Co-occurrence of AIDS and Tuberculosis: Results of a Database"Match" and Investigation

Gollub, Erica L.; Trino, Ruth; Salmon, Melinda E.; Moore, Len; Dean, James L.; Davidson, Bruce L.

doi:10.1097/00042560-199709010-00007

Cited by 7 publications

(5 citation statements)

References 7 publications

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“…In addition, lower utilization of health services, poor treatment compliance and low completion rates among drug users may lead to more severe or prolonged tuberculosis, and more transmission in this group [ 2 , 10 , 11 ]. However, IDU by itself may be an independent risk factor for active tuberculosis [ 6 – 8 , 12 ]. Studies examining the association of IDU with LTBI have yielded mixed results [ 13 – 15 ].…”

Section: Introductionmentioning

confidence: 99%

Active and latent tuberculosis among HIV‐positive injecting drug users in Indonesia

Meijerink

Wisaksana

Lestari

et al. 2015

Journal of the International AIDS Society

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IntroductionInjecting drug use (IDU) is associated with tuberculosis but few data are available from low-income settings. We examined IDU in relation to active and latent tuberculosis (LTBI) among HIV-positive individuals in Indonesia, which has a high burden of tuberculosis and a rapidly growing HIV epidemic strongly driven by IDU.MethodsActive tuberculosis was measured prospectively among 1900 consecutive antiretroviral treatment (ART)-naïve adult patients entering care in a clinic in West Java. Prevalence of LTBI was determined cross-sectionally in a subset of 518 ART-experienced patients using an interferon-gamma release assay.ResultsPatients with a history of IDU (53.1%) more often reported a history of tuberculosis treatment (34.8% vs. 21.9%, p<0.001), more often received tuberculosis treatment during follow-up (adjusted HR=1.71; 95% CI: 1.25–2.35) and more often had bacteriologically confirmed tuberculosis (OR=1.67; 95% CI: 0.94–2.96). LTBI was equally prevalent among people with and without a history of IDU (29.1 vs. 30.4%, NS). The risk estimates did not change after adjustment for CD4 cell count or ART.ConclusionsHIV-positive individuals with a history of IDU in Indonesia have more active tuberculosis, with similar rates of LTBI. Within the HIV clinic, LTBI screening and isoniazid preventive therapy may be prioritized to patients with a history of IDU.

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Section: Introductionmentioning

confidence: 99%

Active and latent tuberculosis among HIV‐positive injecting drug users in Indonesia

Meijerink

Wisaksana

Lestari

et al. 2015

Journal of the International AIDS Society

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“…Previous studies have shown that HIV+ patients have an increased risk of TB infection (Havlir and Barnes, 1999;Colebunders and Lambert, 2002). The cellular immunosuppression induced by HIV infection prepares the entry of Mycobacterium tuberculosis and is a factor of TB recrudescence (Gollub et al, 1997 infected subjects are 20 to 30 times more likely to develop active TB than HIV-negative subjects (WHO, 2018). Also, the obtained prevalence value of TB-HIV coinfection was slightly high among men (15.18%) compared to women (14.28%), more common in the 21 to 49 age group, representing 82.82% of co-infected cases, and also more prevalent among singles and married people as well, with 88.88% of co-infected cases.…”

Section: Discussionmentioning

confidence: 99%

Liver enzyme evaluation and NAT2 polymorphism in patients on anti-tuberculosis and antiretroviral drugs at Jamot Hospital in Yaound-Cameroon

Ambassa,

Tiani,

Djuidje

et al. 2022

Afr. J. Biotechnol.

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Hepatotoxicity is reported frequently as an adverse reaction during tuberculosis (TB) and HIV treatment. This study aimed to investigate the incidence of antiretroviral and anti-tuberculosis druginduced liver enzymes activities variation in TB and TB-HIV co-infected patients at Jamot Hospital in Yaoundé-Cameroon. From April 2018 to May 2019, 336 treatment-naïve TB patients were enrolled. Liver enzymes (AST, ALT, ALP) and total bilirubin were evaluated at baseline and 12 weeks after treatment initiation. Blood was spotted on filter paper for DNA extraction by the chelex method. Standard nested PCR followed by restriction enzyme analysis with KpnI, TaqI, and BamHI to detect NAT2 polymorphisms was performed. TB-HIV co-infection prevalence was 29.46%. There was a significant rise of transaminases (p < 0.05) at baseline in TB-HIV co-infected patients. At 12 weeks, there was a substantial rise of transaminases in TB patients, and total bilirubin in TB-HIV co-infected patients (p < 0.05). The prevalence of slow and fast acetylators was 85.71 and 14.29%, respectively. NAT2*5/5 and NAT2*5/6 genotypes were most represented. Slow acetylating NAT2 phenotype was significantly associated with drug hepatotoxicity (p < 0.05). The prevalence of TB-HIV co-infections remains high, and the rise in transaminases is linked to the slow acetylating NAT2 phenotype.

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“…19 Thus, linking the AIDS and TB registry data becomes a very important tool to identify AIDS/TB cases, and has been widely used by the state health departments in the United States since the mid 1980s. 16–22…”

Section: Discussionmentioning

confidence: 99%

“…To monitor the impact of HIV infection on the epidemiology of TB in a region, AIDS and TB registry data linkage had been widely used by state health departments in the United States. 16–22 However, all studies used a deterministic method without reporting its sensitivity and positive predictive value (PPV). A deterministic method uses a combination of algorithms and rules to look for exact agreement on one or more matching variables between data files with the capability to catch some common errors such as typos, phonetic variations, and transpositions.…”

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confidence: 99%

Matching AIDS and tuberculosis registry data to identify AIDS/tuberculosis comorbidity cases in California

Xia

Westenhouse

Schultz

et al. 2011

Health Informatics J

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The purpose of this study was to evaluate the sensitivity and positive predictive value (PPV) of a registry data linkage procedure used in the California AIDS and Tuberculosis (TB) Registry Data Linkage Study to identify AIDS/TB comorbidity cases in California. The California AIDS registry data from 1981 to 2006 were linked to the California TB registry data from 1996 to 2006 using LinkPlus, a probabilistic record linkage program developed by the Centers for Disease Control and Prevention, and matched results were manually reviewed to determine true or false matches. We estimated the sensitivity of this procedure to range from 98.0 per cent (95% confidence interval, CI: 97.3%, 98.7%) to 98.8 per cent (95% CI: 98.1%, 99.2%), and the PPV to be 100 per cent (95% CI: 96.8%, 100.0%). Our study demonstrated the feasibility of using this linkage procedure to match AIDS and TB registry data with a very high degree of accuracy.

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Co-occurrence of AIDS and Tuberculosis: Results of a Database"Match" and Investigation

Cited by 7 publications

References 7 publications

Active and latent tuberculosis among HIV‐positive injecting drug users in Indonesia

Active and latent tuberculosis among HIV‐positive injecting drug users in Indonesia

Liver enzyme evaluation and NAT2 polymorphism in patients on anti-tuberculosis and antiretroviral drugs at Jamot Hospital in Yaound-Cameroon

Matching AIDS and tuberculosis registry data to identify AIDS/tuberculosis comorbidity cases in California

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