Co-relating HbA1c and serum IgA in diabetic and non-diabetic patients with and without periodontitis

Abstract

Objective: Diabetics are more susceptible to the infections than the non-diabetics (healthy) one, suggesting that the immunologic capability may be unbalanced in diabetics. Periodontitis is associated with alterations in immune responses in both diabetic and non-diabetic subjects. Till date various attempts has been taken to monitor host immunological response of diabetic individuals. Therefore the need to study the local immune response in infl amed gingival showing Periodontitis is apparent. Since till date there are no well documented and signifi cant baseline studies are available on the functional capacities of the lymphoid cells present in gingiva of the periodontitis patients, a study to check the level of immunoglobulin was investigated. Methodology: A study was carried out where HbA1c, Random Blood Sugar and Serum IgA level were assessed in 60 patients from the OPD of RCDSR. 15 patients each belonging to the four groups diabetic with periodontitis, diabetic without periodontitis, nondiabetic with periodontitis and non-diabetic without periodontitis (control) were analysed for the quantitative estimation of Serum Immunoglobulin A by Turbidometric Immunoassay and HbA1c was done by using Nyco card Reader. Result: The data thus obtained were compared with the level of immunoglobulin found in clinically healthy gingival of the control group. The levels of IgA were found to be high in group 'A' (Diabetic patients suffering from Periodontitis) group 'B' (Diabetic patients not suffering from Periodontitis) and group 'C' (Non-diabetic patients suffering from Periodontitis) but the values are not differing statistically from each other. But, the values of all these groups are statistically highly differed from the value obtained against the normal/healthy controlled group 'D'. Conclusion: In our study it can be concluded that there was positive co-relation between the two parameters: elevated HbA1c and Immunoglobulin level with periodontitis. This co-relates to the possibility of an underlying immuno-infl ammatory abnormality to be the cause for the elevated level of immunoglobulin in our patients with elevated sugar level.

Salvadora persica leaf aqueous extract attenuates hyperglycemia and hyperlipidemia in alloxan induced diabetic male rats

“…In addition, the immunoglobulin's (IgG, IgA and IgM) levels were increased by diabetes [38,41] and they were decreased with the administration of the aqueous extract of S. persica to the alloxan induced diabetic rats in G3 and G4 for 4 weeks. This result is consistent with recent studies by Deepti et al [42] who reported that there was a positive correlation between the two parameters elevated HbA1c and Immunoglobulin level. Immunoglobulin levels in diabetes revealed significant increase of IgG, IgA and IgM in patients compared to healthy controls [9,43].…”