A holistic vehicle simulation capability is necessary for front-loading component, subsystem, and controller design, for the early detection of component and subsystem design flaws, as well as for the model-based calibration of powertrain control modules. The current document explores the concept of holistic vehicle simulation by means of reviewing the current trends automotive system design and available solutions in terms of model interfaces and neutral modelling environments. The review is followed by the presentation of a Simulink-based Multi-disciplinary Modelling Environment (MME) developed by the authors to accommodate simulation work across the vehicle development cycle.