2021
DOI: 10.1186/s12876-021-01814-5
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Co-occurrence of Wilson’s disease and systemic lupus erythematosus: a case report and literature review

Abstract: Background Wilson’s disease (WD) is a rare autosomal recessive disease associated with defective biliary excretion of copper. The simultaneous occurrence of WD and systemic lupus erythematosus (SLE) has seldom been reported. Therefore, this study aimed to report the co-occurrence of SLE and WD with hepatic involvement in a patient so as to improve the understanding of the coexistence of these two conditions. Case presentation A 35-year-old woman wi… Show more

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Cited by 5 publications
(5 citation statements)
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“…However, penicillamine is not recommended for patients with coexisting WD and SLE due to the potential for the induction of lupus. Because WD was not induced by penicillamine use in our patient, we reviewed other reports of WD with SLE not induced by penicillamine use and identified ten other patients in addition to our patient [ 17 , 20 28 ]. Among these patients, six received therapy with intravenous sodium dimercaptopropane sulfonate and/or oral zinc sulfate, which led to an improvement in WD symptoms [ 20 , 23 – 27 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…However, penicillamine is not recommended for patients with coexisting WD and SLE due to the potential for the induction of lupus. Because WD was not induced by penicillamine use in our patient, we reviewed other reports of WD with SLE not induced by penicillamine use and identified ten other patients in addition to our patient [ 17 , 20 28 ]. Among these patients, six received therapy with intravenous sodium dimercaptopropane sulfonate and/or oral zinc sulfate, which led to an improvement in WD symptoms [ 20 , 23 – 27 ].…”
Section: Discussionmentioning
confidence: 99%
“…Because WD was not induced by penicillamine use in our patient, we reviewed other reports of WD with SLE not induced by penicillamine use and identified ten other patients in addition to our patient [ 17 , 20 28 ]. Among these patients, six received therapy with intravenous sodium dimercaptopropane sulfonate and/or oral zinc sulfate, which led to an improvement in WD symptoms [ 20 , 23 – 27 ]. In one patient, penicillamine was initially prescribed but was changed to oral zinc due to worsening central nervous system symptoms after two weeks; however, the patient unfortunately passed away 41 days after admission [ 17 ].…”
Section: Discussionmentioning
confidence: 99%
“…WD is an inherited monogenic disorder characterized by significant copper accumulation in various tissues and organs due to mutations in the ATP7B gene, leading to a wide range of clinical manifestations ( 9 ). Liver dysfunction, including acute or chronic hepatitis, acute liver failure, cirrhosis, hepatic encephalopathy, fulminant hepatitis, and asymptomatic liver biochemical abnormalities ( 10 , 11 ), is one of the most common symptom associated with WD. Similarly, SLE can also cause abnormal liver damage.…”
Section: Discussionmentioning
confidence: 99%
“…However, penicillamine is not recommended in patients with coexisting WD and SLE due to the potential induction of lupus. In the limited literature available on the coexistence of WD and SLE, we identi ed nine other patients apart from our patient [17][18][19][20][21][22][23][24][25]. Among these patients, six received therapy with intravenous sodium dimercaptopropane sulfonate and/or oral zinc sulfate, which led to an improvement in WD symptoms [17,20,[22][23][24][25].…”
Section: Autoimmune Hepatitis (Aih) Is a Chronic Liver Disease Of Unk...mentioning
confidence: 99%
“…In the limited literature available on the coexistence of WD and SLE, we identi ed nine other patients apart from our patient [17][18][19][20][21][22][23][24][25]. Among these patients, six received therapy with intravenous sodium dimercaptopropane sulfonate and/or oral zinc sulfate, which led to an improvement in WD symptoms [17,20,[22][23][24][25]. In one patient, penicillamine was initially prescribed but was changed to oral zinc due to worsening central nervous system symptoms after two weeks; however, the patient unfortunately passed away 41 days after admission [21].…”
Section: Autoimmune Hepatitis (Aih) Is a Chronic Liver Disease Of Unk...mentioning
confidence: 99%