Academic entrepreneurship by means of university spinoffs commercializes technological breakthroughs, which may otherwise remain unexploited. However, many universities face difficulties in creating spinoffs. This article adopts a science-based design approach, to connect scholarly research with the pragmatics of effectively creating university spinoffs. This approach serves to link the practice of university spinoff creation, via design principles, to the scholarly knowledge in this area. As such, science-based design promotes the interplay between emergent and deliberate design processes. This framework is used to develop a set of design principles that are practice-based as well as grounded in the existing body of research on university spinoffs. A case-study of spinoff creation at a Dutch university illustrates the interplay between initial processes characterized by emergent design and the subsequent process that was more deliberate in nature. This case study also suggests there are two fundamentally different phases in building capacity for university spinoff creation: first, an infrastructure for spinoff creation (e.g. including a collaborative network of investors, managers and advisors) is developed, that then enables support activities to individual spinoff ventures. This study concludes that, to build and increase capacity for creating spinoffs, universities should:1. create university-wide awareness of entrepreneurship opportunities, stimulate the development of entrepreneurial ideas, and subsequently screen entrepreneurs and ideas by programs targeted at students and academic staff; 2. support start-up teams in composing and learning the right mix of venturing skills and knowledge by providing access to advice, coaching and training; 3. help starters in obtaining access to resources and developing their social capital by creating a collaborative network organization of investors, managers and advisors; 4. set clear and supportive rules and procedures that regulate the university spinoff process, enhance fair treatment of involved parties, and separate spinoff processes from academic research and teaching; 5. shape a university culture that reinforces academic entrepreneurship, by creating norms and exemplars that motivate entrepreneurial behavior. These and other results of this study illustrate how science-based design can connect scholarly research to the pragmatics of actually creating spinoffs in academic institutions.2