Co-selection of antibiotic and heavy metal resistance in freshwater bacteria

Cesare, Andrea Di; Eckert, Ester M.; Corno, Gianluca

doi:10.4081/jlimnol.2016.1198

Cited by 102 publications

(59 citation statements)

References 72 publications

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“…The mechanisms employed by bacteria to protect against Zn include reducing absorption, increasing efficiency of efflux, transformation of toxic forms to low toxicity and internal isolation, some of which might cause resistance to antibiotics. There is compelling support for the notion that exposure to heavy metals can act as an indirect selective pressure for maintaining antibiotic resistance (Cesare, Eckert, & Corno, ; Hu, Wang, Li, Li, et al., ; Medardus et al., ). The co‐selection of heavy metal and ARGs in various ecological conditions, such as waters, sediments and soils, which increase the complexity of the ecological role of ARGs, and debases the effectiveness of prevention and control actions, has also been postulated to be an important element for the spread and persistence of ARGs (Hu, Wang, Li, Li, et al., ; Hu, Wang, Li, Shi, et al., ; Peltier et al., ; Seiler & Berendonk, ).…”

Section: Discussionmentioning

confidence: 99%

Co‐selection for antibiotic resistance genes is induced in a soil amended with zinc

Yang

Yanpeng

Wang

et al. 2019

Soil Use and Management

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The likelihood of co‐selection for antibiotic resistance induced by heavy metals is a potential threat to human health, however, direct evidence of heavy metal‐induced co‐selection of antibiotic resistance is lacking in soil. By using a metagenomic sequencing approach, zinc (Zn) driven co‐selection of antibiotic resistance genes (ARGs) in soil was investigated through a microcosm experiment where Zn salts were added at different levels. The results showed that the abundance and diversity of ARGs had a tendency to increase along the gradient of increasing Zn contents, with the maximum values recorded in the soil amended with 800 mg Zn kg−1. The abundance of mobile genetic elements (MGEs) such as integrons and insertion sequences was significantly increased by Zn exposure. Network analysis demonstrated significant associations between ARGs and MGEs, suggesting that Zn treatment might enhance the potential for horizontal transfer of ARGs. Furthermore, structural equation models revealed that the types of ARGs were primarily driven by variations in bacterial compositions and Zn exposure, followed by integrons. Thus, these results indicate that added Zn salts considerably changed the diversity, abundance and mobility potential of antibiotic resistance, and imply that application of amendments containing high levels of Zn to soil could be causing the emergence and release of ARGs to the environment, and should be carefully monitored.

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Section: Discussionmentioning

confidence: 99%

Co‐selection for antibiotic resistance genes is induced in a soil amended with zinc

Yang

Yanpeng

Wang

et al. 2019

Soil Use and Management

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“…Selection for a particular plasmid or mobile element can then be mediated by selection for any one of the resistance determinants it encodes, while the remaining genes are coselected by simple linkage. This has been demonstrated for pollution with disinfectants, and it has been commonly reported that exposure to metals coselects for antibiotic resistance and vice versa . The selective agents do not have to be present at inhibitory concentrations for the effect to be observed .…”

Section: Coselection and Emergent Propertiesmentioning

confidence: 92%

Lateral gene transfer, bacterial genome evolution, and the Anthropocene

Gillings

2016

Annals of the New York Academy of Sciences

120

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Lateral gene transfer (LGT) has significantly influenced bacterial evolution since the origins of life. It helped bacteria generate flexible, mosaic genomes and enables individual cells to rapidly acquire adaptive phenotypes. In turn, this allowed bacteria to mount strong defenses against human attempts to control their growth. The widespread dissemination of genes conferring resistance to antimicrobial agents has precipitated a crisis for modern medicine. Our actions can promote increased rates of LGT and also provide selective forces to fix such events in bacterial populations. For instance, the use of selective agents induces the bacterial SOS response, which stimulates LGT. We create hotspots for lateral transfer, such as wastewater systems, hospitals, and animal production facilities. Conduits of gene transfer between humans and animals ensure rapid dissemination of recent transfer events, as does modern transport and globalization. As resistance to antibacterial compounds becomes universal, there is likely to be increasing selection pressure for phenotypes with adverse consequences for human welfare, such as enhanced virulence, pathogenicity, and transmission. Improved understanding of the ecology of LGT could help us devise strategies to control this fundamental evolutionary process.

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“…This generates opportunities for coselection and fixation of chemical (toxic metals) and resistance determinants in species, and within individual DNA molecules (Johnson et al., ; Zhou et al., ). An investigation by Di Cesare, Eckert, and Corno (), Di Cesare, Eckert, D'Urso et al. () on three WWTPs revealed that heavy metal resistance genes may play a crucial role in the spreading of ARGs via mobile genetic elements.…”

Section: Tracking the Movement Of Resistance Genes In Earth's Criticamentioning

confidence: 99%

Human dissemination of genes and microorganisms in Earth's Critical Zone

Zhu

Gillings

Simonet

et al. 2017

Global Change Biology

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Earth's Critical Zone sustains terrestrial life and consists of the thin planetary surface layer between unaltered rock and the atmospheric boundary. Within this zone, flows of energy and materials are mediated by physical processes and by the actions of diverse organisms. Human activities significantly influence these physical and biological processes, affecting the atmosphere, shallow lithosphere, hydrosphere, and biosphere. The role of organisms includes an additional class of biogeochemical cycling, this being the flow and transformation of genetic information. This is particularly the case for the microorganisms that govern carbon and nitrogen cycling. These biological processes are mediated by the expression of functional genes and their translation into enzymes that catalyze geochemical reactions. Understanding human effects on microbial activity, fitness and distribution is an important component of Critical Zone science, but is highly challenging to investigate across the enormous physical scales of impact ranging from individual organisms to the planet. One arena where this might be tractable is by studying the dynamics and dissemination of genes for antibiotic resistance and the organisms that carry such genes. Here we explore the transport and transformation of microbial genes and cells through Earth's Critical Zone. We do so by examining the origins and rise of antibiotic resistance genes, their subsequent dissemination, and the ongoing colonization of diverse ecosystems by resistant organisms.

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Co-selection of antibiotic and heavy metal resistance in freshwater bacteria

Abstract: Antibiotic

Cited by 102 publications

References 72 publications

Co‐selection for antibiotic resistance genes is induced in a soil amended with zinc

Co‐selection for antibiotic resistance genes is induced in a soil amended with zinc

Lateral gene transfer, bacterial genome evolution, and the Anthropocene

Human dissemination of genes and microorganisms in Earth's Critical Zone

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