CO laser applications in surgery

Aleĭnikov, V S; Belyaev, V. P.; Devyatkov, N. D.; Mamedly, L.D.; Masychev, Victor I.; Sysoev, V. К.

doi:10.1016/0030-3992(84)90010-0

Cited by 7 publications

(1 citation statement)

References 3 publications

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“…However, clearly a certain portion of the radiation energy is absorbed by the macromolecules, and this absorption increases as the coherence length increases and cannot be determined from the results of measurements of the absorption spectra. In [19], it is recommended that we take into account the difference between the tissue penetration depths for coherent and incoherent radiation in laser therapy, and in [20] the not yet understood fact is noted that there is an appreciable increase in absorption of coherent radiation in protein solutions compared with absorption of incoherent radiation.…”

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Role of coherence in interaction of opticalradiation with macromolecules

et al. 2006

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Based on analysis of the properties of macromolecules in a coherent optical radiation field and taking into account experimentally established data on the specificity of the interaction between laser radiation and biomolecules (the dependence of the efficacy of the interaction on the coherence length, the presence of an effect in a region of the spectrum far away from the absorption band), we propose a mechanism for wave interaction of coherent optical radiation with macromolecules, and we construct a very simple mathematical model for such interaction. Using the mathematical model, we calculate the dependence of the vibrational energy of the macromolecule in a coherent radiation field on the coherence time and the intramolecular relaxation rate. We show that the increase in the vibrational energy of the macromolecules strongly depends on the radiation coherence length. When exposed to incoherent radiation, the vibrational energy of the biomolecules remains practically constant, while when exposed to laser radiation (coherence length ≈3 cm), the vibrational energy of the atoms increases by 2-4 orders of magnitude, leading to a change in the conformation of the biomolecules and the activity of enzymes.Introduction. Low-intensity laser therapy (LLT) has been successfully used to treat a wide range of diseases. It is easier to name the types of diseases (such as, for example, malignancies and autoimmune diseases) where laser therapy is not yet widely used. Therapy methods for various diseases and their outcomes are described in a number of monographs [1-3] and in many methodological studies. In some countries, in particular Russia and Belarus, specialized centers for laser medicine have been created where laser therapy methods are under development and patients are being treated using such methods. In this case, unique results have been achieved using LLT to treat a wide range of serious diseases, such as trophic ulcers. Thus medical practice provides clear evidence for the occurrence of important effects when biological specimens are exposed to low-intensity laser radiation.Despite the impressive successes of laser therapy, the mechanism of action of laser radiation on biological specimens has remained unknown to date. This is the main reason for the lack of laser therapy methods guaranteeing a positive outcome in each specific case, rather than statistically, and so far there has been insufficient use of laser therapy in the countries of Western Europe and the United States.The clinical successes of LLT have proven to be so convincing that in 2002, the US Food and Drug Administration (FDA) approved the use of LLT to treat some dermatological diseases, although in this case the inadequate scientific understanding of the mechanism for the therapeutic effect of this physical factor was noted.The mechanism for interaction between low-intensity laser radiation and biological specimens can be arbitrarily divided into two stages: the primary event, associated with interaction of the radiation with the "target", the accep...

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confidence: 99%