Co-occurrence of Functional Gonadotroph Adenoma and Lactotroph Adenoma: A Case Report and Literature Review

Ullah, Mohammad T.; Lopes, M. Beatriz S.; Jane, John A.; Hong, Gregory K.; Love, Kaitlin

doi:10.1016/j.aace.2022.11.001

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…The following articles were excluded: (1) articles not published in English, (2) no surgical treatment was performed, (3) no hormonal abnormalities or related endocrine symptoms prior to surgery, (4) no mention of postoperative biochemical remission results in the text, (5) two tumors that were not concurrent, namely recurrent pituitary adenomas. Finally, 57 patients from 22 articles ( 7 – 28 ) met the inclusion criteria, adding 2 patients reported in the paper, a total of 59 patients with functional pituitary adenomas were included in the systematic review.…”

Section: Methodsmentioning

confidence: 99%

Double pituitary adenomas: report of two cases and systematic review of the literature

Zhang,

Gong,

et al. 2024

Front. Endocrinol.

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ObjectiveDouble pituitary adenomas (DPA) are a rare clinical condition, and our knowledge of them is limited. Missing the second lesion leading to incomplete biochemical remission after surgery is an important challenge in DPA management. This study aims to analyze independent prognostic factors in DPA patients and summarize clinical experiences to prevent surgical failure.MethodsTwo cases of DPA patients with Cushing’s disease diagnosed and surgically treated at Peking Union Medical College Hospital are reported. A literature review was performed on the online database Pubmed, and 57 DPA patients from 22 retrieved articles were included. Demographic characteristics, endocrine manifestations, diagnostic methods, tumor size, and immunohistochemical features of 59 patients were analyzed. Binary logistic regression models were used to identify independent prognostic factors affecting postoperative biochemical remission.ResultsAmong 59 DPA patients, the mean ± SD age was 43.64 ± 14.42 years, with 61.02% being female (n = 36). The most common endocrine manifestations were Cushing’s syndrome (23/59, 38.98%) and acromegaly (20/59, 33.90%). The most prevalent immunohistochemical types were ACTH-immunopositive (31/118, 26.27%) and GH-immunopositive (31/118, 26.27%) tumors. Microadenomas (<1cm) were the most frequent in terms of tumor size (62/92, 67.39%). The detection rate for double lesions on 3.0T MRI was 50.00% (14/28), which significantly higher than 1.5T MRI (P = 0.034). Univariate analysis revealed that female, Cushing’s syndrome and only single lesion detected by surgical exploration were associated with significantly worse prognosis (P<0.05). Multivariate analysis identified double lesion detected by surgical exploration (OR = 0.08, P = 0.003) and contiguous type tumor (OR = 0.06, P = 0.017) as independent protective factors for DPA patients.ConclusionsThe double lesion detected by surgical exploration is independently associated with a better prognosis for DPA patients. Comprehensive intraoperative exploration are crucial measures to avoid missing causative lesions.

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Section: Methodsmentioning

confidence: 99%

Double pituitary adenomas: report of two cases and systematic review of the literature

Zhang,

Gong,

et al. 2024

Front. Endocrinol.

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“… 1 In another case, authors suggested the co-occurrence of both functional gonadotroph adenoma with a lactotroph adenoma in patients who present with elevated gonadotropin levels despite hyperprolactinemia. 2 …”

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confidence: 99%

Editorial for January/February Issue of AACE Clinical Case Reports

Jasim

2023

AACE Clinical Case Reports

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Successful Multimodal Management of an Aggressive Functional Gonadotropic Pituitary Macroadenoma

Feng,

Cannon,

Cheok

et al. 2024

AACE Clinical Case Reports

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Co-occurrence of Functional Gonadotroph Adenoma and Lactotroph Adenoma: A Case Report and Literature Review

Cited by 4 publications

References 19 publications

Double pituitary adenomas: report of two cases and systematic review of the literature

Double pituitary adenomas: report of two cases and systematic review of the literature

Editorial for January/February Issue of AACE Clinical Case Reports

Successful Multimodal Management of an Aggressive Functional Gonadotropic Pituitary Macroadenoma

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