Co-infections due to leptospira, dengue and hepatitis E: a diagnostic challenge

Behera, Bijayini; Chaudhry, Rama; Pandey, Avinash; Dar, Lalit; Premlatha, M. M.; Gupta, Ekta; Broor, Shobha; Aggarwal, P

doi:10.3855/jidc.535

Cited by 35 publications

(30 citation statements)

References 10 publications

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“…On the other hand, concurrent infection of mosquito-borne disease with another waterborne disease, such as dengue fever and hepatitis A infection or malaria with typhoid fever, is quite often reported from different developing countries [26]. Also, co-infections due to Leptospira and HEV were reported from some tropical countries, but this is the first time the co-existence of YF with HEV as outbreaks in our African region was reported [27].…”

Section: Discussionmentioning

confidence: 95%

Concomitant outbreaks of yellow fever and hepatitis E virus in Darfur States, Sudan, 2012

Ahmed

Soghaier

Mohammed

et al. 2016

J Infect Dev Ctries

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Introduction: Yellow fever (YF) is a vector-borne disease transmitted to humans by infected Aedes mosquitoes, while hepatitis E virus (HEV) is a waterborne disease that is transmitted through the fecal-oral route. Both diseases have very close clinical presentation, namely fever, jaundice, malaise, and dark urine; they differ in severity and outcome. Methodology: In this cross-sectional, laboratory-based study, an attempt was made to measure the correlation of concomitant YF and HEV infection in Darfur States during the previous YF outbreak in 2012. Results: Results found concomitant outbreaks of YF and HEV at the same time with very weak statistical correlation between the two infections during the outbreak period, with Cramer's V correlation 0.05 and insignificant p value of 0.86. Conclusions: This correlation indicates that clinicians and care providers in tropical areas have to deal with clinical case definitions used for disease surveillance very carefully since prevalence of HEV infection is relatively common and this increases the possibility of misclassification and missing YF cases, particularly initial index cases, in a season or outbreak.

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Section: Discussionmentioning

confidence: 95%

Concomitant outbreaks of yellow fever and hepatitis E virus in Darfur States, Sudan, 2012

Ahmed

Soghaier

Mohammed

et al. 2016

J Infect Dev Ctries

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“…Both of these diseases were often always discussed separately. However, leptospirosis and dengue coinfection is an extremely rare event, with only five cases previously [6][7][8][9] reported in the English medical literature.…”

Section: Introductionmentioning

confidence: 99%

Coinfection of leptospirosis and dengue fever at a tertiary care center in South India

2012

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Introduction: Leptospirosis is a zoonosis with a worldwide distribution affecting almost 160 mammalian species. Dengue, one of the major mosquito-borne arboviral infections of humans is caused by any of the four serologically related viruses designated as DENV-1, DENV-2, DENV-3, and DENV-4. In the presentation of these two diseases, there exists similarity, which may result in the possibility of coinfection. The present study is carried out to confirm our hypothesis. Materials and Methods: The samples which were received from the clinically suspected cases of leptospirosis and dengue for a period of 3 years. All others with definitive alternate diagnosis were not included for the study. Samples were tested for immunoglobulin M (IgM) antibodies using Serion-virion (virion\Serion classic; Institut Virion Serion GmbH, Warburg, Germany) and PanBio IgM antibody-capture (MAC) ELISA (PanBio Inc., Brisbane, Australia) kit as per the instructions provided and the results were interpreted according to the manufacturer. Discussion and Results: In present study, there were 21.41% cases of leptospirosis, 11.2% cases of dengue fever, and 3.6% of cases were co infective. Conclusion:The present study emphasizes that in fewer cases; there may be a possibility of coinfection with leptospirosis and dengue. Therefore, high index of clinical suspicion is required so as to constitute appropriate therapy to reduce the mortality rate.

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“…Extensive literature search revealed that only two such case of co-infection is reported so far. [12] Both the previous cases survived but our case died. We are reporting our case along with review and comparison of these three cases.…”

Section: Introductionmentioning

confidence: 62%

“…[1] Here we report a case where we detected dengue, leptospirosis and hepatitis E virus (HEV) triple co-infection. Extensive literature search revealed that only two such case of co-infection is reported so far.…”

Section: Introductionmentioning

confidence: 99%

Comparison between three rare cases of co-infection with dengue, leptospira and hepatitis E: Is early endothelial involvement the culprit in mortality?

Singh

Ghatak

Saigal

et al. 2014

Ann Med Health Sci Res

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Co-infection in immunocompetent patients is rare. Though co-infection with dengue and leptospira cases is increasingly reported, a co-infection of this combination along with hepatitis E is rarely thought of. Until date only two case of triple co-infection have been reported world-wide. Here, we are reporting a patient with co-infection of dengue, leptospirosis and hepatitis E admitted to our intensive care unit. Early septic shock and increasing procalcitonin in dengue patient raised suspicion of co-infection. Our aim is to educate intensivists about this rare co-infection and hence that timely initiation of appropriate diagnostic, therapeutic and supportive measures can alter outcome favorably.

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Co-infections due to leptospira, dengue and hepatitis E: a diagnostic challenge

Cited by 35 publications

References 10 publications

Concomitant outbreaks of yellow fever and hepatitis E virus in Darfur States, Sudan, 2012

Concomitant outbreaks of yellow fever and hepatitis E virus in Darfur States, Sudan, 2012

Coinfection of leptospirosis and dengue fever at a tertiary care center in South India

Comparison between three rare cases of co-infection with dengue, leptospira and hepatitis E: Is early endothelial involvement the culprit in mortality?

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