Co-nanoencapsulation of magnetic nanoparticles and selol for breast tumor treatment: in vitro evaluation of cytotoxicity and magnetohyperthermia efficacy

Estevanato, Luciana Landim Carneiro; Silva, Jaqueline da; Falqueiro, A. M.; Mosiniewicz-Szablewska, E.; Suchocki, Piotr; Tedesco, Antônio Cláudio; Morais, P.C.; Lacava, Zulmira G M

doi:10.2147/ijn.s35279

Cited by 15 publications

(3 citation statements)

References 30 publications

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“…However, inorganic selenite is poorly selective for cancer cells and thus presents severe systemic toxicity, limiting its clinical application. Selol is a mixture of selenitetriacylglycerides that has low cumulative toxicity [8,9], whereas its anticancer activity has been associated with the production of oxygen reactive species, which eventually leads to irreversible cell damage, cell cycle arrest, and the sensitization of multidrug-resistant cells [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Antitumor activity and systemic effects of PVM/MA-shelled selol nanocapsules in lung adenocarcinoma-bearing mice

Souza¹,

Muehlmann²,

Matos³

et al. 2015

Nanotechnology

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Selol is a semi-synthetic compound containing selenite that is effective against cancerous cells and safer for clinical applications in comparison with other inorganic forms of selenite. Recently, we have developed a formulation of poly(methyl vinyl ether-co-maleic anhydride)-shelled selol nanocapsules (SPN), which reduced the proliferative activity of lung adenocarcinoma cells and presented little deleterious effects on normal cells in in vitro studies. In this study, we report on the antitumor activity and systemic effects induced by this formulation in chemically induced lung adenocarcinoma-bearing mice. The in vivo antitumor activity of the SPN was verified by macroscopic quantification, immunohistochemistry and morphological analyses. Toxicity analyses were performed by evaluations of the kidney, liver, and spleen; analyses of hemogram and plasma levels of alanine aminotransferase, aspartate transaminase, urea, and creatinine; and DNA fragmentation and cell cycle activity of the bone marrow cells. Furthermore, we investigated the potential of the SPN formulation to cause hemolysis, activate the complement system, provoke an inflammatory response and change the conformation of the plasma proteins. Our results showed that the SPN reduced the area of the surface tumor nodules but not the total number of tumor nodules. The biochemical and hematological findings were suggestive of the low systemic toxicity of the SPN formulation. The surface properties of the selol nanocapsules point to characteristics that are consistent with the treatment of the tumors in vivo: low hemolytic activity, weak inflammatory reaction with no activation of the complement system, and mild or absent conformational changes of the plasma proteins. In conclusion, this report suggests that the SPN formulation investigated herein exhibits anti-tumoral effects against lung adenocarcinoma in vivo and is associated with low systemic toxicity and high biocompatibility.

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Section: Introductionmentioning

confidence: 99%

Antitumor activity and systemic effects of PVM/MA-shelled selol nanocapsules in lung adenocarcinoma-bearing mice

Souza¹,

Muehlmann²,

Matos³

et al. 2015

Nanotechnology

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“…In the other study, the effect of PLGA nanocapsules loaded with MNPs and selol treatment on the viability of the MCF-7 cell lines was tested with or without subsequent exposure to the external alternating magnetic field (AMF). The results showed that the presence of AMF caused a 50% decrease in cell viability [ 37 ]. Wang et al investigated the antitumor effect of a nanoparticle-based delivery system containing cross-linked hyaluronic acid and a low dose of DOX (X-NP-DOX) in both in vitro and in vivo conditions.…”

Section: Discussionmentioning

confidence: 99%

Magnetic Particles with Polymeric Shells Bearing Cholesterol Moieties Sensitize Breast Cancer Cells to Low Doses of Doxorubicin

Markiewicz

Niemirowicz-Laskowska

Szymczuk

et al. 2021

IJMS

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One of the promising strategies for improvement of cancer treatment is application of a combination therapy. The aim of this study was to investigate the anticancer activity of nanoformulations containing doxorubicin and iron oxide particles covered with polymeric shells bearing cholesterol moieties. It was postulated that due to high affinity to cell membranes, particles comprising poly(cholesteryl acrylate) can sensitize cancer cells to doxorubicin chemotherapy. The performed analyses revealed that the developed systems are effective against the human breast cancer cell lines MCF-7 and MDA-MB-231 even at low doses of the active compound applied (0.5 µM). Additionally, high compatibility and lack of toxicity of the tested materials against human red blood cells, immune (monocytic THP-1) cells, and cardiomyocyte H9C2(2-1) cells was demonstrated. Synergistic effects observed upon administration of doxorubicin with polymer–iron oxide hybrids comprising poly(cholesteryl acrylate) may provide an opportunity to limit toxicity of the drug and to improve its therapeutic efficiency at the same time.

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“…Trx also plays an important role in cell viability and in the regulation of apoptosis in vitro [ 47 , 48 ]. Inactivation of TrxR-1 in mouse embryos disturbs cell proliferation, causing retardation of neural tube closure and consequently their death in utero [ 45 , 49 ]. Likewise, a mitochondrial redox protein Trx-2 is required for proper embryonic development and it is necessary for actively respiring cells.…”

Section: Selenium and Selenoproteins In Normal Brain Functionmentioning

confidence: 99%

Selenium in the Therapy of Neurological Diseases. Where is it Going?

Dominiak¹,

Wilkaniec

Wroczyński³

et al. 2016

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Selenium (34Se), an antioxidant trace element, is an important regulator of brain function. These beneficial properties that Se possesses are attributed to its ability to be incorporated into selenoproteins as an amino acid. Several selenoproteins are expressed in the brain, in which some of them, e.g. glutathione peroxidases (GPxs), thioredoxin reductases (TrxRs) or selenoprotein P (SelP), are strongly involved in antioxidant defence and in maintaining intercellular reducing conditions. Since increased oxidative stress has been implicated in neurological disorders, including Parkinson’s disease, Alzheimer’s disease, stroke, epilepsy and others, a growing body of evidence suggests that Se depletion followed by decreased activity of Se-dependent enzymes may be important factors connected with those pathologies. Undoubtedly, the remarkable progress that has been made in understanding the biological function of Se in the brain has opened up new potential possibilities for the treatment of neurological diseases by using Se as a potential drug. However, further research in the search for optimal Se donors is necessary in order to achieve an effective and safe therapeutic income.

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Co-nanoencapsulation of magnetic nanoparticles and selol for breast tumor treatment: in vitro evaluation of cytotoxicity and magnetohyperthermia efficacy

Cited by 15 publications

References 30 publications

Antitumor activity and systemic effects of PVM/MA-shelled selol nanocapsules in lung adenocarcinoma-bearing mice

Antitumor activity and systemic effects of PVM/MA-shelled selol nanocapsules in lung adenocarcinoma-bearing mice

Magnetic Particles with Polymeric Shells Bearing Cholesterol Moieties Sensitize Breast Cancer Cells to Low Doses of Doxorubicin

Selenium in the Therapy of Neurological Diseases. Where is it Going?

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