Co-stabilization of pioglitazone HCL nanoparticles prepared by planetary ball milling: <i>in-vitro</i> and <i>in-vivo</i> evaluation

Alshora, Doaa H.; Alsaif, Shaikha; Ibrahim, Mohamed A.; Ezzeldin, Essam; Almeanazel, Osaid T.; Ela, Amal El Sayeh Abou El; Ashri, Lubna Y.

doi:10.1080/10837450.2020.1744163

Cited by 12 publications

(8 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the PDI values were 0.36–0.41 while the zeta potential values were −17.4 mV, −19.4 mV, and −18.3 mV, respectively. Alshora et al ( Alshora et al, 2020 ) showed PL F-127 concentration showed a slight effect on the size of pioglitazone HCl nanoparticles prepared by wet milling decreased significantly.…”

Section: Resultsmentioning

confidence: 99%

Fluconazole nanoparticles prepared by antisolvent precipitation technique: Physicochemical, in vitro, ex vivo and in vivo ocular evaluation

Ela

Ibrahim

Alqahtani

et al. 2021

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

The goal of this research was to prepare and characterize nanonized particles of the antifungal drug, fluconazole (FLZ) using antisolvent precipitation nanonization technique to improve its ocular permeation. The impact of various concentrations of different stabilizers, namely Pluronic F-127 (PL F 127), Kollicoat IR (KL), hydroxypropyl methylcellulose E3 (HPMC), xanthan gum (XG), polyvinyl pyrrolidone K30 (PVP), and sodium lauryl sulfate (SLS) upon the resulting nanoparticles was investigated. Additionally, the ex vivo release of the FLZ nanonized particles from ophthalmic gel bases was studied by using goat cornea, and the ocular pharmacokinetics of appropriate ophthalmic gel base containing optimized drug nanoparticle formula compared to the untreated drug were studied in rabbits. FLZ nanoparticles were successfully prepared with different concentrations of stabilizers. However, the effects of these stabilizers on nanoparticle size and zeta potential values varied according to the concentration and type of stabilizer used. Based on differential scanning calorimetry, the drug was in its amorphous state in the tested nanoparticle formulations. The results of ex vivo ocular diffusion of the FLZ nanoparticle gel formulations revealed an improvement compared to that with the FLZ untreated gel. Nanoparticle formula (F3) prepared by using 5% PL F127 showed small particle size (352 ± 6.1 nm) with zeta potential value of −18.3 mV with highest ex vivo release rate from goat cornea (100% after 6 h). Moreover, the AUC 0-8h from ocular application of FLZ from sodium alginate gel containing nanoparticle formula F3 was 1.4-fold higher than that after its administration in the untreated formula. Based on our findings, the ophthalmic gel formulations containing FLZ nanoparticles enhanced drug corneal permeation and improved the ocular pharmacokinetic parameters.

show abstract

Section: Resultsmentioning

confidence: 99%

Fluconazole nanoparticles prepared by antisolvent precipitation technique: Physicochemical, in vitro, ex vivo and in vivo ocular evaluation

Ela

Ibrahim

Alqahtani

et al. 2021

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

show abstract

“…However, increasing the concentration of PLF from 0.5 % to 1 % did not produce the same results. Alshora et al ( Alshora et al, 2020 ) reported that PLF127 concentration showed a slight effect on the size of pioglitazone HCl nanoparticles prepared via wet milling. Polymeric stabilizers such as PL, KL, HPLC, and XG increase nanosuspension stability via adsorption to the surface of the nanoparticles, thereby producing steric repulsion amongst particles and increasing nanosuspensions viscosity to prevent aggregation processes ( Xue and Sethi, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Formulation and evaluation of Fluconazole Nanosuspensions: In vitro characterization and transcorneal permeability studies

Aldosari,

Ibrahim,

Alqahtani

et al. 2024

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

“…The nanoformulation of the poorly water-soluble drug Ketoprofen was developed using mannitol medium and a Hoover automatic miller [26]. Nanoparticles of the oral antidiabetic agent Pioglitazone were produced [27] through the wet milling technique in a planetary ball mill, resulting in particle sizes ranging from 600 to 2000 nm depending on the experimental conditions. The dissolution rate of the nanoformulation increased by 1.5 to 10 times.…”

Section: Millingmentioning

confidence: 99%

Pharmaceutical Nanoparticles Formation and Their Physico-Chemical and Biomedical Properties

Shabatina,

Gromova,

Vernaya

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

The use of medicinal substances in nanosized forms (nanoforms, nanoparticles) allows the therapeutic effectiveness of pharmaceutical preparations to be increased due to several factors: (1) the high specific surface area of nanomaterials, and (2) the high concentration of surface-active centers interacting with biological objects. In the case of drug nanoforms, even low concentrations of a bioactive substance can have a significant therapeutic effect on living organisms. These effects allow pharmacists to use lower doses of active components, consequently lowering the toxic side effects of pharmaceutical nanoform preparations. It is known that many drug substances that are currently in development are poorly soluble in water, so they have insufficient bioavailability. Converting them into nanoforms will increase their rate of dissolution, and the increased saturation solubility of drug nanocrystals also makes a significant contribution to their high therapeutic efficiency. Some physical and chemical methods can contribute to the formation of both pure drug nanoparticles and their ligand or of polymer-covered nanoforms, which are characterized by higher stability. This review describes the most commonly used methods for the preparation of nanoforms (nanoparticles) of different medicinal substances, paying close attention to modern supercritical and cryogenic technologies and the advantages and disadvantages of the described methods and techniques; moreover, the improvements in the physico-chemical and biomedical properties of the obtained medicinal nanoforms are also discussed.

show abstract

Co-stabilization of pioglitazone HCL nanoparticles prepared by planetary ball milling: in-vitro and in-vivo evaluation

Cited by 12 publications

References 29 publications

Fluconazole nanoparticles prepared by antisolvent precipitation technique: Physicochemical, in vitro, ex vivo and in vivo ocular evaluation

Fluconazole nanoparticles prepared by antisolvent precipitation technique: Physicochemical, in vitro, ex vivo and in vivo ocular evaluation

Formulation and evaluation of Fluconazole Nanosuspensions: In vitro characterization and transcorneal permeability studies

Pharmaceutical Nanoparticles Formation and Their Physico-Chemical and Biomedical Properties

Contact Info

Product

Resources

About