Co-Nanoencapsulation of Vitamin D3 and Curcumin Regulates Inflammation and Purine Metabolism in a Model of Arthritis

Silva, Jean Lucas G da; Passos, Daniela F.; Bernardes, Viviane M.; Cabral, Fernanda Licker; Schimites, Paulo G; Manzoni, Alessandra Guedes; Oliveira, Edilene Gadelha de; Silva, Cristiane de Bona da; Beck, Ruy Carlos Ruver; Jantsch, Matheus Henrique; Maciel, Roberto Marinho

doi:10.1007/s10753-019-01021-1

Cited by 20 publications

(13 citation statements)

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“…66 Curcumin at the dose of 25 mg/kg, significantly reduced plasma myeloperoxidase and adenosine deaminase activity. 52 However, Khayyal et al 63 did not detect a significant decrease in serum myeloperoxidase. Two papers assessed the effects of curcumin on oxidative stress in animal models of RA.…”

Section: Curcumin Effect On Antioxidant and Peroxidase Enzymes And Oxidative Stressmentioning

confidence: 95%

“…(n = 6) 57,68,69,72,75,78 ; and Balb/c (n = 1) 58 ) or rats (Wistar (n = 1 9) 47,49,51,52,53,54,55,56,60,62,63,64,65,66,67,70,71,82,83 ; Sprague-Dawley (n = 9) 48,50,61,74,76,77,79,80,81 ; Charles Foster (n = 1) 73 and in one study there was no information about the kind of rats 59 ). The induction of RA was performed by injection of complete Freund's adjuvant (CFA) (n = 19), 47,48,49,50,51,52,54,55,63,64,65,66,67,70,73,…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Yoshikawa et al 78 showed that curcumin significantly decreased the arthritis score. Silva et al 52 showed that curcumin at the dose of 25 mg/ kg, significantly reduced the edema formation, thermal hyperalgesia and arthritis score. Treatment with 110 mg/kg curcumin significantly reduced the arthritis score and bone erosion in the arthritic joints 61,79 and also cell infiltration into the synovial tissue.…”

Section: Curcumin Effect On Radiographic Scorementioning

confidence: 99%

“…Arora et al 47 found that curcumin at the dose of 30 mg/kg significantly decreased the serum levels of malondialdehyde and nitrite. Silva et al 52 demonstrated that the serum levels of reactive oxygen species (ROS) remained unchanged after the treatments.…”

Section: Curcumin Effect On Antioxidant and Peroxidase Enzymes And Oxidative Stressmentioning

confidence: 99%

“…Curcumin in different doses significantly increased the body weight. 49,52,64,76 Alghadir et al 82 showed that oral with topical administration of curcumin significantly increased body weight.…”

Section: Curcumin Effect On Weight Gainmentioning

confidence: 99%

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Curcumin and rheumatoid arthritis: A systematic review of literature

2021

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Background: Curcumin is a natural polyphenol and the main compound from the rhizome of Turmeric (Curcuma longa) and other Curcuma species. It has been widely used for different medical purposes, such as improvement of pain and inflammatory conditions in various diseases.Purpose: This systematic review was aimed to assess all studies regarding the efficacy of the pure form of curcumin (unformulated curcumin) on rheumatoid arthritis (RA). Methods: The comprehensive search of the literature was done until September 2020 on the MEDLINE, Embase, Scopus and Web of Knowledge databases. Out of 2079 initial records, 51 articles (13 in vitro and 37 animal and one human) were met our inclusion criteria. Results: Most studies have shown the curative effects of curcumin on clinical and inflammatory parameters of RA and reported different mechanisms; inhibition of mitogen-activated protein kinase family, extracellular signal-regulated protein kinase, activator protein-1 and nuclear factor kappa B are the main mechanisms associated with the anti-inflammatory function of curcumin in RA. The results of the only human study showed that curcumin significantly improved morning stiffness, walking time and joint swelling. Conclusion:In conclusion, curcumin seems to be useful, and it is recommended that more human studies be performed to approve the cellular and animal results and determine the effective and optimal doses of curcumin on RA patients. Review criteria• The MEDLINE database (PubMed), Embase, Scopus, and Thomson Reuters Web of Knowledge were systematically and comprehensively searched until September 2020, using related keywords.• All English written original in vitro, animal, and human studies on the effects of curcumin on RA were included.

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Section: Curcumin Effect On Antioxidant and Peroxidase Enzymes And Oxidative Stressmentioning

confidence: 95%