Co-occurrence of anxiety and depressive-like behaviors following adolescent social isolation in male mice; possible role of nitrergic system

Amiri, Shayan; Haj‐Mirzaian, Arya; Rahimi-Balaei, Maryam; Razmi, Ali; Kordjazy, Nastaran; Shirzadian, Armin; Mehr, Shahram Ejtemaei; Sianati, Hamed; Dehpour, Ahmad Reza

doi:10.1016/j.physbeh.2015.03.032

Cited by 108 publications

(72 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Individual housing conditions are capable of eliciting behavioral and/or neurochemical changes (Brain, 1975; Goldsmith et al, 1978; Hilakivi et al, 1989), particularly in adolescent animals (Robbins et al, 1996; Weintraub et al, 2010; Amiri et al, 2015). Although individual housing could be a potential confounding factor for our results, other researchers have demonstrated that elevated alcohol consumption and resilience to withdrawal-induced anxiety in adolescent animals is not a function of isolation stress/individual housing (Brunell and Spear, 2005).…”

Section: Discussionmentioning

confidence: 99%

Adolescent Mice Are Resilient to Alcohol Withdrawal-Induced Anxiety and Changes in Indices of Glutamate Function within the Nucleus Accumbens

Lee

Coelho

McGregor

et al. 2016

Front. Cell. Neurosci.

124

View full text Add to dashboard Cite

Binge-drinking is the most prevalent form of alcohol abuse and while an early life history of binge-drinking is a significant risk factor for subsequent alcoholism and co-morbid affective disorders, relatively little is known regarding the biobehavioral impact of binge-drinking during the sensitive neurodevelopmental period of adolescence. In adult mice, a month-long history of binge-drinking elicits a hyper-glutamatergic state within the nucleus accumbens (Acb), coinciding with hyper-anxiety. Herein, we employed a murine model of binge-drinking to determine whether or not: (1) withdrawal-induced changes in brain and behavior differ between adult and adolescent bingers; and (2) increased behavioral signs of negative affect and changes in Acb expression of glutamate-related proteins would be apparent in adult mice with less chronic binge-drinking experience (14 days, approximating the duration of mouse adolescence). Adult and adolescent male C57BL/6J mice were subjected to a 14-day binge-drinking protocol (5, 10, 20 and 40% alcohol (v/v) for 2 h/day), while age-matched controls received water. At 24 h withdrawal, half of the animals from each group were assayed for negative affect, while tissue was sampled from the shell (AcbSh) and core (AcbC) subregions of the remaining mice for immunoblotting analyses. Adult bingers exhibited hyper-anxiety when tested for defensive marble burying. Additionally, adult bingers showed increased mGlu1, mGlu5, and GluN2b expression in the AcbSh and PKCε and CAMKII in the AcbC. Compared to adults, adolescent mice exhibited higher alcohol intake and blood alcohol concentrations (BACs); however, adolescent bingers did not show increased anxiety in the marble-burying test. Furthermore, adolescent bingers also failed to exhibit the same alcohol-induced changes in mGlu and kinase protein expression seen in the adult bingers. Irrespective of age, bingers exhibited behavioral hyperactivity in the forced swim test (FST) compared to water drinkers, which was paralleled by an increase in AcbC levels of GluN2b. Thus, a 2-week period of binge-drinking is sufficient to produce a hyper-anxious state and related increases in protein indices of Acb glutamate function. In contrast, adolescents were resilient to many of the effects of early alcohol withdrawal and this attenuated sensitivity to the negative consequences of binge drinking may facilitate greater alcohol intake in adolescent drinkers.

show abstract

Section: Discussionmentioning

confidence: 99%

Adolescent Mice Are Resilient to Alcohol Withdrawal-Induced Anxiety and Changes in Indices of Glutamate Function within the Nucleus Accumbens

Lee

Coelho

McGregor

et al. 2016

Front. Cell. Neurosci.

