CO2 pneumoperitoneum increases systemic but not local tumor spread after intraperitoneal murine neuroblastoma spillage in mice

Abstract

CO(2) pneumoperitoneum increased intrahepatic metastasis, but not local peritoneal carcinosis in a murine neuroblastoma model. This suggests that laparoscopy could promote systemic dissemination of intraperitoneally spilled tumor cells when no chemotherapy is applied. It remains to be determined whether this is due to local immune suppression or direct modulation of tumor cell behavior.

Carbon dioxide does not affect the methylation status of prognostic important oncogenes Rassf1A and DCR2 in neuroblastoma cells

“…In case of neuroblastoma, the most frequent solid childhood tumor, data are inconsistent. While series with small, localized and well-encapsulated tumors showed a good feasibility of laparoscopic resection [6], higher rates of metastases were found after minimally invasive neuroblastoma resection in experimental settings [4,5].…”

“…Many cases have been reported in which different types of malignant tumors have metastasized after laparoscopy [1][2][3][4][5]. The pneumoperitoneum, usually with CO 2 , is a crucial feature of laparoscopy.…”

“…Reports on pediatric solid tumors are contradictory. While murine neuroblastoma models showed a significant increase of liver and port-site metastases after CO 2 pneumoperinoneum within laparoscopic tumor resection [4,5], these results were not found clinically [6].…”

Use of laparoscopic surgical resection for pediatric malignant solid tumors: a case series

“…Most reports concluded that laparoscopic resection was acceptable in terms of feasibility and safety. Although one case of port-site metastasis after biopsy of a posttransplant Burkitt lymphoma in a child was recently reported [16], there have been no reports about port-site metastasis after abdominal minimally invasive resection procedures for pediatric malignancies [17]. No reports have provided long-term oncologic results or large-scale comparative studies with conventional operation cases.…”

Minimally Invasive Surgery for Pediatric Tumors – Current State of the Art

“…This especially concerns the use of carbon dioxide (35, 36). However, after being used for a relevant time with respective follow-up, clinical experiences with laparoscopy for pediatric abdominal malignancies seem to indicate that there are no relevant differences in outcome compared to open surgical procedures.…”