Co-localisation of Glandular and Squamous Cell Markers in Non-small Cell Lung Cancer

Koyi, Hirsh; Brandén, Eva; Kasim, Ihsan; Wilander, Erik

doi:10.21873/anticanres.12600

Cited by 1 publication

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“…10,11 Another confounding factor is the co-localization of squamous and glandular markers that can occur in a significant number of NSCLC, making a precise diagnosis extremely difficult. 12 In order to preserve material for further studies, a limited panel of antibodies is recommended. 13 Several studies suggest p40 and TTF-1 are sufficient to discriminate between SCC and ADC of the lung, resulting in a reduction of cases in the NSCLC NOS (not otherwise specified) diagnostic group.…”

Section: Introductionmentioning

confidence: 99%

<p>A comparison of diagnostic panels in the immunohistochemical analysis of lung cancer</p>

Prabhakaran¹,

Xing

Hocking³

et al. 2019

PLMI

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Point your SmartPhone at the code above. If you have a QR code reader the video abstract will appear. Or use: https://youtu.be/JUgBeBu__LM Purpose: Classification of non-small cell lung carcinoma (NSCLC), as adenocarcinoma or squamous cell carcinoma, is important both in the diagnosis and treatment of lung cancer. Use of appropriate markers for this identification is crucial in order to conserve patient tissue for further molecular testing that could guide treatment decisions and have prognostic implications. Patients and methods: We constructed tissue microarrays from archival resections of 200 NSCLC that were previously subtyped based on morphology and immunohistochemistry (IHC) in some cases. We performed IHC with three TTF-1 clones (SP141, SPT24 and 8G7G3/1), Napsin A, p40, p63 and CK5/6 and panels of four or two markers that best help identify adenocarcinoma and squamous cell carcinoma were ascertained. Results: Our results showed that the best four-marker panel utilized TTF-1 (clone SP141), Napsin A, p63 and CK5/6 with a sensitivity of 98.3% and high specificity of 91.7%. The best twomarker panel was TTF-1 (clone SP141) and p63 with 96.5% sensitivity and 85.71% specificity. Conclusion: As there are variations in the performance of different clones of TTF-1 IHC antibodies, the clone chosen can increase the diagnostic value in differentiating adenocarcinoma from squamous cell carcinoma. In the panels analyzed, the survival of cases concordant with the diagnosis had longer survival compared to those that were discordant. The difference was however not statistically significant (p>0.05).

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Section: Introductionmentioning

confidence: 99%

<p>A comparison of diagnostic panels in the immunohistochemical analysis of lung cancer</p>

Prabhakaran¹,

Xing

Hocking³

et al. 2019

PLMI

View full text Add to dashboard Cite

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Co-localisation of Glandular and Squamous Cell Markers in Non-small Cell Lung Cancer

Abstract: Co-localisation of squamous and adenocarcinoma markers in the same tumour cell suggests that additional analyses for novel biomarkers of specific lung cancer types may subsequently lead to a refined treatment choice for patients with the goal of improving clinical outcomes.

Cited by 1 publication

References 24 publications

<p>A comparison of diagnostic panels in the immunohistochemical analysis of lung cancer</p>

<p>A comparison of diagnostic panels in the immunohistochemical analysis of lung cancer</p>

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