Co-Relation Between First Trimester Uric Acid Concentration and Development of Gestational Diabetes Mellitus

Abstract

Gestational diabetes mellitus (GDM) is defined by the World Health Organization (WHO) as a carbohydrate intolerance resulting in hyperglycemia of varying severity with onset or first recognition during pregnancy 1 (WHO, 1999). The present study was done to find out the correlation between 1 st trimester uric acid concentration and the development of GDM. GDM was diagnosed based on the OGCT and GTT test. Study was done in a total of 1002 patients. Uric acid concentration of >3.6mg/dl was considered abnormal (AJOG, vol201, oct2009) 2 .749 patients had normal uric acid and 253 patients had abnormal uric acid. A total of 65 patients were diagnosed to have GDM (6.48%).

Elevated 1st trimester serum uric acid - a risk for gestational diabetes mellitus among South-Indians: a prospective observational, longitudinal study

“…In the present study 58.9% are primigravida and 41.1% are multigravida, from which 22% of primigravida and 24% of multigravidas developed GDM; similarly, Rajakumar et al study included 63.5% Primigravida and 36.4% multigravida and there was no difference in SUA at 1 st trimester in relation to parity. 21 In contrast Nagalakshmi et al has reported a higher risk of GDM among multigravida. In the present study 36% of the women had risk factors for development of GDM like elderly primigravida, PCOD, obesity, hypothyroidism, and diabetes mellitus among 1 st degree relatives and 31% of them developed GDM.…”

“…Similar finding of elevated 1 st trimester SUA levels with different cut-off values by multiple authors are compared in Table 3. 9,11,13,[21][22][23][24][25][26][27][28] Mean SUA in No GDM group in the present study is 3.1±0.7mg/dl and in GDM group it is 3.5±0.9mg/dl and when this cut-off point (≥3.5mg/dl) is employed, it is also found to be statistically significant in predicting at risk women for development of GDM with 'p' values of 0.023 when equal variances assumed and 0.038 when equal variances are not assumed. From this and study of other researchers it appears that, it may not be helpful to employ a cut-off value for SUA of <3.2mg/dl in 1 st trimester to determine women at risk for development of GDM.…”

Maternal uric acid levels and risk of gestational diabetes mellitus: A systematic review and dose–response meta‐analysis of cohort studies including 105,380 participants

“…Furthermore, 19 studies were excluded after the full-text screening. Finally, 23 studies were eligible for inclusion in the present study [18][19][20][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] . Table 1 summarizes the characteristics of the included studies.…”

“…The maternal blood uric acid concentration during pregnancy was measured in 21 of 23 studies at or before the 20th week of gestation [18][19][20]25,[27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] , and the remaining studies measured it after the 20th week of gestation 26,44 . The maternal blood uric acid concentration during pregnancy was measured using calorimetric assays 18,20,25,27,28,[30][31][32][33][36][37][38][39]41 or a spectrometric method 29 , whereas eight out of 23 included studies did not provide data regarding the method of maternal blood uric acid measurement 19,26,34,35,40,[42][43][44] . Among the 23 included studies, five studies collected blood samples after 8-12 h of fasting for the measurement of maternal uric acid…”

“…The maternal blood uric acid concentration during pregnancy was measured using calorimetric assays 18,20,25,27,28,[30][31][32][33][36][37][38][39]41 or a spectrometric method 29 , whereas eight out of 23 included studies did not provide data regarding the method of maternal blood uric acid measurement 19,26,34,35,40,[42][43][44] . Among the 23 included studies, five studies collected blood samples after 8-12 h of fasting for the measurement of maternal uric acid 19,27,33,34,39 ; the remaining studies did not report the method by which blood samples were collected 18,20,25,26,[28][29][30][31][32][35][36][37][38][40][41][42][43][44] . Among the studies included in this systematic review, 13 studies were carried out on participants who were primiparous or multiparous…”