Co-infection of Schistosoma mansoni/hepatitis C virus and their associated factors among adult individuals living in fishing villages, north-western Tanzania

Mazigo, Humphrey D.; Kepha, Stella; Kaatano, Godfrey M.; Kinung’hi, Safari

doi:10.1186/s12879-017-2780-3

Cited by 8 publications

(4 citation statements)

References 37 publications

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“…The prevalence observed among fishermen in the Busega district was higher than the prevalence of 51.8% observed among adults living in fishing villages in the Mwanza region [ 14 ]. The variations in prevalence might be due to differences in study populations.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Schistosoma mansoni infection among fishermen in Busega district, Tanzania

Mang’ara¹,

Ngasala

John

2022

PLoS ONE

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Background Schistosoma (S.) mansoni infection is endemic in all regions around Lake Victoria and affects all age groups to different degrees. In most endemic areas, less attention has been paid to determining the prevalence of infection, sanitation status, and knowledge about intestinal schistosomiasis (KIS) in fishermen. Therefore, the purpose of this study was to establish the prevalence of S. mansoni infection and associated factors among fishermen in the Busega district. Materials and methods A cross-sectional study was conducted among fishermen in July, 2020 in five fishing villages in the Busega district located along Lake Victoria. A total of 352 fishermen were interviewed with regard to their sanitation status and level of KIS. A single stool sample from fishermen was examined for S.mansoni eggs by using the Formalin-Ether Concentration technique. The potential factors associated with S. mansoni infection were explored using multivariable logistic regression. Results The prevalence of S. mansoni infection was high (65.0%) among fishermen and varied with age, whereby fishermen aged ≤36 years had the highest prevalence. Fishermen had a low level of KIS and the majority of them reported practicing open defecation during fishing (81%). These fishermen with a low level of KIS and who reported defecating in open areas during fishing had 2.8 times (95% CI: 1.0–7.2) and 2.1 times (95% CI: 1.1–3.9) higher odds of being infected with S. mansoni than those with a high level of KIS and those who did not report defecating in open areas during fishing, respectively. Conclusion S. mansoni infection was high among fishermen in the Busega district. Furthermore, fishermen had a low level of KIS and were reported to have defecated in open areas during fishing. Infection with S. mansoni was associated with age, a low level of KIS and open defecation behaviour during fishing. Therefore, mass drug administration (MDA) with praziquantel, health education, and sanitation behaviour change interventions were needed.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Schistosoma mansoni infection among fishermen in Busega district, Tanzania

Mang’ara¹,

Ngasala

John

2022

PLoS ONE

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“…It is known that treatment with praziquantel cannot halt the progression of organ damage in some individuals. This situation may be due to immunological and genetic factors, as well as other influences, including malaria, viral hepatitis and/or concomitant alcohol consumption [ 5 , 32 – 34 ].…”

Section: Discussionmentioning

confidence: 99%

Morbidity associated with Schistosoma mansoni infection in north-eastern Democratic Republic of the Congo

Nigo

Odermatt

Nigo³

et al. 2021

PLoS Negl Trop Dis

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Background Reducing morbidity is the main target of schistosomiasis control efforts, yet only rarely do control programmes assess morbidity linked to Schistosoma sp. infection. In the Democratic Republic of Congo (DRC), and particularly in north-eastern Ituri Province, little is known about morbidity associated with Schistosoma mansoni infection. For this reason, we aimed to assess intestinal and hepatosplenic morbidity associated with S. mansoni infection in Ituri Province. Methods/Principal findings In 2017, we conducted a cross-sectional study in 13 villages in Ituri Province, DRC. S. mansoni infection was assessed with a Kato-Katz stool test (2 smears) and a point-of-care circulating cathodic antigen (POC-CCA) urine test. A questionnaire was used to obtain demographic data and information about experienced intestinal morbidity. Each participant underwent an abdominal ultrasonography examination to diagnose hepatosplenic morbidity. Of the 586 study participants, 76.6% tested positive for S. mansoni. Intestinal morbidity reported in the two preceding weeks was very frequent, and included abdominal pain (52.7%), diarrhoea (23.4%) and blood in the stool (21.5%). Hepatosplenic morbidity consisted of abnormal liver parenchyma patterns (42.8%), hepatomegaly (26.5%) and splenomegaly (25.3%). Liver pathology (adjusted odds ratio [aOR] 1.20, 95% confidence interval [CI] 1.06–1.37, p = 0.005) was positively and significantly associated with S. mansoni infection. Hepatomegaly (aOR 1.52, 95% CI 0.99–2.32, p = 0.053) and splenomegaly (aOR 1.12, 95% CI 0.73–1.72, p = 0.619) were positively but not significantly associated with S. mansoni infection at the individual level. At the village level, S. mansoni prevalence was positively associated with the prevalence of hepatomegaly and splenomegaly. High-intensity S. mansoni infections were associated with diarrhoea, blood in the stool, hepatomegaly, splenomegaly, and liver parenchyma (C, D, E and F pathology patterns). Four study participants were diagnosed with ascites and five reported hematemesis. Conclusions/Significance Our study documents a high burden of intestinal and hepatosplenic morbidity associated with S. mansoni infection status in Ituri Province. The findings call for targeted interventions to address both S. mansoni infection and related morbidity.

