Co-occurrence of aflatoxin B<sub>1</sub>, fumonisin B<sub>1</sub>, ochratoxin A and zearalenone in cereals and peanuts from Côte d’Ivoire

Sangare-Tigori, Béatrice; Moukha, Serge; Kouadio, H. James; Betbeder, A. M.; Dano, Djédjé Sébastien; Creppy, Edmond E.

doi:10.1080/02652030500415686

Cited by 130 publications

(77 citation statements)

References 22 publications

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“…Could OTA tested at non cytotoxic level decrease also AFB 1 induced -cytotoxic effect? In this study, we attempted to provide adequate response to this question insofar as numerous surveys carried out on presence of mycotoxins in foods from Côte d'Ivoire revealed high concentrations of AFB 1 but low concentrations of OTA [21,22].…”

Section: Discussionmentioning

confidence: 99%

“…Human population is probably exposed to multiple mycotoxins because human diet is generally varied and because the same food might be contaminated by several mycotoxins [20,21]. For example, studies focused on mycotoxins presence in foods from Côte d'Ivoire reported co-occurrence of aflatoxin B 1 , ochratoxin A, fumonisin and zearalenone in rice, maize, peanuts [21].…”

Section: Introductionmentioning

confidence: 99%

“…For example, studies focused on mycotoxins presence in foods from Côte d'Ivoire reported co-occurrence of aflatoxin B 1 , ochratoxin A, fumonisin and zearalenone in rice, maize, peanuts [21]. Since, multi-exposure could lead to additive, synergistic or antagonistic effects [5,7,15,16], several combinations of mycotxins such as binary or tertiary combination were tested on cells line in the aim to observe their simultaneous effect on cellular damages namely cytotoxicty, genotoxicity, or cells metabolism [5,7,15,16] but very few had concerned the mixture of AFB 1 and OTA [15,16].…”

Section: Introductionmentioning

confidence: 99%

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Low level of Ochratoxin A enhances Aflatoxin B1 Induced Cytotoxicity and Lipid Peroxydation in Both Human Intestinal (Caco-2) and Hepatoma (HepG2) Cells Lines

Halbin¹,

Brou²,

Dago³

2013

IJNFS

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Abstract:Aflatoxin B 1 (AFB 1 ) and ochratoxin A (OTA) are contaminants which co-occurred in the same food such as cereals. The few studies performed on their interactive effect had revealed additive or antagonistic cytotoxic effect according to cells endpoints and concentrations of both mycotoxins. The aim of the present study was to investigate in a possible influence of very low level of ochratoxin A in aflatoxin B 1 toxic action regarding cellular endpoints such as malonedialdehyde (MDA) production and cells viability as evaluated by lysosome and mitochondria integrities and cell lactate dehydrogenase (LDH) leakage. OTA (20nM) and AFB 1 were tested in combination in both human intestinal (Caco-2) and hepatoma (HepG2) cells lines. As results, OTA alone tested at 20nM was not cytotoxic and did not induce MDA production in both Caco-2 and HepG2 cells line. Interestingly, combined to AFB 1 (10µM), OTA enhanced markedly AFB 1 cytotoxic effect. OTA significantly increased cell lysosomes damage induced by AFB 1 from 24% to 38% (+14%) and from 28% to 43% (+15%) respectively in Caco-2 and HepG2 cells line (p<0.05). Similarly, OTA enhanced inhibition of mitochondria succinate dehydrogenase activity induced by AFB 1 until to +15% and +6% respectively in Caco-2 and HepG2 cells line (p<0.05). On cell necrosis marker, the mixture of OTA and AFB 1 induced more LDH leakage when compared to AFB 1 alone with increase of +14% and +12% respectively in Caco-2 and HepG2 cells line (p<0.05). Finally, on MDA production, AFB 1 + OTA induced more intensively MDA production when compared to AFB 1 alone with +49% and +110% of increasing in both Caco-2 and HepG2 cells line (p<0.01). Taken together, our results suggested that combined AFB 1 and OTA induced all the toxicities observed with the mycotoxins separately but more intensively suggesting synergistic or potentiating effect. Moreover, AFB 1 or its association with OTA had been found very potent in human hepatic cells HepG2 in necrosis induction but especially in lipids oxidative damage confirming oxidative stress as one of keys pathways in toxic action of AFB 1 .

