein NADE can be co-induced with p75 NTR following kainate-induced seizures (Yi and others 2003), and may also play a role in cell death signaling. In addition, NRAGE has been detected in a complex with NRIF following proNGF stimulation (Volosin and others 2008); therefore, rather than activating independent pathways, some of these p75 NTR adapter proteins may act together in a complex to stimulate downstream signaling.…”

Section: Mechanisms Of P75ntr-mediated Neuronal Apoptosismentioning

confidence: 99%

Proneurotrophins, Seizures, and Neuronal Apoptosis

Friedman

2010

Neuroscientist

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Neurons respond to numerous factors in their environment that influence their survival and function during development and in the mature brain. Among these factors, the neurotrophins have been shown to support neuronal survival and function, acting primarily through the Trk family of receptor tyrosine kinases. However, recent studies have established that the uncleaved neurotrophin precursors, the proneurotrophins, can be secreted and induce apoptosis via the p75 neurotrophin receptor, suggesting that the balance of secreted mature and proneurotrophins has a critical impact on neuronal survival or death. Epileptic seizures elicit increases in both proneurotrophin secretion and p75NTR expression, shifting the balance of these factors toward signaling cell death. This review will discuss the evidence that this ligand-receptor system plays an important role in neuronal loss following seizures.

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Co-induction of p75NTR and the associated death executor NADE in degenerating hippocampal neurons after kainate-induced seizures in the rat

Cited by 21 publications

References 20 publications

Age-related reexpression of p75 in axotomized motoneurons

Age-related reexpression of p75 in axotomized motoneurons

Characterization of the Bex gene family in humans, mice, and rats

Proneurotrophins, Seizures, and Neuronal Apoptosis

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