This paper compares the forecasting ability of five alternative models in predicting four key macroeconomic variables, namely, per capita growth rate, the Consumer Price Index (CPI) inflation, the money market rate, and the growth rate of the nominal effective exchange rate for the South African economy. Unlike the theoretical Small Open Economy New Keynesian Dynamic Stochastic General Equilibrium (SOENKDSGE), the unrestricted VAR, and the small-scale Bayesian Vector Autoregressive (BVAR) models, which are estimated based on four variables, the Dynamic Factor Model (DFM) and the large-scale BVAR models use information from a data-rich environment containing 266 macroeconomic time series observed over the period of 1983:01 to 2002:04. The results, based on Root Mean Square Errors (RMSEs), for one-to four-quarters-ahead out-of-sample forecasts over the horizon of 2003:01 to 2006:04, show that, except for the one-quarter-ahead forecast of the growth rate of the of nominal effective exchange rate, large-scale BVARs outperform the other four models consistently and, generally, significantly.Journal of Economic Literature Classification: C11, C13, C33, C53.