Co-occurrence of Gilbert's syndrome and psychosis

Mahdi, Ali Sabah; Elameer, M. S.

doi:10.1192/pb.22.9.566

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…Gilbert's Syndrome (Su-eMizaj Har Safrawi) is the most common form of congenital, non-hemolytic, 2 mild unconjugated hyperbilirubinemia 1, 14 found in 2-19% of population 15,16 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2015

IJPSR

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Background: Gilbert's syndrome (GS) is the most common form of congenital, non haemolytic, mild unconjugated hyperbilirubinaemia. Familial cases linked with mutation in enzyme UDP glucuronosyl transferase 1 producing decreased conjugation of bilirubin which accumulates in the form of unconjugated bilirubin. Hyperbilirubinaemia is mild (<6 mg/dl) while liver enzymes & histology are always found normal. It is clinically characterized by vague symptoms like loss of appetite, abdominal pain, weight loss and mild Jaundice. A review of Unani literature showed disease similarity clinically with Su-e-Mizaj Jigar Har Yabis, with dominating features of Safra (yellow bile). Material and Methods: We report our experience with such a case of GS by validated integrative assessment and management with Unani medicine e.g. Arqayat (Makoh+Kasni+Biranjasif), Jigreen, Sharbat-e-Bazoori and Majoon Dabid-ul-Ward along with a short review of literature. Results were analyzed based on clinical and LFT outcomes. Results: Significant symptomatic relief was achieved over 5 weeks of treatment. Bilirubin levels normalized but rose after 5 weeks. Literature review showed disease similarity with Su-e-Mizaj Har Yabis Sadaa which under the aggravating factors progressed to Su-e-Mizaj Har Safrawi. Conclusion: As single abnormal gene in the GS runs in the families & leads to reduced enzymatic expression. This decreases conjugation of unconjugated bilirubin and ultimately unconjugated hyperbilirubinaemia. Thereby normal levels of bilirubin were achieved for concise period of time with symptomatic relief which proves the effectiveness of Unani medicine in GS but establishment of the therapy needs planned study on multiple patients.

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“…Gilbert's Syndrome (Su-eMizaj Har Safrawi) is the most common form of congenital, non-hemolytic, 2 mild unconjugated hyperbilirubinemia 1, 14 found in 2-19% of population 15,16 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2015

IJPSR

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Alteration of serum bilirubin level in schizophrenia

Semnani

Nazemi

Azari-Yam

et al. 2010

International Journal of Psychiatry in Clinical Practice

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Objective. Alteration of serum bilirubin level in acute episodes of psychosis in patients with schizophrenia has been reported but the pattern of this alteration is controversial. Methods. Patients diagnosed as schizophrenia (162, group S) or bipolar disorder (155, group B) entered the study. The control group consisted of 95 patients admitted to cardiac care unit who had no personal or family history of major psychiatric disorders. Pre- and post-admission levels of bilirubin were measured and compared within and between the groups. Patients were examined to exclude all other causes of hyperbilirubinemia. Group S and B participants were also evaluated using positive and negative syndrome subscale (PANSS) both at admission and discharge. Results. The mean admission bilirubin levels of all the groups were in the normal range (significantly higher in group S than groups B and C) and were affected by the score of general psychopathology subscale rather than the scores of positive symptoms subscale. Conclusions. Although bilirubin decreased in all three groups at discharge, the rate of decrease was significantly higher in group S. The reason for this is not clear and needs further study.

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Co-occurrence of Gilbert's syndrome and psychosis

Cited by 2 publications

References 6 publications

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Alteration of serum bilirubin level in schizophrenia

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