Co-occurrence of migraine and atopy in children and adolescents: myth or a casual relationship?

Özge, Aynur; Uludüz, Derya; Bolay, Hayrünnisa

doi:10.1097/wco.0000000000000439

Cited by 17 publications

(19 citation statements)

References 37 publications

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“…The results of our study are in agreement with those of previous studies in adults and children [6][7][8][9][10][11][12] in that the prevalence of headache was higher in the allergic group than the nonallergic group. Our allergic group consisted of various types of allergy including allergic rhinitis, asthma, atopic dermatitis, and atopic conjunctivitis.…”

Section: Discussionsupporting

confidence: 93%

“…Genetic, environment, and systemic inflammatory response may contribute to headache in chronic allergic disease. 11 A population-based study evaluating the health-related quality of life (HRQoL) in adult headache patients has shown that this comorbid condition is associated with low HRQoL scores. 12 This study aimed to investigate the prevalence of headache in allergic children.…”

Section: Introductionmentioning

confidence: 99%

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Association between Childhood Allergic Diseases and Headache

Charoensanti

Uthaisangsook

Padsee

et al. 2020

Journal of Pediatric Neurology

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Allergic disorders and headache are both common in pediatric populations. Chronic allergic disorders may affect sleep leading to chronic daily headaches. Poor controlled allergies may cause neurogenic inflammation that may be a predisposing factor to migraine headaches. We hypothesized that a higher prevalence of headaches may be found in children with allergy compared with those without allergy. Patients with either multiple allergic disorders or with poorly controlled allergic symptoms may be associated with headaches, especially migraine headaches. This study aimed to examine (1) the prevalence of headache in allergic children and (2) the association between allergic diseases and headache. Patients with allergic diseases and nonallergic children as control were recruited in the pediatric outpatient clinic of Naresuan University Hospital between January 2017 and January 2018. A neurological examination was performed by a pediatric neurologist. The questionnaire consisted of the pediatric headache symptom checklist and the items for evaluation of allergy control status. The diagnosis and classification of headache were based on the International Classification of Headache Disorders-3 criteria. The results were analyzed using the Student's t-test, chi-squared tests, odds ratios, and 95% confidence interval. One hundred fifty-five subjects were enrolled in our study, of which 85 subjects (54.8%) were diagnosed with allergic diseases. The allergic group had a significantly higher prevalence of headache than the control group (37 [43.5%] vs. 19 [27.1%], p = 0.035). The allergic group also had a significantly higher prevalence of migraine and probable migraine headache than the control group (23 [27.06%] vs. 7 [10%], p = 0.007). The prevalence of headache did not increase in subjects who had more than one allergic disease. There was no association between the control of allergy and headache. The present study showed that allergic diseases were associated with increased prevalence of headache and migraine in children. However, the control of allergic symptoms and the number of allergic diseases were not associated with headache. The physicians should be aware of headache in allergic patients and give appropriate treatment. Further study would be to identify specific biomarkers for the development of better treatment in these comorbid diseases.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Association between Childhood Allergic Diseases and Headache

Charoensanti

Uthaisangsook

Padsee

et al. 2020

Journal of Pediatric Neurology

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“…The proportion of eosinophils in WBC counts was increased, whereas, in men, the levels of inflammatory markers were consistently lower than those in other classes. The atopic class included enhanced risk for irritable bowel syndrome, cystitis, and migraine [49]. It was associated with mental disorders both in boys/men and in girls/women.…”

Section: Discussionmentioning

confidence: 99%

A step beyond the hygiene hypothesis—immune-mediated classes determined in a population-based study

