Co-occurrence and distribution of deoxynivalenol, nivalenol and zearalenone in wheat from Brazil

Calori‐Domingues, Maria Antonia; Bernardi, Carolina Maria Gil; Nardin, Mariana Sartori; Souza, Gláucia Vendramini de; Santos, Fernanda Gregório Ribeiro Dos; Stein, Mirella de Abreu; Glória, Eduardo Micotti da; Dias, Carlos Tadeu dos Santos; Camargo, Adriano Costa de

doi:10.1080/19393210.2016.1152598

Cited by 60 publications

(35 citation statements)

References 35 publications

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“… 37 . The doses used in the present study (0.125, 0.5, 2 μM) is comparable to the circulating levels that could be achieved in animals, when considering that the average levels of NIV in maize and wheat samples for farm animals could reach 0.53, 1 and 15.28 mg/kg in Zimbabwe (in 2014) 2 , Brazil (in 2009) 1 and Hubei of China (in 2009) 39 , respectively. Besides, the natural exposure of animals to NIV was a long process, which make the animals more prone to be influenced by the toxin.…”

Section: Discussionsupporting

confidence: 53%

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Nitric oxide mediates apoptosis and mitochondrial dysfunction and plays a role in growth hormone deficiency by nivalenol in GH3 cells

Huang¹,

Cui²,

Guo³

et al. 2017

Sci Rep

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Nivalenol (NIV), a type B trichothecenes commonly found in cereal crops, can cause growth impairment in animals. However, limited information about its mechanisms is available. Trichothecenes have been characterized as an inhibitor of protein synthesis and induce apoptosis in cells. Oxidative stress is considered an underlying mechanism. However, whether NIV can induce oxidative stress and apoptosis in rat pituitary cells line GH3 is unclear. The present study showed that NIV significantly reduced the viability of cells and caused oxidative stress in GH3 cells. Further experiments showed that nitric oxide (NO), but not ROS, mediated NIV-induced oxidative stress. Additionally, NIV induced caspase-dependent apoptosis, decrease in mitochondrial membrane potential and mitochondrial ultrastructural changes. However, NIV-induced caspase activation, mitochondrial damage and apoptosis were partially alleviated by Z-VAD-FMK or NO scavenger hemoglobin. Finally, NIV changed the expression of growth-associated genes and pro-inflammatory cytokines. NIV also reduced the GH secretion in GH3 cells, which was reversed by hemoglobin. Taken together, these results suggested that NIV induced apoptosis in caspase-dependent mitochondrial pathway in GH3 cells, which might be an underlying mechanism of NIV-induced GH deficiency. Importantly, NO played a critical role in the induction of oxidative stress, apoptosis and GH deficiency in NIV-treated GH3 cells.

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Section: Discussionsupporting

confidence: 53%

“…Nivalenol (NIV), a type B trichothecenes mycotoxin, is commonly found as a contaminant in cereals like wheat, maize and barley 1 , 2 . In animals, NIV can induce a series of toxic actions including diarrhea, emesis, anemia and suppression of appetite 3 .…”

Section: Introductionmentioning

confidence: 99%

Nitric oxide mediates apoptosis and mitochondrial dysfunction and plays a role in growth hormone deficiency by nivalenol in GH3 cells

Huang¹,

Cui²,

Guo³

et al. 2017

Sci Rep

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“…Additionally, mycotoxins produced by different fungi are also among possible carcinogens. Mycotoxins may be found in different food products [158,159,160], including oilseeds, cereals, and milk; however, avoiding consumption of these products may or may not be a realistic option. DNA damage induced by different mycotoxins has been demonstrated in vitro and in vivo [127,161].…”

Section: Tocopherols and Tocotrienols In Health Promotionmentioning

confidence: 99%

Tocopherols and Tocotrienols in Common and Emerging Dietary Sources: Occurrence, Applications, and Health Benefits

Shahidi

Camargo

2016

IJMS

331

182

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Edible oils are the major natural dietary sources of tocopherols and tocotrienols, collectively known as tocols. Plant foods with low lipid content usually have negligible quantities of tocols. However, seeds and other plant food processing by-products may serve as alternative sources of edible oils with considerable contents of tocopherols and tocotrienols. Tocopherols are among the most important lipid-soluble antioxidants in food as well as in human and animal tissues. Tocopherols are found in lipid-rich regions of cells (e.g., mitochondrial membranes), fat depots, and lipoproteins such as low-density lipoprotein cholesterol. Their health benefits may also be explained by regulation of gene expression, signal transduction, and modulation of cell functions. Potential health benefits of tocols include prevention of certain types of cancer, heart disease, and other chronic ailments. Although deficiencies of tocopherol are uncommon, a continuous intake from common and novel dietary sources of tocopherols and tocotrienols is advantageous. Thus, this contribution will focus on the relevant literature on common and emerging edible oils as a source of tocols. Potential application and health effects as well as the impact of new cultivars as sources of edible oils and their processing discards are presented. Future trends and drawbacks are also briefly covered.

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“…The antioxidant and potential beneficial effects of different sources of proanthocyanidins against human LDL-cholesterol oxidation and proliferation of breast cancer cells has already been reported [12,25,32]. Contamination with mycotoxins remains a concern for different food products such as milk, wheat and peanuts [33][34][35]. However, it is very difficult to avoid this kind of contamination; furthermore, avoidance from consuming this kind of food products is not always possible.…”

Section: Identification and Quantification Of Phenolic Compoundsmentioning

confidence: 99%

Phenolic Profile of Peanut By‐products: Antioxidant Potential and Inhibition of Alpha‐Glucosidase and Lipase Activities

Camargo

Regitano-D’Arce

Shahidi

2017

J Americ Oil Chem Soc

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Free, esterified, etherified and insolublebound phenolics from three samples, namely meal from whole peanuts (MWP), meal from dry-blanched peanuts (MDBP) and peanut skin (PS) were evaluated for their total phenolic content (TPC), and phenolic profile using HPLC-DAD-ESI-MS n . The TPC was in the order of PS > MWP > MDBP. Among 37 compounds identified 10 were reported for peanuts for the first time. Proanthocyanidins were detected in peanut skin and MWP, but not in MDBP. The presence of peanut skin in MWP rendered up to 9.8-fold higher scavenging activity towards the DPPH radical as compared with MDBP. Phenolics from all samples and fractions showed inhibition of alpha-glucosidase and lipase activities, which are key enzymes involved in the absorption of glucose and triacylglycerols, respectively. Therefore, their antioxidant properties as well as their potential role in the management of diabetes and obesity makes them worthy of further consideration as functional food ingredients.Electronic supplementary material The online version of this article (

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Co-occurrence and distribution of deoxynivalenol, nivalenol and zearalenone in wheat from Brazil

Cited by 60 publications

References 35 publications

Nitric oxide mediates apoptosis and mitochondrial dysfunction and plays a role in growth hormone deficiency by nivalenol in GH3 cells

Nitric oxide mediates apoptosis and mitochondrial dysfunction and plays a role in growth hormone deficiency by nivalenol in GH3 cells

Tocopherols and Tocotrienols in Common and Emerging Dietary Sources: Occurrence, Applications, and Health Benefits

Phenolic Profile of Peanut By‐products: Antioxidant Potential and Inhibition of Alpha‐Glucosidase and Lipase Activities

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