Co-occurrence of five Fusarium toxins in corn-Dried Distiller’s Grains with Solubles in Thailand and comparison of ELISA and LC-MS/MS for fumonisin analysis

Tansakul, Natthasit; Jala, P.; Laopiem, Sudtisa; Tangmunkhong, Prapeuk; Limsuwan, Sasithorn

doi:10.1007/s12550-013-0173-z

Cited by 30 publications

(19 citation statements)

References 17 publications

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“…In Finnish samples of grain-based products, concentrations of enniatins were found to have a statistically significant correlation with moniliformin concentrations (Jestoi et al, 2004b). Beauvericin was also found in all fumonisins-contaminated samples (99 %) of maize-dried distiller's grains with solubles from Thailand (Tansakul et al, 2013) and in all fumonisins-contaminated samples (96 %) of maize and poultry feed from Brazil (Mendes de Souza et al, 2013). Boutigny et al (2012) also reported a significant correlation between beauvericin and moniliformin levels in maize from South Africa.…”

Section: Co-occurrence Between Beauvericin and Enniatinsmentioning

confidence: 99%

Scientific Opinion on the risks to human and animal health related to the presence of beauvericin and enniatins in food and feed

2014

EFS2

222

117

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Beauvericin and enniatins are mycotoxins produced by various Fusarium species. The European Commission asked EFSA for a scientific opinion on the risk to human and animal health related to the presence of beauvericin and enniatins in food and feed. A total of 12 685 analytical results for beauvericin and enniatins in food, feed and unprocessed grains were evaluated. For the assessment of enniatins, the sum of enniatins A, A1, B and B1 were considered. The most important contributors to the chronic dietary exposure to beauvericin and the sum of enniatins were ‗Grains and grain-based products', especially ‗Bread and rolls', ‗Fine bakery wares' and ‗Pasta (raw)'. Given the lack of relevant toxicity data, a risk assessment was not possible. To obtain some insights in the possible risks of both mycotoxins at the estimated acute dietary exposure levels, these were compared to the LD 50 values of beauvericin and of the drug fusafungine (a mixture of enniatins). For the chronic exposure, an estimate for the LOAEL of fusafungine was considered. The CONTAM Panel concluded that acute exposure to beauvericin and enniatins do not indicate concern for human health. There might be a concern with respect to chronic exposure but no firm conclusion could be drawn, thus relevant in vivo toxicity data are needed to perform a human risk assessment. Animal exposure to beauvericin and enniatins was primarily from consuming cereal grains and cereal by-products. Using the LD 50 values of beauvericin and fusafungine, adverse health effects from the acute exposure to beauvericin and the sum of enniatins for farm and companion animals were unlikely. The chronic exposure for poultry indicated that adverse health effects from beauvericin and enniatins were unlikely. For other considered animals, the lack of LOAELs/NOAELs precluded the estimation of chronic health risk from beauvericin and enniatins. for the support provided to this scientific opinion. The CONTAM Panel acknowledges all European competent authorities that provided occurrence data on beauvericin and enniatins in food and feed, and supported the consumption data collection for the Comprehensive European Food Consumption Database. The Panel also acknowledges the research laboratories that provided additional occurrence data on beauvericin and enniatins in food and feed. Beauvericin and enniatins in food and feed EFSA Journal 2014;12(8):3802 3 quantification (LOQ) were 80 % for beauvericin and 63 % for enniatins in food, 79 % for beauvericin and 32 % for enniatins in feed, and 46 % for beauvericin and 24 % for enniatins in unprocessed grains.For enniatins, the CONTAM Panel decided to consider the sum of the concentrations of four enniatins, i.e. enniatins A, A1, B and B1, for the assessment since (i) these are the most frequently detected enniatins in foods and feeds, (ii) the toxicity database contained almost no data on individual enniatins but did contain some data on enniatin mixtures mainly containing these four toxins, and (iii) these enniatins are structurally similar and ha...

