Co-infection of human parvovirus B19 with Plasmodium falciparum contributes to malaria disease severity in Gabonese patients

Toàn, Nguyễn Lĩnh; Sy, Bui Tien; Song, Lê Hữu; Luong, Hoang Van; Binh, N.; Binh, Vu Q.; Kandolf, Reinhard; Velavan, Thirumalaisamy P.; Kremsner, Peter G.; Bock, C.‐Thomas

doi:10.1186/1471-2334-13-375

Cited by 21 publications

(15 citation statements)

References 46 publications

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“…In children with only sub-microscopic parasitemia, it is uncertain whether fevers can be ascribed to malaria, and in fact many children had both P. falciparum and additional microbes identified. Interestingly, three of the four cases of parvovirus B19 were found in association with P. falciparum; this co-infection has been associated with severe anemia with life-threatening consequences [42][43][44].…”

Section: Discussionmentioning

confidence: 99%

Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda

et al. 2019

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Febrile illness is a major burden in African children, and non-malarial causes of fever are uncertain. In this retrospective exploratory study, we used metagenomic next-generation sequencing (mNGS) to evaluate serum, nasopharyngeal, and stool specimens from 94 children (aged 2–54 months) with febrile illness admitted to Tororo District Hospital, Uganda. The most common microbes identified were Plasmodium falciparum (51.1% of samples) and parvovirus B19 (4.4%) from serum; human rhinoviruses A and C (40%), respiratory syncytial virus (10%), and human herpesvirus 5 (10%) from nasopharyngeal swabs; and rotavirus A (50% of those with diarrhea) from stool. We also report the near complete genome of a highly divergent orthobunyavirus, tentatively named Nyangole virus, identified from the serum of a child diagnosed with malaria and pneumonia, a Bwamba orthobunyavirus in the nasopharynx of a child with rash and sepsis, and the genomes of two novel human rhinovirus C species. In this retrospective exploratory study, mNGS identified multiple potential pathogens, including 3 new viral species, associated with fever in Ugandan children.

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Section: Discussionmentioning

confidence: 99%

Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda

et al. 2019

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“…However, both seals were co-infected with Phocine herpesvirus-1. Of interest, co-infection of humans with various pathogens and parvovirus B19 has been associated with progression to more severe disease previously [34–36]. The role of Seal parvovirus in the disease of the two other animals remained uncertain and should be the focus of additional studies.…”

Section: Discussionmentioning

confidence: 99%

Novel B19-Like Parvovirus in the Brain of a Harbor Seal

Bodewes

García²,

Wiersma

et al. 2013

PLoS ONE

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Using random PCR in combination with next-generation sequencing, a novel parvovirus was detected in the brain of a young harbor seal (Phoca vitulina) with chronic non-suppurative meningo-encephalitis that was rehabilitated at the Seal Rehabilitation and Research Centre (SRRC) in the Netherlands. In addition, two novel viruses belonging to the family Anelloviridae were detected in the lungs of this animal. Phylogenetic analysis of the coding sequence of the novel parvovirus, tentatively called Seal parvovirus, indicated that this virus belonged to the genus Erythrovirus, to which human parvovirus B19 also belongs. Although no other seals with similar signs were rehabilitated in SRRC in recent years, a prevalence study of tissues of seals from the same area collected in the period 2008-2012 indicated that the Seal parvovirus has circulated in the harbor seal population at least since 2008. The presence of the Seal parvovirus in the brain was confirmed by real-time PCR and in vitro replication. Using in situ hybridization, we showed for the first time that a parvovirus of the genus Erythrovirus was present in the Virchow-Robin space and in cerebral parenchyma adjacent to the meninges. These findings showed that a parvovirus of the genus Erythrovirus can be involved in central nervous system infection and inflammation, as has also been suspected but not proven for human parvovirus B19 infection.

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“…B19 infection in patients with chronic hemolysis, such as sickle cell disease, can evolve into aplastic crises and bone marrow necrosis. Likewise, rates of B19 infection are 10-fold higher in malaria patients (14.2% versus 1.2%; P Ͻ 0.0001), and B19 contributes to anemia severity (477). In organ transplant patients, acute and chronic B19 infections have been reported in 18 to 31% of patients and can compromise long-term organ function (478)(479)(480).…”

Section: Parvovirus B19mentioning

confidence: 99%

Blood Groups in Infection and Host Susceptibility

2015

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SUMMARY Blood group antigens represent polymorphic traits inherited among individuals and populations. At present, there are 34 recognized human blood groups and hundreds of individual blood group antigens and alleles. Differences in blood group antigen expression can increase or decrease host susceptibility to many infections. Blood groups can play a direct role in infection by serving as receptors and/or coreceptors for microorganisms, parasites, and viruses. In addition, many blood group antigens facilitate intracellular uptake, signal transduction, or adhesion through the organization of membrane microdomains. Several blood groups can modify the innate immune response to infection. Several distinct phenotypes associated with increased host resistance to malaria are overrepresented in populations living in areas where malaria is endemic, as a result of evolutionary pressures. Microorganisms can also stimulate antibodies against blood group antigens, including ABO, T, and Kell. Finally, there is a symbiotic relationship between blood group expression and maturation of the gastrointestinal microbiome.

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Co-infection of human parvovirus B19 with Plasmodium falciparum contributes to malaria disease severity in Gabonese patients

Cited by 21 publications

References 46 publications

Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda

Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda

Novel B19-Like Parvovirus in the Brain of a Harbor Seal

Blood Groups in Infection and Host Susceptibility

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