CO2 laser of oral dysplasia: clinicopathological features of recurrence and malignant transformation

Jerjes, Waseem; Upile, Tahwinder; Hamdoon, Zaid; Al-Khawalde, Mohammed; Morcos, Mira; Mosse, Charles A.; Hopper, Colin

doi:10.1007/s10103-011-0916-z

Cited by 46 publications

(41 citation statements)

References 15 publications

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“…Recurrence and malignancy rates for our cohort (33.8% and 15.4%, respectively) were similar to rates (7.7% and 40% for recurrences and 0.83% and 14% for malignancies) reported for other studies (Chiesa et al, 1993;Schoelch et al, 1999;Thomson, 2002;Thomson and Wylie, 2002;Chandu and Smith, 2005;Van der Hem et al, 2005;Yang et al, 2011;Deppe et al, 2012;Jerjes et al, 2012;Brouns et al, 2013aBrouns et al, , 2014. We would recommend close lifelong follow-up with photographs, along with new biopsies when changes are detected.…”

Section: Resultssupporting

confidence: 88%

“…No randomized trials are reported in the literature that compare surgery with CO 2 laser in terms of local recurrence and malignant transformation (Brouns et al, 2013a). The recurrence and malignant transformation rates for our sample were 33.8% and 15.4%, respectively, comparable with those found in literature (7.7%e40% for recurrences and 0.83%e14% for malignant transformation; Table 4) (Chiesa et al, 1993;Schoelch et al, 1999;Thomson, 2002;Thomson and Wylie, 2002;Chandu and Smith, 2005;Van der Hem et al, 2005;Yang et al, 2011;Deppe et al, 2012;Jerjes et al, 2012;Brouns et al, 2013aBrouns et al, , 2014. It is currently unknown whether resection margin width is a factor in recurrence, and no molecular marker currently exists that determines this risk.…”

Section: Discussionsupporting

confidence: 84%

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The treatment of oral leukoplakia with the CO2 laser: A retrospective study of 65 patients

Mogedas-Vegara

Hueto-Madrid

Küstner³

et al. 2015

Journal of Cranio-Maxillofacial Surgery

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a b s t r a c tThe use of CO 2 laser has become a routine procedure for the treatment of oral leukoplakia. In this retrospective study, we evaluated 65 patients with oral leukoplakia treated with CO 2 laser vaporization. The main location was the tongue (n ¼ 21/65, 32.3%). The initial biopsy showed mild/moderate dysplasia in almost half the patients (n ¼ 29, 44.6%) and hyperplasia without dysplasia in around a third of the patients (n ¼ 21, 32.3%). The recurrence and malignant transformation rates were 33.8% (n ¼ 22) and 15.4% (n ¼ 10), respectively. The follow-up mean (standard deviation) was 15.0 (10.6) months. The procedure-related complications rate was 7.7% (n ¼ 5). The KaplaneMeier curves for time to recurrence showed differences only for gingiva lesions compared to tongue lesions (log rank, p ¼ 0.032). Malignant leukoplakia transformation is independent of treatment, although it seems advisable to treat leukoplakia with or without dysplasia.

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Section: Resultssupporting

confidence: 88%

Section: Discussionsupporting

confidence: 84%

The treatment of oral leukoplakia with the CO2 laser: A retrospective study of 65 patients

Mogedas-Vegara

Hueto-Madrid

Küstner³

et al. 2015

Journal of Cranio-Maxillofacial Surgery

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“…Dysplastic lesions undergo transformation into malignancy over time. It has been reported that malignant transformation was observed in 10.4%, and the rate of first recurrence after laser surgery was approximately 19.5% [35]. The rate of recurrence had significant association with the severity of epithelial dysplasia [35].…”

Section: Epithelial Dysplasiamentioning

confidence: 95%

“…It has been reported that malignant transformation was observed in 10.4%, and the rate of first recurrence after laser surgery was approximately 19.5% [35]. The rate of recurrence had significant association with the severity of epithelial dysplasia [35]. Recurrence and malignant transformation was mainly identified in erythroplakias and non-homogenous leukoplakias [35].…”

Section: Epithelial Dysplasiamentioning

confidence: 97%

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Preneoplasia and carcinogenesis of the oral cavity

Watanabe¹,

Ohkubo²,

Shimizu³

et al. 2015

Oncol Discov

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Oral cancer, ranking sixth in the cancer incidence worldwide, is one of the most common neoplasms. Preneoplastic or premalignant (precancerous) lesions are lesions that can potentially transform into malignancy in a variety of tissues, including the oral cavity. Such oral lesions may be caused by tobacco use, exposure to the human papillomavirus and chewing of the betel nut. These substances contain carcinogens and/or tumor promoters. The mucosa of the oral cavity is covered with squamous epithelium and is relatively resistant to injury. However, exposure to these substances can cause the mucosa to undergo changes. The changes are usually initiated by a leukoplakic patch. While some leukoplakic patches recover and resolve, others progress to squamous cell carcinoma with or without invasion. Other premalignant lesions include oral submucous fibrosis, which is a potentially malignant condition caused by the abuse of the betel nut. Understanding the histology, premalignant states and molecular mechanisms of oral carcinogenesis may facilitate the development of novel strategies for the prevention and treatment of oral cancer. In addition, early detection is of critical importance to improve the survival rates of patients with oral cancer. In this review, we will summarize these aspects of oral cancer development, beginning from the histology of the oral cavity.

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Investigation of the differentiation ofex vivonerve and fat tissues using laser-induced breakdown spectroscopy (LIBS): Prospects for tissue-specific laser surgery

et al. 2016

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In the present study, the elemental compositions of fat and nerve tissue during their plasma mediated laser ablation are studied in the context of tissue differentiation for laser surgery applications by using Laser‐Induced Breakdown Spectroscopy (LIBS). Tissue samples of porcine fat and nerve were prepared as ex vivo experimental objects. Plasma mediated laser ablation is performed using an Nd : YAG laser in open air and under normal stray light conditions. The performed measurements suggest that the two tissue types show a high similarity in terms of qualitative elemental composition while at the same time revealing a distinct difference in the concentration of the constituent elements. Different analysis approaches are evaluated and discussed to optimize the tissue‐differentiation performance of the LIBS approach.

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CO2 laser of oral dysplasia: clinicopathological features of recurrence and malignant transformation

Cited by 46 publications

References 15 publications

The treatment of oral leukoplakia with the CO2 laser: A retrospective study of 65 patients

The treatment of oral leukoplakia with the CO2 laser: A retrospective study of 65 patients

Preneoplasia and carcinogenesis of the oral cavity

Investigation of the differentiation ofex vivonerve and fat tissues using laser-induced breakdown spectroscopy (LIBS): Prospects for tissue-specific laser surgery

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