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Section: Co-occurrence Between Beauvericin and Enniatinsmentioning

confidence: 99%

Scientific Opinion on the risks to human and animal health related to the presence of beauvericin and enniatins in food and feed

2014

EFS2

222

117

View full text Add to dashboard Cite

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“…If a study reported ELISA and HPLC or GC MS/MS results for the same samples, it was assumed that the latter methods yielded more accurate levels than the ELISA technique (e.g. Tansakul et al 2013). These and additional uncertainties have been summarised in detail in a subsequent section in this study.…”

Section: Estimation Of the Mycotoxin Contamination Levels And Their Imentioning

confidence: 99%

Risk assessment for mycotoxin contamination in fish feeds in Europe

Pietsch

2019

Mycotoxin Res

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Mycotoxins are difficult to monitor continuously, and a tool to assess the risk would help to judge if there is a particular risk due to the inclusion of certain feed ingredients. For this, the toxin contents of 97 commercial fish feeds have been estimated, and the most prominent toxins in fish feed are calculated to be deoxynivalenol, zearalenone, fumonisins and enniatins. These pose a risk to fish well-being, as can be calculated by the Bayesian models for determining the critical concentrations 5% (CC5) for the different toxins. Besides fishmeal, wheat, soybean products and corn are regularly used as fish feed ingredients. The calculated scenarios show that fish are at high risk of toxin contamination if feed ingredients of low quality are chosen for feed production. Due to this, specific maximum allowable levels for several mycotoxins in fish feeds should be established.

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“…The mean BEA concentration was higher in swine (0.74 μg/g) and dairy cattle (0.72 μg/g) feeds than in beef cattle (0.43 μg/g) and chicken (0.37 μg/g) feeds. BEA is also detected in Irish farm silages (21.8 μg/kg) (McElhinney et al, 2015 ) and corn-dried distiller's grains in Thailand (350 μg/kg) (Tansakul et al, 2013 ).…”

Section: Risk Assessment Of Beauvericin In Food and Feedmentioning

confidence: 99%

A Review on the Synthesis and Bioactivity Aspects of Beauvericin, a Fusarium Mycotoxin

Patočka

Nepovimová

et al. 2018

Front. Pharmacol.

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Beauvericin (BEA) is an emerging Fusarium mycotoxin that contaminates food and feeds globally. BEA biosynthesis is rapidly catalyzed by BEA synthetase through a nonribosomal, thiol-templated mechanism. This mycotoxin has cytotoxicity and is capable of increasing oxidative stress to induce cell apoptosis. Recently, large evidence further shows that this mycotoxin has a variety of biological activities and is being considered a potential candidate for medicinal and pesticide research. It is noteworthy that BEA is a potential anticancer agent since it can increase the intracellular Ca2+ levels and induce the cancer cell death through oxidative stress and apoptosis. BEA has exhibited effective antibacterial activities against both pathogenic Gram-positive and Gram-negative bacteria. Importantly, BEA exhibits an effective capacity to inhibit the human immunodeficiency virus type-1 integrase. Moreover, BEA can simultaneously target drug resistance and morphogenesis which provides a promising strategy to combat life-threatening fungal infections. Thus, in this review, the synthesis and the biological activities of BEA, as well as, the underlying mechanisms, are fully analyzed. The risk assessment of BEA in food and feed are also discussed. We hope this review will help to further understand the biological activities of BEA and cast some new light on drug discovery.

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Co-occurrence of five Fusarium toxins in corn-Dried Distiller’s Grains with Solubles in Thailand and comparison of ELISA and LC-MS/MS for fumonisin analysis

Cited by 30 publications

References 17 publications

Scientific Opinion on the risks to human and animal health related to the presence of beauvericin and enniatins in food and feed

Scientific Opinion on the risks to human and animal health related to the presence of beauvericin and enniatins in food and feed

Risk assessment for mycotoxin contamination in fish feeds in Europe

A Review on the Synthesis and Bioactivity Aspects of Beauvericin, a Fusarium Mycotoxin

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