CO₂ Delivery To Accelerate Incisional Wound Healing Following Single Irradiation of Near-Infrared Lamp on the Coordinated Colloids

Abstract

Traditional wound care methods include wound infection control, adequate nutritional supplements, education of changing position every 2-3 h to avoid tissue hypoxia, vacuum assistant closure, debridement, skin graft, and tissue flap. Electric current stimulation, ultrasound, laser, and hydrotherapy have emerged as adjuvant therapies. However, most, if not all, of these therapies are expensive, and the treatment results are variable. The development of the active methods to improve wound healing is mandatory. CO administration has been known to improve microcirculation and local oxygen supply that are beneficial to wound healing. Here, the metal ion-ligand coordination nanoarchitecture was designed to reveal NIR light-induced CO generation for wound healing. The administration simply topically dropped the colloidal solution on the incisional wound, followed by exposure of near-infrared (NIR) lamp to yield CO, resulting in the observation of the accelerated wound healing.

Infrared Skin‐Like Active Stretchable Electronics Based on Organic–Inorganic Composite Structures for Promotion of Cutaneous Wound Healing

“…The NIR light with 700–1000 nm wavelength has been used in clinical treatment for promoting wound healing and many previous studies showed that the NIR light can accelerate wound healing through inflammation inhibition, angiogenesis enhancement, and collagen deposition . Here, we aim to demonstrate whether the ISASE equipped with NIR LEDs could accelerate skin wound healing of rats.…”

“…In the course of irradiation, the treated rats showed less weeping and suppurating, indicating the inhibited inflammatory response over the wound bed. To identify the putative appearance, hematoxylin and eosin (H&E) stain was performed to measure the inflammation cells in skin tissue over wounds . On day 3, the regenerated tissue was abnormal, with much more granulation tissue, in the nonirradiated control group (Figure d‐i) compared with the irradiated rat (Figure d‐ii).…”

“…Collagen deposition is thus the key for repair and regeneration of the skin . Therefore, Masson's trichrome stain was performed to explore whether ISASE irradiation can promote collagen deposition . The results showed that collagen particles were orderly restructured on day 3 in treated rats (Figure e‐ii), but it was substituted with edematous fluid in control rats (Figure e‐i).…”

Efficient Wound Healing Using a Synthetic Nanofibrous Bilayer Skin Substitute in Murine Model

“…21 The promising physical, mechanical, and in vitro biological properties of the bilayer scaffold 21 encouraged us to perform the present study and investigate the niche response in murine skin wound model. There are different types of animal wound models, including incisional, 30 excisional, 31 burn, 32 and GT models. 33 Among which, the excisional wound model allows for the broadest assessment of wound healing mechanisms because the healing initiates from the wound margins.…”

Bioinorganics and Wound Healing

“…Carbonate‐enriched hot water has been demonstrated to significantly improve wound closure; however, the influence of the other ions potentially beneficial to the healing (e.g.,: calcium) was not studied. Local delivery of carbon dioxide releasing microparticles has been shown to improve blood flow, wound closure, as well as microvessel formation and collagen deposition …”