Co-infection of Leptospirosis and Crimean-Congo Hemorrhagic Fever

Abstract

Introduction: Infectious diseases are important factors affected human health over the years. At present, more than 450 diseases are known to be transmitted between animals and human. The Crimean-Congo hemorrhagic fever (CCHF) and leptospirosis are common zoonotic diseases causing fever and systemic illness. Clinical symptoms of CCHF and leptospirosis are often nonspecific; so, they may be mistaken with other infectious diseases. Case Presentation: This article presents a 56-year-old woman from Guilan Province, the north of Iran and the southern coast of the Caspian Sea, who admitted to the hospital with acute fever, severe headache, thrombocytopenia, anemia, epigastric pain, myalgia, nausea and vomiting. Conclusions: We recognized that the case was co-infected by CCHF and leptospirosis.

Application of PCR for Specific Diagnosis of Leptospirosis in Humans in Ukraine

“…However, India is an endemic zone for different hemorrhagic fevers that are characterized by leptospirosis-like symptoms. Coinfection of leptospirosis and Crimean-Congo hemorrhagic fever or hemorrhagic fever with renal syndrome (CCHF, GF with renal syndrome) is common among humans ( Golubić and Markotić 2003 ; Seifi et al 2016 ). Consequently, the lack of research data that would exclude the presence of these diseases or their coexistence did not prevent the authors of this research from confirming that there were patients with leptospirosis diagnosed based on clinical findings during this outbreak.…”

Leptospirosis in Ukraine (Lviv Oblast): Clinical and Epidemiological Features

“…Possible explanations for this difference in mortality include the following: first, in patients who died in early stages of the disease, there may not have been enough time for antibodies to form. Alternatively, some MAT (−) deceased patients could have died from other diseases such as hemorrhagic fever with renal syndrome (HFRS) or Crimean-Congo hemorrhagic fever (CCHF) that have similar presentations (Markotić et al 2002, Golubić and Markotić 2003, Agampodi et al 2011, Seifi et al 2016).…”