Co-occurrence of Autism and Asthma in a Nationally-Representative Sample of Children in the United States

Kotey, Stanley; Ertel, Karen A.; Whitcomb, Brian W.

doi:10.1007/s10803-014-2174-y

Cited by 57 publications

(44 citation statements)

References 25 publications

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“…We found that children who are later diagnosed with ASD were not more likely than controls to be diagnosed with allergy, asthma, infections, autoimmune conditions, hematology, genitourinary, accidental injury, endocrine disorders or cardiovascular disorders in the years preceding ASD diagnosis. In contrast, some previous studies have reported that ASD is associated with comorbid medical conditions of allergies (Yaghmaie et al 2013; Theije et al 2014), asthma (Kotey et al 2014), infections (Atladottir et al 2010), autoimmune conditions (Gesundheit et al 2013), and endocrine disorders (Chen et al 2009). …”

Section: Discussionmentioning

confidence: 88%

Medical Conditions in the First Years of Life Associated with Future Diagnosis of ASD in Children

Alexeeff

Yau

Qian

et al. 2017

J Autism Dev Disord

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This study examines medical conditions diagnosed prior to the diagnosis of autism spectrum disorder (ASD). Using a matched case control design with 3911 ASD cases and 38,609 controls, we found that 38 out of 79 medical conditions were associated with increased ASD risk. Developmental delay, mental health, and neurology conditions had the strongest associations (ORs 2.0–23.3). Moderately strong associations were observed for nutrition, genetic, ear nose and throat, and sleep conditions (ORs 2.1–3.2). Using machine learning methods, we clustered children based on their medical conditions prior to ASD diagnosis and demonstrated ASD risk stratification. Our findings provide new evidence indicating that children with ASD have a disproportionate burden of certain medical conditions preceding ASD diagnosis.Electronic supplementary materialThe online version of this article (doi:10.1007/s10803-017-3130-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 88%

Medical Conditions in the First Years of Life Associated with Future Diagnosis of ASD in Children

Alexeeff

Yau

Qian

et al. 2017

J Autism Dev Disord

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“…This was because the coexistence of asthma with complicated morbidities has a significant impact on the health outcomes of children. 33,34…”

Section: Settings and Participantsmentioning

confidence: 99%

Acceptance and Commitment Therapy for Parental Management of Childhood Asthma: An RCT

et al. 2019

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BACKGROUND: Few trials have been conducted to address the psychological difficulties of parents in managing their child's asthma. Fostering parental psychological flexibility through Acceptance and Commitment Therapy (ACT) may help parents to accept these psychological difficulties and improve their management of childhood asthma. METHODS: In this randomized controlled trial, a 4-session, group-based ACT plus asthma education (ACT group) was compared with an asthma education talk plus 3 telephone followups (control group) to train parents of children diagnosed with asthma. The use of health care services due to asthma exacerbations in children and the psychological well-being of their parents were assessed before, immediately after, and at 6 months after the intervention. RESULTS: A total of 168 parents and their children aged 3 to 12 years with asthma were consecutively recruited in a public hospital in Hong Kong. When compared with the control group, children whose parents were in the ACT group made significantly fewer emergency department visits (adjusted 6-month incidence rate ratio = 0.20; confidence interval [CI] 0.08 to 0.53; P = .001) due to asthma exacerbations at 6 months postintervention. These parents also reported a decrease in psychological inflexibility (mean difference = 25.45; CI 27.71

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“…Perhaps not surprisingly, levels of asthma, a disease associated with air pollution-induced inflammation [64-67], are substantially higher in children with ASD, consistent with common inflammatory mechanisms in lung and brain. In a nationally representative sample of 77,951 children, asthma was 35% more common in those with ASD after controlling for age, gender, body mass index, race, brain injury, secondhand smoke and socioeconomic status [68]; further the prevalence of both ASD and asthma has been increasing [69,70]. …”

Section: Introductionmentioning

confidence: 99%

Developmental neurotoxicity of inhaled ambient ultrafine particle air pollution: Parallels with neuropathological and behavioral features of autism and other neurodevelopmental disorders

et al. 2017

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Accumulating evidence from both human and animal studies show that brain is a target of air pollution. Multiple epidemiological studies have now linked components of air pollution to diagnosis of autism spectrum disorder (ASD), a linkage with plausibility based on the shared mechanisms of inflammation. Additional plausibility appears to be provided by findings from our studies in mice of exposures from postnatal day (PND) 4-7 and 10-13 (human 3rd trimester equivalent), to concentrated ambient ultrafine (UFP) particles, considered the most reactive component of air pollution, at levels consistent with high traffic areas of major U.S. cities and thus highly relevant to human exposures. These exposures, occurring during a period of marked neuro- and gliogenesis, unexpectedly produced a pattern of developmental neurotoxicity notably similar to multiple hypothesized mechanistic underpinnings of ASD, including its greater impact in males. UFP exposures induced inflammation/microglial activation, reductions in size of the corpus callosum (CC) and associated hypomyelination, aberrant white matter development and/or structural integrity with ventriculomegaly (VM), elevated glutamate and excitatory/inhibitory imbalance, increased amygdala astrocytic activation, and repetitive and impulsive behaviors. Collectively, these findings suggest the human 3rd trimester equivalent as a period of potential vulnerability to neurodevelopmental toxicity to UFP, particularly in males, and point to the possibility that UFP air pollution exposure during periods of rapid neuro- and gliogenesis may be a risk factor not only for ASD, but also for other neurodevelopmental disorders that share features with ASD, such as schizophrenia, attention deficit disorder, and periventricular leukomalacia.

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Co-occurrence of Autism and Asthma in a Nationally-Representative Sample of Children in the United States

Cited by 57 publications

References 25 publications

Medical Conditions in the First Years of Life Associated with Future Diagnosis of ASD in Children

Medical Conditions in the First Years of Life Associated with Future Diagnosis of ASD in Children

Acceptance and Commitment Therapy for Parental Management of Childhood Asthma: An RCT

Developmental neurotoxicity of inhaled ambient ultrafine particle air pollution: Parallels with neuropathological and behavioral features of autism and other neurodevelopmental disorders

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