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Low level of Ochratoxin A enhances Aflatoxin B1 Induced Cytotoxicity and Lipid Peroxydation in Both Human Intestinal (Caco-2) and Hepatoma (HepG2) Cells Lines

Halbin¹,

Brou²,

Dago³

2013

IJNFS

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“…The fungal and aflatoxins contamination was reported in rice in Turkey (Aydin et al, 2010); in maize from south-western Nigeria (Bankole & Mabekoje, 2004), Brazil (Rocha et al, 2009) and northern Italy (Pietri et al, 2004); in domestic and imported beers in Canada (Mably et al, 2005); and in peanuts in the Cote d'Ivoire (Sangare-Tigori et al, 2006), between others. Since contamination of grains with mycotoxins is not efficiently eliminated by most of the food processing operations such as sorting, trimming, cleaning, milling, brewing, cooking, baking, frying, roasting, canning, flaking, alkaline cooking, nixtamalization, and extrusion; the fungal toxins are commonly found in grain by-products.…”

Section: Approaches In the Articles Regarding To Foodsmentioning

confidence: 99%

The Evolutionary Dynamics in the Research on Aflatoxins During the 2001-2010 Decade

Theumer¹,

Rubinstein²

2011

Aflatoxins - Biochemistry and Molecular Biology

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“…OTA is a common contaminant of cereals, dried fruits, coffee and cocoa, as well as manufactured food products such as chocolate, wine, beer, and bread (Miraglia and Brera, 2002;Sangare et al, 2006). OTA-contaminated foods may be pathogenic to humans and animals (Rutqvist et al, 1978).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Ochratoxin A intake due to consumption of coffee and cocoa derivatives marketed in Abidjan (Cte dIvoire)

Manda¹,

Adepo²,

NgbÃ³

et al. 2016

J. Toxicol. Environ. Health Sci.

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Ochratoxin A is a mycotoxin produced by moulds belonging to the Aspergillus and Penicillium species, and is a common contaminant of various food products. Ochratoxin A is known for its nephrotoxic and carcinogenic effects; protective actions to protect consumer health must be established. The aim of this study was to assess the level of contamination of manufactured coffee and cocoa-based products marketed in Abidjan to estimate ochratoxin A intake related to the consumption of these goods. We quantified ochratoxin A in 87 samples by high-performance liquid chromatography with fluorescence detection. Coffee samples contained an average of 4.0 ± 3.4 µg/kg ochratoxin A and cocoa-based industrial products 0.9 ± 0.6 µg/kg. OTA intakes were assessed using data obtained from the analysis and the estimated Ivorian adult daily consumptions. The average estimated intake for the Ivorian population is 0.15 ng/kg bw/d for coffee and 0.02 ng/kg bw/d for cocoa, lower than the tolerable daily intakes of 5 and 14 ng/kg bw/d, respectively set by the European Commission and World Health Organization. However, in view of the toxicity of OTA, it is imperative to establish legislation on mycotoxin in Côte d'Ivoire

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Co-occurrence of aflatoxin B₁, fumonisin B₁, ochratoxin A and zearalenone in cereals and peanuts from Côte d’Ivoire

Cited by 130 publications

References 22 publications

Low level of Ochratoxin A enhances Aflatoxin B1 Induced Cytotoxicity and Lipid Peroxydation in Both Human Intestinal (Caco-2) and Hepatoma (HepG2) Cells Lines

Low level of Ochratoxin A enhances Aflatoxin B1 Induced Cytotoxicity and Lipid Peroxydation in Both Human Intestinal (Caco-2) and Hepatoma (HepG2) Cells Lines

The Evolutionary Dynamics in the Research on Aflatoxins During the 2001-2010 Decade

Assessment of Ochratoxin A intake due to consumption of coffee and cocoa derivatives marketed in Abidjan (Cte dIvoire)

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Co-occurrence of aflatoxin B1, fumonisin B1, ochratoxin A and zearalenone in cereals and peanuts from Côte d’Ivoire

Cited by 130 publications

References 22 publications

Low level of Ochratoxin A enhances Aflatoxin B1 Induced Cytotoxicity and Lipid Peroxydation in Both Human Intestinal (Caco-2) and Hepatoma (HepG2) Cells Lines

Low level of Ochratoxin A enhances Aflatoxin B1 Induced Cytotoxicity and Lipid Peroxydation in Both Human Intestinal (Caco-2) and Hepatoma (HepG2) Cells Lines

The Evolutionary Dynamics in the Research on Aflatoxins During the 2001-2010 Decade

Assessment of Ochratoxin A intake due to consumption of coffee and cocoa derivatives marketed in Abidjan (Cte dIvoire)

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Product

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Co-occurrence of aflatoxin B₁, fumonisin B₁, ochratoxin A and zearalenone in cereals and peanuts from Côte d’Ivoire