124

View full text Add to dashboard Cite

show abstract

“…Therefore, mice are often single housed, which has also been shown to increase aggression [see for example Crawley et al, ]. On the other hand, social isolation has also been connected to depressive behaviors in mice [see for example Amiri et al, ] and thus might not be perfectly suited for assessment of aggressive tendencies. Therefore, several studies have attempted to group house mice while maintaining high levels of aggression, including group housing with a female [see for example Newman et al, ] or even group housing with the intruder mouse up to one day before testing [Bolivar et al, ].…”

Section: Introductionmentioning

confidence: 99%

Aggression in non‐human vertebrates: Genetic mechanisms and molecular pathways

Freudenberg

Gutiérrez

Post

et al. 2015

American J of Med Genetics Pt B

View full text Add to dashboard Cite

Aggression is an adaptive behavioral trait that is important for the establishment of social hierarchies and competition for mating partners, food, and territories. While a certain level of aggression can be beneficial for the survival of an individual or species, abnormal aggression levels can be detrimental. Abnormal aggression is commonly found in human patients with psychiatric disorders. The predisposition to aggression is influenced by a combination of environmental and genetic factors and a large number of genes have been associated with aggression in both human and animal studies. In this review, we compare and contrast aggression studies in zebrafish and mouse. We present gene ontology and pathway analyses of genes linked to aggression and discuss the molecular pathways that underpin agonistic behavior in these species.

show abstract

“…В результате социальной изоляции в онтоге-незе у грызунов развивается описанный нами выше «синдром социальной изоляции» [14], который вы-ражается в повышении реактивности подкрепляю-щих систем мозга, гиперактивности и повышенной агрессивности в сочетании с высоким уровнем де-прессивности [12,14]. Социальная изоляция дете-нышей от матери и сородичей-сверстников при-водит также к таким поведенческим изменениям, как уменьшение престимульного старт-рефлекса вздрагивания в ответ на звуковой сигнал [32], к уве-личению уровня тревожности [27], агрессивности [21] и двигательной активности [16], нарушению процессов обучения и памяти [25]. Социальная изо-ляция меняет суточный ритм таких гормонов, как пролактин, гормон роста, лептин и кортикостерон [24].…”

Section: оригинальные исследованияunclassified

Astressin, an antagonist of CRF receptors, reduces anxiety and fobial states in rats reared in social isolation conditions

Лебедев

Андреевич²,

Pshenichnaya

et al. 2016

Rev Clin Pharm Drug Ther

View full text Add to dashboard Cite

The influence of intranasal administration of astressin, a nonselective antagonist of CRF receptors, on delayed effects of chronic social isolation in the five first weeks after mother leaving on explorative and emotional behavior in rats was studied. Social exposures were applied from 21st to 93rd days of life. The rats reared in social isolation demonstrated higher level of motor activity compared with control in open field test. The assessment of both anxiety and fobial state and behavior in elevated plus maze revealed higher levels in anxiety and fear in isolated rats. Intranasal administration of astressin (1 µg/1µl, 20 µl, 10 µl in every nostrils) reduced significantly anxiety and fear levels in isolated rats. Therefore, both anxiolytic and antifobial effects of astressin, a nonselective antagonist of CRF receptors, were demonstrated in rats exposured to social isolation stress. The results support the idea taking into account the corticoliberin mechanisms in formation of social isolation syndrome and possibilities of using CRF antagonists to control the central stress mechanisms and dependence in ontogeny.

show abstract

Co-occurrence of anxiety and depressive-like behaviors following adolescent social isolation in male mice; possible role of nitrergic system

Cited by 108 publications

References 60 publications

Adolescent Mice Are Resilient to Alcohol Withdrawal-Induced Anxiety and Changes in Indices of Glutamate Function within the Nucleus Accumbens

Adolescent Mice Are Resilient to Alcohol Withdrawal-Induced Anxiety and Changes in Indices of Glutamate Function within the Nucleus Accumbens

Aggression in non‐human vertebrates: Genetic mechanisms and molecular pathways

Astressin, an antagonist of CRF receptors, reduces anxiety and fobial states in rats reared in social isolation conditions

Contact Info

Product

Resources

About