Co‐Quenching Effect between Lanthanum Metal–Organic Frameworks Luminophore and Crystal Violet for Enhanced Electrochemiluminescence Gene Detection

Gao, Huan; Wei, Xuan; Li, Meize; Wang, Lei; Wei, Tianxiang; Dai, Zhihui

doi:10.1002/smll.202103424

Cited by 24 publications

(15 citation statements)

References 60 publications

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“…Based on the long lifetime excited states of lanthanide cations, lanthanide MOFs are promising candidates as ECL luminophores without an extra luminophore . The lanthanide MOFs as ECL signal emitters composed of a Eu(III) ion and 5-boronoisophthalic acid have uniform spherical shape with a 45 nm particle size.…”

Section: Structural Design Of Reticular Ecl Nanoemittersmentioning

confidence: 99%

Reticular Electrochemiluminescence Nanoemitters: Structural Design and Enhancement Mechanism

Luo

Zhu

et al. 2023

Acc. Chem. Res.

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Metrics & MoreArticle Recommendations CONSPECTUS: Electrochemiluminescence (ECL) is a powerful transduction technique, which depends critically on the formation of the excited emitter through the charge transfer between the electrochemical reaction intermediates of the emitter and the co-reactant/emitter. The exploration of ECL mechanisms for conventional nanoemitters is limited due to the uncontrollable charge transfer process. With the development of molecular nanocrystals, reticular structures such as metal−organic frameworks (MOFs) and covalent organic frameworks (COFs) have been utilized as atomically precise semiconducting materials. The long-range order in crystalline frameworks and the tunable coupling among building blocks promote the quick development of electrically conductive frameworks. Especially, the reticular charge transfer can be regulated by both interlayer electron coupling and intralayer topology-templated conjugation. By modulating intramolecular or intermolecular charge mobility, reticular structures could serve as promising candidates for enhancing ECL. Thus, reticular crystalline nanoemitters with different topologies provide a confined platform to understand ECL fundamentals for designing next-generation ECL devices.Aiming at exploring the mechanism of ECL emission, our group has developed a series of ECL nanoemitters as well as enhancement strategies of ECL emission in the past 20 years. A series of water-soluble ligandcapped quantum dots were introduced as ECL nanoemitters to create sensitive analytical methods for detecting and tracing biomarkers. The functionalized polymer dots were also designed as ECL nanoemitters for imaging of membrane proteins with signal transduction strategies of dual resonance energy transfer and dual intramolecular electron transfer. To decode the ECL fundamental and enhancement mechanisms, an electroactive MOF with accurate molecular structure was first constructed with two redox ligands as a highly crystallized ECL nanoemitter in aqueous medium. Through the mixed-ligand approach, luminophores and co-reactants were integrated into one MOF structure for self-enhanced ECL. Furthermore, several donor−acceptor COFs were developed as efficient ECL nanoemitters with tunable intrareticular charge transfer. The atomically precise structure of conductive frameworks established clear correlations between the structure and charge transport in these materials. Therefore, reticular materials as crystalline ECL nanoemitters have demonstrated both proof of concept and mechanistic innovation.In this Account, taking advantage of reticular materials with accurate molecular structure, we survey the design of the electroactive reticular materials including MOFs and COFs as crystalline ECL nanoemitters at the molecular level. The enhancement mechanisms of ECL emission of various topology frameworks are discussed via the regulation of reticular energy transfer and charge transfer and the accumulation of anion/cation radicals. Our perspective on the reticular ECL nanoemitters is ...

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Section: Structural Design Of Reticular Ecl Nanoemittersmentioning

confidence: 99%

Reticular Electrochemiluminescence Nanoemitters: Structural Design and Enhancement Mechanism

Luo

Zhu

et al. 2023

Acc. Chem. Res.

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“…MOFs have not only excellent porous properties (e.g., high specific surface area and high porosity) but also many advantages such as structure design and function adjustment, so they have been widely applied in gas adsorption and separation [ 89 , 90 ] , chemical sensing [ 91 , 92 ] , heterogeneous phase catalysis, biological diagnosis [ 93 , 94 ] , and cancer therapy. In view of the flexibility in the design and synthesis of MOF materials, it is convenient to introduce primitives into MOFs through metal nodes, ligands, and guests to endow such materials with unique activities, thereby constructing multifunctional MOFs.…”

Section: Metal-organic Framework Nanosystemmentioning

confidence: 99%

Perspectives of metal-organic framework nanosystem to overcome tumor drug resistance

Wang¹,

Shi²,

Yang³

et al. 2022

Cancer Drug Resist

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Cancer is one of the most harmful diseases in the world, which causes huge numbers of deaths every year. Many drugs have been developed to treat tumors. However, drug resistance usually develops after a period of time, which greatly weakens the therapeutic effect. Tumor drug resistance is characterized by blocking the action of anticancer drugs, resisting apoptosis and DNA repair, and evading immune recognition. To tackle tumor drug resistance, many engineered drug delivery systems (DDS) have been developed. Metal-organic frameworks (MOFs) are one kind of emerging and promising nanocarriers for DDS with high surface area and abundant active sites that make the functionalization simpler and more efficient. These features enable MOFs to achieve advantages easily towards other materials. In this review, we highlight the main mechanisms of tumor drug resistance and the characteristics of MOFs. The applications and opportunities of MOF-based DDS to overcome tumor drug resistance are also discussed, shedding light on the future development of MOFs to address tumor drug resistance.

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“…A quenching strategy was adopted in an ECL-RET system to sensitively detect various biomarkers such as the p53 gene and retinol-binding protein [ 42 , 43 , 44 ]. In this ECL system, a lanthanide MOF and S 2 O 8 2− were used as the luminophore and co-reactant, respectively.…”

Section: Current Strategies and Technologies Of The Ecl Systems In Th...mentioning

confidence: 99%

Electrochemiluminescence Systems for the Detection of Biomarkers: Strategical and Technological Advances

2022

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Electrochemiluminescence (ECL)-based sensing systems rely on light emissions from luminophores, which are generated by high-energy electron transfer reactions between electrogenerated species on an electrode. ECL systems have been widely used in the detection and monitoring of diverse, disease-related biomarkers due to their high selectivity and fast response times, as well as their spatial and temporal control of luminance, high controllability, and a wide detection range. This review focuses on the recent strategic and technological advances in ECL-based biomarker detection systems. We introduce several sensing systems for medical applications that are classified according to the reactions that drive ECL signal emissions. We also provide recent examples of sensing strategies and technologies based on factors that enhance sensitivity and multiplexing abilities as well as simplify sensing procedures. This review also discusses the potential strategies and technologies for the development of ECL systems with an enhanced detection ability.

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Co‐Quenching Effect between Lanthanum Metal–Organic Frameworks Luminophore and Crystal Violet for Enhanced Electrochemiluminescence Gene Detection

Cited by 24 publications

References 60 publications

Reticular Electrochemiluminescence Nanoemitters: Structural Design and Enhancement Mechanism

Reticular Electrochemiluminescence Nanoemitters: Structural Design and Enhancement Mechanism

Perspectives of metal-organic framework nanosystem to overcome tumor drug resistance

Electrochemiluminescence Systems for the Detection of Biomarkers: Strategical and Technological Advances

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