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“…It is also known that treatment with praziquantel could not halt progression of organ damage in some individuals. This situation may be due to immunological and genetic factors as well as other factors, including malaria, viral hepatitis and/or concomitant alcohol consumption [5,[29][30][31].…”

Section: Liver Spleenmentioning

confidence: 99%

Morbidity associated with Schistosoma mansoni infection in north-eastern Democratic Republic of the Congo

Nigo

Odermatt

Nigo

et al. 2020

Preprint

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Background Controlling morbidity is the main target of schistosomiasis control. Yet, only rarely do we assess morbidity linked to Schistosoma sp. infection. In the Democratic Republic of Congo (DRC), and particularly in the northeastern Ituri province, morbidity associated with Schistosoma mansoni infection is unknown. For this reason, we aimed to assess intestinal and hepatosplenic morbidity associated with S. mansoni infection in Ituri province. Methods / Principal Findings In 2017, we conducted a cross sectional study in 13 villages in Ituri province, DRC. S. mansoni infection was assessed with a Kato-Katz stool test (2 smears) and a point-ofcare circulating cathodic antigen (POC CCA) test in urine. A questionnaire was used to obtain demographic data and information about experienced intestinal morbidity. Each participant underwent an abdominal ultrasonography examination to diagnose hepatosplenic morbidity. Of the 586 study participants, 76.6% tested positive for S. mansoni . Intestinal morbidity, such as abdominal pain (52.7%), diarrhoea (23.4%) and blood in the stool (21.5%) in the previous two weeks, was very frequent, as was hepatosplenic morbidity, such as splenomegaly (60.1%), hepatomegaly (23.2%) and abnormal liver parenchyma pattern (52.6%). Hepatomegaly (adjusted odds ratio [aOR] 2.04, 95% confidence interval [CI] 1.27 to 3.26, P =0.003) and splenomegaly (aOR 1.69, 95% CI 1.17 to 2.45, P =0.005) were positively associated with S. mansoni infection at the individual level. At the village level, S. mansoni prevalence was positively associated with the prevalence of hepatomegaly and splenomegaly. Higher S. mansoni infection intensities were associated with diarrhoea, blood in the stool, hepatomegaly, splenomegaly and with liver parenchyma, pathology pattern D-E. Four study participants were diagnosed with ascites and five reported hematemesis. Conclusions/Significance : Our study documents a high burden of intestinal and hepatosplenic morbidity associated with S. mansoni infection status in Ituri province. The results call for targeted interventions to address both S. mansoni infection and related morbidity.

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Co-infection of Schistosoma mansoni/hepatitis C virus and their associated factors among adult individuals living in fishing villages, north-western Tanzania

Cited by 8 publications

References 37 publications

Prevalence of Schistosoma mansoni infection among fishermen in Busega district, Tanzania

Prevalence of Schistosoma mansoni infection among fishermen in Busega district, Tanzania

Morbidity associated with Schistosoma mansoni infection in north-eastern Democratic Republic of the Congo

Morbidity associated with Schistosoma mansoni infection in north-eastern Democratic Republic of the Congo

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