Co-occurrence of Warthin’s tumor with oral squamous cell carcinoma – Overlapping risk factors and implications

Bhatlawande, Harshada; Desai, Karishma Madhusudan; Kale, Alka D; Angadi, Punnya V.; Hallikerimath, Seema; Chibborah, Rebekah

doi:10.1016/j.oraloncology.2019.104449

Cited by 5 publications

(38 citation statements)

References 9 publications

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“…WT occurs in older adults, mostly in their sixth and seventh decades whereas, OSCC occurs mostly in the sixth decade. Both our cases occurred in elderly patients, which is similar to the previously reported cases (range 51-77 years) [ 11 , 13 - 20 ]. Both WT and OSCC have noted a strong male predilection [ 1 , 2 ].…”

Section: Discussionsupporting

confidence: 91%

“…Among the nine cases of synchronous WT with OSCC, only one case reported WT in the lower pole of the parotid gland [17], similar to the present case series, which is the predominant site of occurrence for this tumour when occurring alone. However, the other cases reported WT in cervical lymph nodes [11,[13][14][15][16][18][19][20].…”

Section: Discussionmentioning

confidence: 99%

“…Synchronous occurrence of WT in the cervical and peri parotid lymph nodes with oral or laryngeal squamous cell carcinoma has been reported. WT may also occur synchronously with other neoplasms [ 11 ]. Shikhani et al reported the synchronous occurrence of WT with a malignant lymphoma and an oncocytoma within the same parotid gland in their series of two cases ]12].…”

Section: Discussionmentioning

confidence: 99%

“…To date, there have been only nine cases that have been reported as the synchronous occurrence of WT with OSCC (Table 1 ) [ 11 , 13 - 20 ]. Only Nupehewa et al have reported a synchronous occurrence of OSCC of the buccal mucosa with WT of the lower pole of the parotid gland similar to the present cases [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…The synchronous occurrence of WT either in the cervical lymph nodes [11,[13][14][15][16][18][19][20] or in the tail of parotid [17], as reported in this case series, results in diagnostic difficulties and inaccurate staging to the radiologist and treating surgeons as cervical lymph nodes and tail of parotid can be sites for metastases of the primary OSCC. These difficulties have been highlighted in some of the cases reported in the literature [18][19][20], especially when using 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET/CT), which results in false positive results of FDG-positive WT.…”

Section: Publicationmentioning

confidence: 92%

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Oral Squamous Cell Carcinoma and Warthin Tumour Occurring As Synchronous Tumours: A Report of Two Cases

Ching¹,

Ramanathan²,

Kallarakkal³

et al. 2022

Cureus

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Oral cancer is a common site of cancer worldwide with oral squamous cell carcinoma (OSCC) comprising the major segment. The risk factors include tobacco and alcohol abuse, betel quid, and areca nut consumption. Warthin tumour (WT), also known as papillary cystadenoma lymphomatosum is a benign tumour of the salivary gland. It is one of the most common benign parotid neoplasms with cigarette smoking and radiation exposure as possible cited etiologic factors. Rarely, two or more histologically distinct neoplasms may occur synchronously. The synchronous occurrence of OSCC and WT is infrequent.The aim of this case series is to report the incidence rate of synchronous OSCC and WT in our centre between 2010 and 2019 and their socio-demographic, clinical, histopathological features, management, and prognosis and discuss the relevant literature. Out of 143 OSCC cases reported in our centre from the year 2010 to 2019, two had synchronous OSCC and WT with an incidence rate of 1.4%. These two cases occurred in a 63-year-old female and a 68-year-old male both with smoking habits. One OSCC was present in the left buccal mucosa and the other in the right ventral surface of the tongue, whereas the WT in both cases occurred in the tail of the parotid. One patient had a recurrence and died while the other is under follow-up without any recurrence.These unusual findings of synchronous occurrence of WT at a distant site from the primary tumour may mimic a malignant disease, more likely a metastasis from the primary OSCC, which could further complicate the management of these patients. Therefore, radiologists, head and neck surgeons, and pathologists should be aware of the occurrence of these unusual presentations to avoid overtreatment in such cases.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Publicationmentioning

confidence: 92%

See 3 more Smart Citations

Oral Squamous Cell Carcinoma and Warthin Tumour Occurring As Synchronous Tumours: A Report of Two Cases

Ching¹,

Ramanathan²,

Kallarakkal³

et al. 2022

Cureus

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Concurrent squamous cell carcinoma and warthin tumor - A rare encounter

Deorah,

Raghuvanshi,

John

et al. 2024

Oral Oncology Reports

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A Rare Synchronous Existence of Warthin’s Tumour and Oral Cancer

Sarode,

Mahindre,

Mehta

et al. 2024

Sultan Qaboos Univ Med J

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Oral squamous cell carcinoma (OSCC) is one of the most common malignancies worldwide while Warthin’s tumor (WT) is a common type of benign salivary gland neoplasm mostly seen in the parotid gland but rarely involves extra parotid tissues. Extra parotid WT is itself a rare entity and its synchronous occurrence with OSCC is an unusual phenomenon. It is vital to accurately identify the pathology as confusion may arise due to its rare occurrence and an intriguing presentation of resembling metastasis in lymph nodes. In the present review, a systematic literature search was performed and case reports and series in which synchronous existence of WT and OSCC were included. Total 13 papers have been included with 17 cases of synchronous WT and OSCC. Quality assessment for cases was done based on the CARE guidelines. The given results describe the histological features and site of WT in individuals who also had OSCC. Most of the studies described the histological findings of WT, which were seen involving the lymph nodes. More than 50% of the included cases had a history of tobacco chewing or smoking. The cases that have reported for follow up showed no evidence of any recurrence. WT with OSCC synchronous occurrence at a different site from the primary tumor can mimic a metastatic lesion from a primary lesion. It is a diagnostic challenge and could alter the management of these patients if not identified accurately. Awareness about this synchronous occurrence can avoid the overtreatment in such cases. Majority of the WTs described were seen in cervical lymph nodes. Keywords: Oral cancer; Warthin tumor; Benign Neoplasm; Mixed salivary gland tumor; Synchronous neoplasm; metastasis; Second malignancy; Prognosis.

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Co-occurrence of Warthin’s tumor with oral squamous cell carcinoma – Overlapping risk factors and implications

Cited by 5 publications

References 9 publications

Oral Squamous Cell Carcinoma and Warthin Tumour Occurring As Synchronous Tumours: A Report of Two Cases

Oral Squamous Cell Carcinoma and Warthin Tumour Occurring As Synchronous Tumours: A Report of Two Cases

Concurrent squamous cell carcinoma and warthin tumor - A rare encounter

A Rare Synchronous Existence of Warthin’s Tumour and Oral Cancer

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