Ajdacic-Gross

Mütsch

Rodgers

et al. 2019

BMC Med

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Background Comorbidity patterns of childhood infections, atopic diseases, and adverse childhood experiences (ACE) are related to immune system programming conditions. The aim of this study was to make a step beyond the hygiene hypothesis and to comprehensively classify these patterns with latent class analysis (LCA). A second aim was to characterize the classes by associations with immunological, clinical, and sociodemographic variables. Methods LCA was applied to data from the CoLaus|PsyCoLaus study ( N = 4874, age range 35–82 years) separately for men and women. It was based on survey information on chickenpox, measles, mumps, rubella, herpes simplex, pertussis, scarlet fever, hay fever, asthma, eczema, urticaria, drug allergy, interparental violence, parental maltreatment, and trauma in early childhood. Subsequently, we examined how immune-mediated classes were reflected in leukocyte counts, inflammatory markers (IL-1β, IL-6, TNF-α, hsCRP), chronic inflammatory diseases, and mental disorders, and how they differed across social classes and birth cohorts. Results LCA results with five classes were selected for further analysis. Latent classes were similar in both sexes and were labeled according to their associations as neutral, resilient, atopic, mixed (comprising infectious and atopic diseases), and ACE class. They came across with specific differences in biomarker levels. Mental disorders typically displayed increased lifetime prevalence rates in the atopic, the mixed, and the ACE classes, and decreased rates in the resilient class. The same patterns were apparent in chronic inflammatory diseases, except that the ACE class was relevant specifically in women but not in men. Conclusions This is the first study to systematically determine immune-mediated classes that evolve early in life. They display characteristic associations with biomarker levels and somatic and psychiatric diseases occurring later in life. Moreover, they show different distributions across social classes and allow to better understand the mechanisms beyond the changes in the prevalence of chronic somatic and psychiatric diseases.

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“…Similarly, via neurogenic inflammation and local immune activation, CGRP may participate in psoriasis and possibly rosacea and atopic dermatitis . As there may be pathophysiological links between migraine and atopic dermatitis, there could be dual benefit in CGRP blockade.…”

Section: Potential Benefits Of Blocking Cgrpmentioning

confidence: 99%

CGRP and Brain Functioning: Cautions for Migraine Treatment

Borkum

2019

Headache

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Background Calcitonin gene‐related peptide has emerged as a therapeutic target in migraine. Monoclonal antibodies and small molecule receptor antagonists (gepants) directed against CGRP have been approved or are in Phase II or III clinical trials. For monitoring the long‐term safety of these drugs, it is helpful to consider the role of CGRP in brain functioning. Methods Qualitative review of the preclinical literature on CGRP in brain physiology and pathophysiology. Results Within the brain, CGRP is upregulated by stresses such as ischemia, injury, hyperthermia, and seizure, and activates neuroprotective processes. Thus, CGRP buffers intracellular calcium, triggers antiapoptotic signaling, upregulates a number of neurotrophins (including insulin‐like growth factor‐1/IGF‐1, basic fibroblast growth factor/bFGF, and nerve growth factor/NGF), reduces brain edema, and likely increases antioxidant defenses. When released outside the blood‐brain barrier, CGRP likely protects the endothelium, upregulates growth factor signaling from the endothelium to the brain parenchyma, strengthens the blood‐brain barrier, protects the immune privilege of the brain by inhibiting the movement of neutrophils and monocytes, and facilitates neurogenesis and angiogenesis at stem cell niches. Conclusions CGRP participates in a wide range of neuroprotective processes. In theory, migraineurs with comorbid brain pathology might be at increased risk from CGRP inhibition. However, the extent of compensating processes is unknown and will determine whether these risks materialize in practice.

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Co-occurrence of migraine and atopy in children and adolescents: myth or a casual relationship?

Abstract: On the basis of clinical features, laboratory findings and some practical clues in children, accurate diagnosis of migraine and atopic disorders are very critical for physicians, pediatricians and algologists.

Cited by 17 publications

References 37 publications

Association between Childhood Allergic Diseases and Headache

Association between Childhood Allergic Diseases and Headache

A step beyond the hygiene hypothesis—immune-mediated classes determined in a population-based study

CGRP and Brain Functioning: Cautions for Migraine Treatment

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